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D Regan

Publications and source records attributed to D Regan.

At least 37 records · Page 2Linked to original sources
PubMed2000

Estimating the time to collision with a rotating nonspherical object.

We measured the precision (i.e. Weber fraction) and the accuracy with which the time to collision (TTC) with a simulated approaching object is estimated. We simulated a rigid spherical object and a rigid nonspherical object (an oblate spheroid whose longer axis was vertical). We used the following viewing conditions: that the available information about TTC was only monocular (M), only binocular (B) and monocular plus binocular (M and B). In addition to the approaching SPHERE condition, we used the following three simulation conditions for the oblate spheroid: (2) a slow rotation through 90 degrees (SIDE-END); (3) a slow rotation through 90 degrees (END-SIDE); (4) several complete rapid rotations (RROT). Weber fractions for discriminating TTC were similar for all 12 combinations of viewing and simulation conditions. When only monocular information was available, perceived TTC was longer in the M/SIDE-END condition than in the M/SPHERE condition, and shorter in the M/END-SIDE condition than in the M/SPHERE condition. As well, observers were strongly influenced by task-irrelevent variables in the M/SIDE-END condition so that they could not properly perform the task. The addition of binocular information considerably improved the accuracy of estimating TTC in simulation conditions SPHERE, END-SIDE and RROT, and allowed reliably accurate estimations to be made in the SIDE-END simulation condition. We suggest that, when binocular information is combined with monocular information about TTC, the two kinds of information are weighted roughly equally when the approaching object is a rigid sphere, but the binocular information is weighted more heavily when the approaching object is nonspherical and rotating.

Adult↗
PubMed2000

Risky driving behavior: a consequence of motion adaptation for visually guided motor action.

The authors examined the effect of adaptation to expansion on overtaking maneuvers in a driving simulator. Following driving on a straight empty road for 5 min, drivers initiated overtaking substantially later (220-510 ms) than comparable maneuvers made following viewing a static scene or following 5 min of curve driving. Following adaptation to contraction (produced by driving backward), observers initiated overtaking significantly sooner. The removal of the road texture significantly reduced the size of the adaptation effect. The authors propose that these changes in overtaking behavior are due to misestimation of the time headway produced by local adaptation of looming detectors that signal motion-in-depth for objects near the focus of expansion. This adaptation effect may increase the risk of rear-end collisions during highway driving.

Adaptation, Psychological↗
PubMed1999

Similarities and differences between the effects of heparin and glypican-1 on the bioactivity of acidic fibroblast growth factor and the keratinocyte growth factor.

The keratinocyte growth factor (KGF or FGF-7) is unique among its family members both in its target cell specificity and its inhibition by the addition of heparin and the native heparan-sulfate proteoglycan (HSPG), glypican-1 in cells expressing endogenous HSPGs. FGF-1, which binds the FGF-7 receptor with a similar affinity as FGF-7, is stimulated by both molecules. In the present study, we investigated the modulation of FGF-7 activities by heparin and glypican-1 in HS-free background utilizing either HS-deficient cells expressing the FGF-7 receptor (designated BaF/KGFR cells) or soluble extracellular domain of the receptor. At physiological concentrations of FGF-7, heparin was required for high affinity receptor binding and for signaling in BaF/KGFR cells. In contrast, binding of FGF-7 to the soluble form of the receptor did not require heparin. However, high concentrations of heparin inhibited the binding of FGF-7 to both the cell surface and the soluble receptor, similar to the reported effect of heparin in cells expressing endogenous HSPGs. The difference in heparin dependence for high affinity interaction between the cell surface and soluble receptor may be due to other molecule(s) present on cell surfaces. Glypican-1 differed from heparin in that it stimulated FGF-1 but not FGF-7 activities in BaF/KGFR cells. Glypican-1 abrogated the stimulatory effect of heparin, and heparin reversed the inhibitory effect of glypican-1, indicating that this HSPG inhibits FGF-7 activities by acting, most likely, as a competitive inhibitor of stimulatory HSPG species for FGF-7. The regulatory effect of glypican-1 is mediated at the level of interaction with the growth factor as glypican-1 did not bind the KGFR. The effect of heparin and glypican-1 on FGF-1 and FGF-7 oligomerization was studied employing high and physiological concentrations of growth factors. We did not find a correlation between the effects of these glycosaminoglycans on FGFs biological activity and oligomerization. Altogether, our findings argue against the heparin-linked dimer presentation model as key in FGFR activation, and support the notion that HSPGs primarily affect high affinity interaction of FGFs with their receptors.

Animals↗
PubMed1999

Evidence for a mechanism sensitive to the speed of cyclopean form.

We measured Weber fractions for discriminating the speed of cyclopean gratings and Weber fractions for discriminating the speed of luminance gratings. Of our 14 observers, five were unable to see the cyclopean grating sufficiently well to discriminate its speed. One observer experienced great difficulty in discriminating the speed of cyclopean gratings, even though her threshold for detecting cyclopean gratings was low, and even though she discriminated the speed of luminance gratings on the basis of the task-relevent variable. But several observers based their speed discriminations on trial-to-trial variations of the task-relevent variable while ignoring associated trial-to-trial variations in all task-irrelevant variables (specifically: displacement; temporal frequency; spatial frequency; and presentation duration). We conclude that the visual systems of these observers contain a specialized neural mechanism for the speed of cyclopean gratings that supports acute discriminations of speed (Weber fractions were as low as 0.05-0.07).

Differential Threshold↗
PubMed1999

Adapting to expansion increases perceived time-to-collision.

We used a tracking method to measure errors in estimating absolute time-to-collision caused by adapting to an expanding target. After adaptation, the estimated time-to-collision was longer than in the baseline condition. This was the case whether estimates were based on binocular information alone or monocular information alone. Estimates of time-to-collision were lengthened by 8-16% when based on binocular information alone, and by 18-25% when based on monocular information alone. These findings are consistent with a previous proposal that changing-size and changing-disparity information converge before the stage at which motion-in-depth signals are generated.

Adaptation, Psychological↗
PubMed1999

Do monocular time-to-collision estimates necessarily involve perceived distance?

Motivated by the debate between indirect and direct theories of perception, a large number of researchers have attempted to determine whether judgments of time to collision are based on the ratio of perceived distance to perceived speed or on the ratio theta/(d theta/dt), i.e. tau. Despite the considerable research effort devoted to this question there seems to be no clear resolution. We used a staircase tracking procedure to estimate errors in estimating time to collision for a simulated approaching object. To investigate the role of perceived distance in the judgment of time to collision, we asked observers to alternate between two viewing distances (100 and 500 cm). For the 500 cm viewing distance, we magnified the visual display by a factor of five so that the retinal images [and the values of theta/(d theta/dt) through time] were identical for the two viewing distances. All visual cues to distance were available. There were no significant differences between estimates of time to collision made at the two viewing distances. We conclude that our observers ignored perceived distance when estimating time to collision and based their responses on theta/(d theta/dt). We concur with recent proposals that, in the future, time-to-collision research should move away from the either/or analysis of different information sources that has dominated previous studies towards investigations of how different information sources are integrated.

Adult↗
PubMed1999

Randomized, double-blind, placebo-controlled trial to evaluate the hematopoietic growth factor PIXY321 after moderate-dose fluorouracil, doxorubicin, and cyclophosphamide in stage II and III breast cancer.

PURPOSE: To measure the effect of PIXY321 (granulocyte-macrophage colony-stimulating factor/interleukin-3 S. cerevisiae fusion protein) on the incidence, duration, and complications of neutropenia and thrombocytopenia after moderate-dose fluorouracil 600 mg/m(2), doxorubicin 60 mg/m(2), and cyclophosphamide 750 mg/m(2) (FAC) chemotherapy in patients with stage II and III breast cancer. PATIENTS AND METHODS: In this multicenter, randomized, double-blind placebo-controlled trial, 71 women were to receive four 21-day cycles of treatment with moderate-dose FAC chemotherapy by short intravenous infusion on day 1, followed by either placebo or PIXY321 (375 microg/m(2) subcutaneously twice a day) on days 3 to 15. All patients were to receive prophylactic oral ciprofloxacin when the absolute neutrophil count was less than 1,000/microL. RESULTS: PIXY321 significantly reduced the incidence and duration of grade 3 and grade 4 neutropenia in cycles 1 and 2 and the duration of grade 3 neutropenia in cycles 1 through 4. In cycles 3 and 4, grade 3 thrombocytopenia was significantly more common with PIXY321 (P <.05). Two patients, both in the PIXY321 group, required platelet transfusions. Fever and hospitalization for intravenous antibiotics were significantly more common in the PIXY321 group during cycle 1 only. More patients in the PIXY321 group achieved hematologic recovery by day 22 in cycles 1 through 3, and time to recovery was significantly shorter with PIXY321 in all cycles. FAC dose intensity was roughly 2% higher in the PIXY321 group (P = NS). Nonhematologic events of any intensity occurring with significantly greater overall frequency in the PIXY321 group included injection-site reactions, fever, chills, abdominal pain, and arthralgia. No patient died on study or within 30 days of her last dose of study drug. CONCLUSION: PIXY321 decreased the incidence and duration of FAC-induced grade 3 and 4 neutropenia in cycles 1 and 2 and significantly shortened the time to hematologic recovery in all cycles. However, it produced more systemic toxicity as well as thrombocytopenia in cycles 3 and 4.

Adenocarcinoma↗
PubMed1999

Motion in depth: adequate and inadequate simulation.

We measured errors in estimating the absolute time to collision with a simulated approaching textured object. The texture elements were circular bright dots. When we matched the rate of angular expansion of the simulated object, the rate of expansion of the texture dots, and the rate of increase of dot separation, so as to accurately simulate an approaching object, errors were small underestimations that were independent of dot size (mean of 3.2%). When dot angular size was held constant during the simulated approach, errors were the same as when the simulation was accurate, provided that dot size was less than 2.2-4.4 min of arc. As dot size was progressively increased, errors changed to overestimations. For the largest dot size used (10.5 min of arc at time t = 0), time to collision was overestimated by up to 21%. A sufficiently large overestimation would mean that measures taken to avoid collision would be too late. We suggest that the relevance to everyday life of data on the perception of motion in depth and self-motion collected using constant-sized dot displays might be questionable if dot size exceeds 2.2-4.4 min of arc.

Adult↗
PubMed1998

Accuracy of estimating time to collision using binocular and monocular information.

We measured both the just-noticeable difference in time to collision (TTC) with an approaching object, and the absolute accuracy in estimating TTC in the following cases: only binocular information available; only monocular information available; both binocular and monocular information available as in the everyday situation. Observers could discriminate trial-to-trial variations in TTC on the basis of binocular information alone: the just-noticeable difference in TTC (5.1-9.8%) was the same for a small (0.03 deg) target and for a large (0.7 deg) target. In line with previous reports, when only monocular information was available, the just-noticeable difference in TTC was 5.8-12% for the large target. However, observers could not reliably discriminate trial-to-trial variations in TTC with the small target when only monocular information was available. When both binocular and monocular information was available, the just-noticeable difference in TTC for the large target was not significantly different from when only binocular or only monocular information was available. Observers could make reliable estimates of absolute TTC using binocular information only. Errors ranged from 2.5 to 10% for the large target, and 2.6 to 3.0% for the small target, all being overestimates. Errors for the small target were the same or lower than errors for the large target. Observers could make reliable estimates of TTC with the large target using monocular information only. Errors ranged from 2.0 to 12%, all being underestimates. Since monocular information did not provide a basis for reliable estimates of absolute TTC with the small target we conclude that, in everyday conditions, accurate estimates of TTC with small targets are based on binocular information when the object is small and is no more than a few metres away. Errors in estimating absolute TTC were lower in the case where both binocular and monocular information were available (as in the everyday situation) than when only binocular information or only monocular information was available. Errors ranged from 1.3 to 2.7%. An error of 1.3% approaches the accuracy required to explain the +/- 2.0-2.5 msec accuracy with which top sports players can estimate the instant of impact between bat and ball.

Depth Perception↗
PubMed1998

Spatial frequency discrimination and detection characteristics for gratings defined by orientation texture.

We describe evidence consistent with the proposal that the visual system contains a parallel array of size-tuned mechanisms sensitive to orientation texture-defined (OTD) form, and propose that the relative activity of these mechanisms determines spatial frequency discrimination threshold for OTD gratings. Using a pattern of short lines we measured spatial frequency discrimination thresholds for OTD gratings and luminance-defined (LD) gratings. For OTD gratings, the orientation of texture lines varied sinusoidally across the bars of the gratings, but line luminance was constant. For LD gratings, line orientation was constant, but line luminance varied sinusoidally across the bars of the grating. When the number of texture lines (i.e. spatial samples) per grating cycle was below about six, spatial sampling strongly affected both the spatial frequency discrimination and grating detection thresholds for OTD and LD gratings. However, when the number of spatial samples per grating cycle exceeded about six, plots of both discrimination threshold and detection threshold were different for OTD and LD gratings. For an OTD grating of any given spatial frequency, spatial frequency discrimination threshold fell as the number of samples per grating cycle was increased while holding texture line length constant: the lower limit was reached at six to ten samples per cycle. When we progressively increased the viewing distance (keeping the cycles per degree (cpd) constant), spatial frequency discrimination threshold reached a lower limit and increased thereafter. We propose that this minimum threshold represents a balance between opposing effects of the number of samples per grating cycle and the length of texture lines, and approaches the absolute physiological lower limit for OTD gratings. Spatial frequency discrimination was possible up to at least 7 cpd. Grating acuity for an OTD grating was considerably lower than the physiological limit for LD gratings, presumably because detectors of OTD form include a spatial integration stage following the processing of individual lines. For an LD grating, discrimination threshold fell as the number of samples per grating cycle was increased and asymptoted at six to ten samples per cycle. Spatial frequency discrimination thresholds for OTD and LD gratings were similar at low spatial frequencies (up to 3-4 cpd), but increased more steeply for OTD gratings at high spatial frequencies. For both OTD and LD gratings, discrimination threshold fell steeply as the number of grating cycles was increased from 0.5 to ca. 2.5 cycles, and thereafter decreased more slowly or not at all suggesting that, for both OTD and LD gratings, spatial frequency discrimination can be regarded as a special case of line interval or bar width discrimination. As orientation contrast was progressively increased, discrimination threshold for an OTD grating fell steeply up to about four to five times grating detection threshold, then saturated. This parallels the effect of luminance contrast on discrimination threshold for an LD grating.

Adult↗
PubMed1998

Orientation-tuned spatial filters for texture-defined form.

Detection threshold for an orientation-texture-defined (OTD) test grating was elevated after adapting to an OTD grating of high orientation contrast. Threshold elevation was greatest for a test grating parallel to the adapting grating, and fell to zero for a test grating perpendicular to the adapting grating. We conclude that the human visual system contains an orientation-tuned neural mechanism sensitive to OTD form, and propose a model for this mechanism. We further propose that orientation discrimination for OTD bars and gratings is determined by the relative activity of these filters for OTD form.

Adaptation, Ocular↗
PubMed1998

Iodine-131 anti-B1 antibody for B-cell lymphoma: an update on the Michigan Phase I experience.

UNLABELLED: Iodine-131 anti-B1 antibody radioimmunotherapy for B-cell lymphoma was previously reported to have substantial antitumor activity in B-cell non-Hodgkin's lymphoma (NHL) after failures of standard and salvage chemotherapy. In this article, the University of Michigan Phase I clinical experience is updated, with follow-up of up to 6 yr since initial treatment reported. METHODS: Thirty-four patients with CD20-expressing NHL were first studied with one or more dosimetric doses of approximately 5 mCi of 1311 anti-B1 antibody (after varying predoses of unlabeled anti-B1 antibody). They were then treated with a patient-specific radioimmunotherapeutic dose designed to deliver a specified radiation dose to the whole body of between 25 and 85 cGy. Patients were observed for toxicity and tumor response. RESULTS: Seventeen (50%) patients had low-grade NHL, 9 (26%) had low-grade transformed NHL and 8 (24%) had de novo intermediate-grade NHL. At study entry, 17 (50%) had an elevated lactate dehydrogenase level, 12 (35%) had high tumor burden and 18 (53%) had not responded to their last chemotherapy. The median number of prior NHL therapies was 4.1. Twenty-eight of 34 patients completed treatment, with 22 of 28 (79%) achieving a response and 14 of 28 (50%) achieving a complete response (CR). The median duration of response was 357 days. The median duration of response for CRs was 471 days, with 4 CRs having a duration of > 1000 days (maximum = > 1460 days). Bone marrow toxicity was dose-limiting and dependent on the total-body dose (TBD) of radiation. Thrombocytopenia appeared to be more marked in patients with prior bone marrow transplantation. The TBD of 75 cGy was established as the maximum tolerated dose in patients who had not had prior bone marrow transplantation. Duration of CR was significantly longer (p < 0.04) in patients who received a TBD of 65-75 cGy (1109 days) than it was in those who received a lower TBD of 25-60 cGy (385 days). Four of 34 (12%) patients developed detectable human antimouse antibody levels. The median survival from study entry for all patients was 1508 days (range = 63 to >2226 days). Sixteen of 17 patients who achieved a response of > or = 6 mo duration remain alive. CONCLUSION: This update of the Phase I results after 1311 anti-B1 antibody treatment for NHL indicates that CRs can be durable and that survival can be of long duration. This form of therapy for NHL should have increasing application in clinical practice after confirmation of these results in larger multicenter studies.

Antibodies, Monoclonal↗
PubMed1997

Reversible dissociation of sensitivity to dynamic stimuli in Parkinson's disease: is magnocellular function essential to reading motion-defined letters?

A group of 20 control subjects carried out the following visual tests: Snellen acuity; contrast detection threshold for a temporally unmodulated grating and for a temporally modulated grating; speed threshold for recognising motion-defined dotted letters. Normal limits were defined as 2.5 standard deviations from the respective control means. A patient with Parkinson's disease carried out the tests 12 hr after medication was withheld at a time when symptoms were evident ("off" stage), and after administration of medication when it had taken full effect ("on" stage). Confirming previous reports, contrast detection threshold for the temporally modulated grating was much higher during the "off" stage than during the "on" stage, but contrast detection threshold for the temporally unmodulated grating showed little difference. Speed threshold for recognising motion-defined letters did not, however, fall during the "on" stage. We suggest that magnocellular function is not essential for the recognition of motion-defined form.

Contrast Sensitivity↗
PubMed1997

Vernier step acuity and bisection acuity for texture-defined form.

Using as the stimulus a texture pattern of short lines, we compared positional acuity thresholds for an orientation-texture-defined (OTD) boundary and a luminance-defined (LD) boundary. Texture lines had different orientations but the same luminance on either side of the OTD boundary, and different luminances but the same orientation on either side of the LD boundary. For the LD boundary, both vernier step acuity threshold and bisection acuity threshold were inversely proportional to the number of texture lines per degree (i.e., the pattern's spatial sampling frequency) over the entire 1.9-59 samples/deg frequency range investigated, though thresholds were considerably lower than the distance between adjacent lines. For the OTD boundary, both thresholds were inversely proportional to spatial sampling frequency (though thresholds were again considerably less than the distance between adjacent lines) but only for sampling frequencies below 20 samples/deg. For sampling frequencies below 20 samples/deg, the ratio between positional acuity thresholds for OTD and LD boundaries was approximately constant (3.5:1 for vernier acuity and 1.4:1 for bisection acuity). As sampling frequency was increased beyond 20 samples/deg both vernier and bisection acuity thresholds for OTD boundaries rose steeply. Both thresholds fell to a minimum near 20 samples/deg. For vernier step acuity the minimum threshold was 2.3 and 2.4 min arc (two observers), and for bisection acuity 1.7 and 1.9 min arc. We propose that these minimum thresholds approach a physiological limit of positional acuity for an OTD boundary, and that the limit is determined by a balance between the progressive improvement of positional acuity caused by increasing the frequency of spatial sampling vs the progressive reduction in visibility of the OTD boundary caused by the associated reduction in the length of texture lines. These physiological limits are far higher than the corresponding limits for sharp-edged high-contrast LD targets (2-5 and 1-5 sec arc, respectively). For an OTD boundary the effect of orientation contrast on vernier step acuity threshold approximated a square root law, while the effect of orientation contrast on bisection acuity approximated a linear law. Observers can combine positional information carried by texture contrast with positional information carried by luminance contrast. As to the combination rule, our findings are consistent with probability summation between independent channels.

Adult↗
PubMed1997

Discrimination of the direction and speed of motion in depth of a monocularly visible target from binocular information alone.

Thresholds for discriminating a monocularly visible object's direction of motion in depth and speed of motion in depth were measured using only binocular cues. Observers could discriminate the direction of motion in depth while totally ignoring speed and discriminate the speed of motion in depth while totally ignoring direction. Direction discrimination thresholds were the same for motion in depth within the vertical and horizontal meridians, even though a cue to trajectory was available for motion within the horizontal meridian that is not available for motion within the vertical meridian. Speed discrimination thresholds also were the same for motion in depth within the vertical and horizontal meridians. For the 3 observers the lowest direction discrimination thresholds were 0.14 degree, 0.18 degree, and 0.22 degree (means of horizontal and vertical thresholds).

Depth Perception↗
PubMed1997

Just-noticeable difference in the speed of cyclopean motion in depth and the speed of cyclopean motion within a frontoparallel plane.

Weber fractions for discriminating the speed and displacement of a cyclopean target moving in depth ranged, respectively, from .07-.17 and .06-.13 over 6 observers. Corresponding data for a noncyclopean target were .07-.20 and .06-.12. For motion parallel to the frontal plane, corresponding data were .09-.20 .06-.16, and .05-.13. All Weber fractions were independent of the direction of motion and of near versus far disparity. All observers based their judgments entirely on the task-relevant variable and ignored task-irrelevant variables in all cases. We conclude that speed and displacement are encoded independently and in parallel for motion in depth and for motion within a frontoparallel plane.

Adult↗
PubMed1997

Visual factors in hitting and catching.

To hit or catch an approaching ball, it is necessary to move a bat or hand to the right place at the right time. The performance of top sports players is remarkable: positional errors of less than 5 cm and temporal errors of less than 2 or 3 ms are reliably maintained. There are three schools of thought about how this is achieved. One holds that predictive visual information about where the ball will be at some future instance (when) is used to achieve the hit or catch. The second holds that the bat or hand is moved to the correct position by exploiting some relation between visual information and the required movement. The third focuses on the use of prior knowledge to supplement inadequate visual information. For a rigid spherical ball travelling at constant speed along or close to the line of sight, the retinal images contain both binocular and monocular correlates of the ball's instantaneous direction of motion in depth. Also, the retinal images contain both binocular and monocular information about time of arrival. Humans can unconfound and use this visual information, but they are unable to estimate the absolute distance of the ball or its approach speed other than crudely. In cricket, this visual inadequacy allows a slow bowler to cause the batsman to misjudge where the ball will hit the ground. Such a bowler uses a three-pronged strategy: first, to deliver the ball in such a way as to prevent the batsman from obtaining the necessary visual information until it is too late to react; secondly, to force the batsman to rely entirely on inadequate retinal image information; thirdly, to allow the batsman to learn a particular relationship between the early part of the ball's flight and the point where the ball hits the ground, and then to change the relationship with such skill that the batsman does not detect the change.

Algorithms↗