Biomedical subjects
D Rennie
Publications and source records attributed to D Rennie.
Disclosure to the reader of institutional review board approval and informed consent.
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The clinical examination. An agenda to make it more rational.
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Charges for obstetric liability insurance and discontinuation of obstetric practice in New York.
BACKGROUND: The study objective was to determine whether New York physicians facing higher charges for obstetric liability insurance coverage are more likely to discontinue obstetric practice than physicians experiencing lower levels of increases in liability insurance charges. METHODS: We performed a physician-level analysis of factors predicting discontinuation of hospital-based obstetric practice by 1989 for physicians active in obstetrics in 1980. We examined both physicians who became completely clinically inactive in New York between 1980 and 1989, and physicians who remained clinically active but restricted their hospital practice to areas other than obstetrics. Multiple logistic regression models were used to analyze predictors of discontinuation of obstetrics, including regional malpractice insurance charges, physician characteristics, and practice characteristics. RESULTS: Although increases in malpractice insurance charges differed considerably among regions within New York State, there was no association between level of increase of charges for liability insurance and discontinuation of obstetric practice. A greater number of years since medical licensure was associated both with complete discontinuation of hospital practice in New York and selective discontinuation of obstetrical practice. Compared with obstetrician-gynecologists, family physicians were less likely to become completely clinically inactive. Among physicians who remained clinically active in hospital care, however, family physicians were less likely than obstetrician-gynecologists to continue to include obstetrics in their practice. CONCLUSIONS: There is no relationship between the level of increase in liability insurance premiums and the likelihood of discontinuing obstetric practice in New York. Discontinuation of obstetric practice appears to mainly reflect trends in the physician's life cycle of practice activity and in the scope of family and general practice.
The living structured auto-obituary.
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Improving the quality of reporting of randomized controlled trials. The CONSORT statement.
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How to report randomized controlled trials. The CONSORT statement.
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Influences on the quality of published drug studies.
To practice evidence-based medicine, physicians need data on the clinical effectiveness, toxicity, convenience, and cost of new drugs compared with available alternatives. We give examples of published drug studies that are defective, sometimes because pharmaceutical industry funding has affected their content and quality. We make recommendations on how to avoid these defects.
The Cochrane Collaboration. Preparing, maintaining, and disseminating systematic reviews of the effects of health care.
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And now, evidence based editing.
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Peer review in Prague. The International Congress on Biomedical Peer Review and Global Communications, 1997.
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The Brown and Williamson documents. Where do we go from here?
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Plungers and polemics. Active compression-decompression CPR and federal policy.
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Reporting randomized controlled trials. An experiment and a call for responses from readers.
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Cost-effectiveness analyses.
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The publication of commercially supported supplements statement.
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The Second International Congress on Peer Review in Biomedical Publication.
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Publication bias and public health policy on environmental tobacco smoke.
OBJECTIVE: To examine the tobacco industry's claim that publication bias against negative studies invalidates the risk assessment of environmental tobacco smoke (ETS) conducted by the US Environmental Protection Agency and other reviews of the health effects of ETS. DESIGN: Determination of the number of published original research articles that tested the hypothesis that ETS exposure is associated with adverse health effects and that reported statistically significant ("positive") or nonsignificant ("negative") results; the number of articles that concluded that ETS is a health risk; and unpublished studies on the effects of ETS on health. PARTICIPANTS: Articles identified by a computerized search of the medical literature supplemented with material obtained from the tobacco industry and hand searching. Articles were classified as peer-reviewed journal articles or articles from sponsored symposia. MAIN OUTCOME MEASURE: The statistical significance of results reported in the article and whether or not the article concluded that ETS exposure is a health risk. RESULTS: More symposium articles than journal articles were reviews (46% vs 6%; P = .0001). More original journal articles than original symposium articles reported the use of statistical tests (96% vs 54%; P = .0001). Of articles with statistical analyses, similar proportions of journal articles and symposium articles reported statistically significant results (57% vs 47%; P = .329). The conclusions of 80% of the original journal articles were positive, compared with 51% of the original symposium articles (P = .006). CONCLUSIONS: There is no publication bias against statistically nonsignificant results on ETS in the peer-reviewed literature. The high proportion of articles in symposia that reach the conclusion that ETS is not harmful primarily results from the inclusion of review articles.