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Biomedical subjects

D Ramm

Publications and source records attributed to D Ramm.

12 recordsLinked to original sources
PubMed1994

Method for the description of differences in the filamentous structure of the cytoskeleton in cultured cells.

Over the last few years in vitro cell systems have been established for toxicological investigations. These systems permit the evaluation of effects on the basis of cultured cells in order to replace animal studies. Not only qualitative assessment of cytotoxic effects, but also efforts to quantify these intracellular changes have become more and more important to objectify the results which have been obtained. The cytoskeleton, a dynamic and sensitive system, seems to be a valuable morphological parameter to gain information about the intracellular alterations of drug-influenced cells. Depending on the dose of the substance administered, the cytoskeleton shows morphological alterations in specific components, which fulfill structural as well as metabolic regulatory functions and thus provide information on possible mechanisms. Normally, microtubules as well as the intermediate filament system from 3-dimensional networks. Treatment may induce contraction or depolymerization of the filamentous proteins. These alterations, seen in immunofluorescent preparations, can be quantified by means of a 2-dimensional Fourier transformation. As there is no statistical method to compare different spectra, the spatial frequency spectrum of the Fourier components has to be transformed to a 1-dimensional array. This step is performed by measuring the optical density of localised areas in the frequency spectrum. Using this transformation it is possible to compare the Fourier spectra belonging to different treatment groups.

Animals↗
PubMed1985

Accidental and homicidal death in a psychiatric emergency room population.

To identify potentially preventable mortality other than suicide among psychiatric emergency room patients, the authors compared the rates of accidental and homicidal death among 5,284 consecutive psychiatric emergency room patients with those expected for an age-, sex-, and race-matched sample of the general population. The rate of accidental death was two and one-half times and the rate of homicidal death nearly twice the expected rate for the matched general population. Diagnostic and demographic analyses indicated that increased risk of death from either cause was highest among alcoholics, schizophrenic patients, and males. The implications of the findings for clinical care are discussed.

Accidents↗
PubMed1983

Suicide in a psychiatric emergency room population.

Twenty-two suicides were identified in a series of 5,284 psychiatric emergency room patients, yielding a suicide rate of 111.1 per 100,000 "patient-years at risk"--more than seven times the age- and sex-adjusted rate for the general population. Subpopulations at high risk were white people, men, depressed and schizophrenic patients, substance abusers, and patients with multiple emergency room visits. No patients had killed themselves immediately after an emergency room visit, but several had killed themselves without following through on a referral from the emergency room to another facility for treatment. The authors discuss the implications of these findings for emergency room practice and for further research.

Adult↗
PubMed1981

Christmas and psychopathology. Data from a psychiatric emergency room population.

It is widely believed among psychiatrists and laymen alike that Christmas and other holidays are associated with an increased incidence of psychopathology. Statistical studies, however, consistently have been shown the Christmas season to be associated with a low incidence of suicide and psychiatric hospitalization. The present study examines the number and type of visits to a 24-hour psychiatric emergency service over a seven-year period. There is a decrease in the number of visits during the days and weeks before Christmas and an increase of roughly the same magnitude afterward. The effect is more prominent for women and older persons but does not seem to differentially affect persons of different racial, marital, or diagnostic status.

Adult↗
PubMed1980

Effects of alcohol on psychomotor performance of women: interaction with menstrual cycle.

The effects of alcohol on performance were investigated in 10 ovulating young women. Placebo drink and three doses of alcohol were administered in a random order both during follicular and luteal phases of the menstrual cycle. The women had significantly slower verbal information processing rate and poorer visual detection performance during the follicular than the luteal phase of the menstrual cycle. In psychomotor tasks other than tracking, dose--response relationships of alcohol were different during the different phases of the menstrual cycle.

Adult↗
PubMed1979

Stress and adaptation in later life.

The effects of five major life events, and of three types of resources, on the physical and social-psychological adaptation of 375 participants in a longitudinal study were examined. As expected, medical events had the most impact on physical adaptation, but they had surprisingly little impact on social-psychological adaptation. Retirement had the most negative social-psychological effects, but had little effect on physical adaptation. The other three events had even less effects, although multiple events tended to cumulate in impact. Better physical resources helped only physical adaptation, and better psychological and social resources mainly helped satisfaction. It appears that most of these potential stressors have less serious long-term outcomes than the crisis orientation would suggest.

Adaptation, Physiological↗
PubMed1975

Treatment goals in geropsychiatry.

Each geriatric patient has observable problems which can generate treatment goals implemented by a treatment plan. Extensive record keeping would be required to document this tripartite scheme. In practice, either problem-oriented or goal-oriented records are used. Problem records tend to drift toward a goal concept, since problems are usually stated in only sufficient detail to serve as a guide to treatment. The results of a problem-oriented format are described for 143 state hospital patients whose mean age was 74 years. The most common number of problems was 5 per patient. Physical problems were the most frequent (N equals 456), followed by behavioral (N equals 203), thought-related (N equals 156), administrative (N equals 99), affective (N equals 69), and attitudinal (N equals 10). The author's experience with both systems leaves them with preference for the problem-oriented system with geriatric patients since physical problems are so numerous.

Aged↗