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Biomedical subjects

D Ricken

Publications and source records attributed to D Ricken.

At least 37 records · Page 2Linked to original sources
PubMed1989

[A transdermal intermittent-release nitroglycerin system. Hemodynamic studies after acute and subchronic use].

The efficacy of a transdermal intermittent-release nitroglycerin system was investigated in a randomized double-blind trial on 24 patients (18 males and six females; median age 57.5 years [range 41-68]) with angiographically proven and haemodynamically significant coronary heart disease. Twelve patients had one plaster, containing 10 mg nitroglycerin, daily for eight days, the other twelve also had one plaster, but without drug, daily for eight days. Resting and exercise haemodynamics were measured on the first day, immediately before and two hours after application of the plaster, on the eighth day 24 hours after the last but one plaster application, and two hours after the last plaster. The mean pulmonary artery pressure, two hours after first plaster application, had dropped at rest from 18.6 to 13.3 mm Hg (29%; P less than 0.001) and after exercise from 43.9 to 34 mm Hg (23%; P less than 0.001). After eight days, 24 hours after application of the penultimate plaster, there was no significant haemodynamic change. Renewed plaster application, however, caused significant haemodynamic changes similar to those on the first day of the study. It is concluded from these findings that this intermittent-release system can achieve long-term results without development of tolerance.

Administration, Cutaneous↗
PubMed1989

Left ventricular after load as a result of levocardiography with contrast media of various osmolality.

Contrast media have been successfully used as a diagnostic aid in radiology for decades. It has, however, been necessary to accept certain, in some cases unexplained, undesirable side effects because of their physicochemical properties. The conventional preparations available have for more than 40 years been iodinated salts or acids, whose major disadvantage has been high osmolality. For some years now, a new generation of contrast media has been available. These contrast media exhibit a far lower osmolality due to the lack of ionicity. As a result of the volume load of the left ventricle by levocardiography, there is usually an increase of the left ventricular end-diastolic pressure in the pathologic range over 12 mmHg. We were able to prove this in 120 consecutive patients whom we examined. The pressure increase with the use of nonionic contrast media was considerably lower. The differentiated observation of various risk groups showed no signs of valid predictive parameters.

Cardiac Output↗
PubMed1988

Effect of ageing on the gastro-intestinal transit of a lactulose-supplemented mixed solid-liquid meal in humans.

Gastro-intestinal transit of a mixed solid-liquid meal containing wheat bread, scrambled eggs, coffee labelled with 99mTc, orange juice with lactulose and indigocarmine was evaluated in 21 young control (mean age 33.5 years) and 25 elderly subjects (mean age 81.7 years) without gastrointestinal complaints or severe medical illness. The rate of gastric emptying was determined by an anterior gamma camera technique, mouth-to-caecum transit by the hydrogen breath test and whole-gut transit by the first stool passage of indigocarmine. Gastric emptying was significantly prolonged in older subjects: t1/2 = 136 +/- (SEM) 13 versus 81 +/- 4 min; p less than 0.001. Concerning mouth-to-caecum or whole-gut transit time, significant differences between the two study groups were not detected.

Adult↗
PubMed1987

[Clozapine-induced cholestatic liver lesions. A case study].

During neuroleptic treatment with clozapine, transitory reversible rise in transaminases is not rare, while severe parenchymal damage with icterus has not previously been reported. Such a case is now described: a 54-year-old woman developed clozapine-induced cholestasis with severe liver damage.

Antipsychotic Agents↗
PubMed1987

[Cardiovascular complications of gastroenterologic endoscopy].

Upper gastrointestinal (GI) tract endoscopies are associated with a cardiovascular complication rate of 0.009% to 0.4%, which may be considered rare events. The endoscopy-associated lethality due to cardiovascular accidents ranges from 0.005% to 0.07%. Sinus tachycardia represents the most frequent cardiovascular finding, and vagolytic premedication often plays a causal role. Such accelerated heart rates may predispose to myocardial ischemia due to an augmented cardiac work load. Electrocardiographic alterations of the ST-T segment have been observed in 4% to 46% of upper GI tract endoscopy patients. Severe arrhythmias are rare phenomena. The cardiovascular risk of colonoscopy and laparoscopy appears to be even smaller as compared to gastroscopy. Advanced age, severe coronary heart disease and cor pulmonale may be useful indicants to identify a high risk patient subgroup.

Arrhythmias, Cardiac↗
PubMed1986

[Significance of serum immunoglobulins for the diagnosis of alcohol-induced liver diseases].

Serum immunoglobulins (IgG, IgA, IgM) were prospectively determined in 524 consecutive patients with degenerative liver damage (mainly steatosis), fibrosis, chronic hepatitis, and cirrhosis, proven by biopsy or visually. Concerning alcohol consumption all patients were assigned to two groups according to previously defined criteria; those with regular alcohol abuse (at least 80 g/d) and those without or with irregular alcohol intake. Serum concentrations of all immunoglobulin classes significantly increased with progredient liver parenchymal destruction from steatosis to chronic hepatitis and fibrosis to cirrhosis. Significant differences in immunoglobulins, especially in IgA, between patients with or without alcohol consumption were not observed. These results indicate that serum immunoglobulin concentrations are related to the degree and not to the etiology (alcoholic/non alcoholic) of liver damage.

Biopsy↗
PubMed1985

[Centrolobular liver cell necroses following occupational halothane contact. Association with antibodies to halothane altered liver cell components].

A report is given on a 24 year old nurse, who developed two episodes of fever, chills and malaise with high serum enzyme levels and histologic proof of extensive centrolobular hepatic necrosis in association with vocational halothane exposure in the operating theatre. A cause-effect relationship was suggested by the demonstration of antibodies against halothane-altered hepatocyte membrane components. Also, there was no indication of other known causes of a cytotoxic liver reaction. In certain predisposed individuals, halothane even in subanaesthetic concentrations is apparently able to induce liver cell damage. Only six further reports on such liver injuries in medical personnel could be found in the literature.

Adult↗
PubMed1984

Prajmaliumbitartrate-associated liver damage. Report on seven further cases with follow-up for two to five years.

Seven further cases with n-propyl-ajmaliumbitartrate (NPAB)-associated liver damage observed between 1976 and 1980 in two collaborating institutions are reported. The cause/effect relationship could be classified as probable in three cases and as potential in the remaining four patients. No drug rechallenge was carried out. In the clinical management, definite exclusion of biliary tract obstruction had a clear priority over histologic documentation of the degree of the transient liver damage. Follow-up data after 2 years 8 months to 5 years 9 months by personal reinvestigation of three patients and by questionnaire to family physicians and patients in the remaining four cases gave no clinical or serologic indication of persisting or relapsing liver damage. Liver biopsies were not considered to be warranted in the follow-up of these asymptomatic patients with normal liver function tests.

Adult↗
PubMed1983

[Seasonal increase in gastroduodenal ulcer].

7084 upper gastrointestinal tract endoscopies in the years 1973 to 1981 revealed 1664 duodenal or gastric ulcers. The number of total ulcer observations in relation to specific months differed between 110 in the 9 June periods and 189 in the 9 October months. A convincing peak was not detected. However, the number of ulcers per month or per season was not distributed evenly, as judged by chi-Square analysis. 30% of all ulcer observations occurred in the fall, 24% in the winter, 24% in the spring and 22% in the summer. Our material did not reveal, whether the slight increase in the fall reflected a true rise in the ulcer incidence or whether it had to be attributed to seasonal variations in referrals for endoscopic examinations. Nevertheless the reported data are further evidence for the perennial rather than seasonal nature of gastroduodenal ulcers.

Duodenoscopy↗