[Lowering of the activity of hepatic benzopyrene-hydroxylase in vivo after carbon monoxide inhalation].
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Biomedical subjects
Publications and source records attributed to D Rondia.
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Extracts of atmospheric suspended matter showed a direct mutagenic effect in the Ames test. This effect was increased by metabolic activation. These extracts were separated into an aliphatic, an aromatic and a polar fraction. The aliphatic fraction had no effect, with or without activation; the aromatic fraction showed the greatest mutagenicity with and without activation; the polar fraction was also mutagenic, but its metabolic activation did not enhance the effect. The active compounds in this last fraction could be represented in a significant part by oxygenated derivatives of polycyclic aromatic hydrocarbons.
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Blood lead was measured in two adult male populations who were submitted to different environmental lead exposures. Their differential variations in mean blood lead vs. age result from the difference between the external lead concentrations. It is inferred that a homeostasis phenomena plays a significant role and that the blood compartment is unable to adapt to some extent to a high environmental lead exposure.