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Biomedical subjects

D Ritchie

Publications and source records attributed to D Ritchie.

28 records · Page 2Linked to original sources
PubMed1988

Evaluation of the anaphylactoid activity of a new LHRH antagonist.

ORF 23541 [N-Ac-D-Nal(2)1,D-pCl-Phe2,D-Pal(3)3,Ser4,Nic-Lys5,D-Nic-Lys 6, Leu7, I-Lys8, Pro9,D-Ala10NH2; "Nal-Lys antagonist"] was identified as a potent LHRH antagonist without significant anaphylactoid activity. It blocked ovulation in proestrus rats when administered subcutaneously with an ED50 of 5.8 micrograms/kg. Much higher doses of ORF 23541 than of other antagonists were required to induce a cutaneous anaphylactoid-like reaction. Intradermal administration of ORF 23541 caused an 8.75 x 8.75 mm wheal response with estimated doses of 10.9 and 13.7 micrograms in rats and guinea pigs, respectively. These doses were at least 10 times greater than that required of other LHRH antagonists for the same response. ORF 23541 also did not alter pulmonary function in guinea pigs or dogs when administered intravenously at doses up to 10 mg. These results indicate that ORF 23541 represents a new generation of LHRH antagonists with an improved safety margin.

Anaphylaxis↗
PubMed1979

Dose of terbutaline respirator solution in children with asthma.

Twenty children, aged 8 to 17 years, with bronchial asthma were each given 0.02ml/kg, 0.03ml/kg and 0.04ml/kg terbutaline respirator solution (10mg/ml), one dose at a time on three separate occasions. Terbutaline by nebuliser produced a bronchodilator response within five minutes which reached near peak levels by 15 minutes. There was a wide variation in response. A dose of 0.02ml/kg produce a mean increase in FEV1 of 55 percent and an increase in MMEFR of 121 percent. Doses of 0.03ml/kg and 0.04ml/kg given to the same children resulted in slightly better, but not statistically significant different responses. The effect lasted for four hours, although the MMEFR was falling at this time. The baseline FEV1 did not affect the bronchodilator response. An inhalation of 0.02ml/kg of terbutaline respirator solution (10mg/ml) will produce an adequate bronchodilator response in most children.

Adolescent↗
PubMed1978

Clinical and urodynamic features of failed incontinence surgery in the female.

Sixty women with urinary incontinence were treated by the Burch colposuspension operation and bladder neck plication. The pre- and postoperative clinical and urodynamic features of the 15 patients with recurrent incontinence were compared and contrasted with 45 women who were cured. Factors which were associated with failed surgery included increaseing age, previous continence surgery, the presence of detrusor instability, and a postoperative rise of intrinsic bladder pressure either on filling of standing up.

Adult↗
PubMed1976

The colposuspension operation for urinary incontinence.

Forty-two patients with urinary incontinence and related symptoms were treated by colposuspension. Two patients were lost to follow-up and the results of surgery in the remaining 40 patients are presented and discussed. The place of vaginal surgery in women with urinary symptoms is also discussed.

Adult↗