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Biomedical subjects

D R White

Publications and source records attributed to D R White.

156 records · Page 9Linked to original sources
PubMedDate not supplied

Tissue substitutes in experimental radiation physics.

In this review of tissue substitute materials, the historical development of the important systems is traced from the early 1900's. Tabulations of the constituents, elemental compositions, specific gravities, and the photon and electron interaction characteristics of 64 materials are given together with recommendations of systems having useful simulation properties. Formulation and manufacturing procedures are described and possible future developments in both materials and phantom research are outlined.

Elementary Particles↗
PubMedDate not supplied

Hospital operations execs focus on human resource needs. Interview by Thomas G. Goodwin.

As part of its coverage on the human resource issues that will face hospital managers in the next few years, FAHS Review interviewed several of the investor-owned industry's most outspoken and respected, managers. Although the comments of these five executives range from a call for a complete overhaul of the administrative functions of the hospital to the early recruitment of young people into the health care industry, all agreed on one key point: the successful hospital manager of the 1990s will have to be savvy, tough, resourceful, flexible and innovative.

Hospital Administration↗
PubMedDate not supplied

Pharmacokinetics of vincristine infusion.

Using a sensitive radioimmunoassay, serial blood concentrations of vincristine were measured in 11 patients with refractory malignancies receiving infusions of vincristine at three dose levels: 0.5, 0.75, and 1.0 mg/m2 daily for 5 days. The pharmacokinetics of vincristine infusion were compared to pharmacologic data obtained from four patients who received conventional iv bolus injections of 2 mg of vincristine. Whereas rapid decline of blood levels was seen following iv bolus injection, with concentrations of vincristine approaching 10(-9) M by 48-72 hours, vincristine infusions of 0.5, 0.75, and 1.0 mg/m2 daily for 5 days consistently resulted in blood concentrations greater than 10(-9) M during the treatment period. Similarly, areas under the concentration curve were greater in patients receiving infusions compared to bolus injections of vincristine. Antitumor responses in patients receiving vincristine infusions were observed after failure to respond to iv bolus injections. These data demonstrate the ability of infusion therapy to sustain blood concentrations of vincristine in man beyond that seen with conventional administration and suggest the possibility of improved therapeutic efficacy with this agent by use of infusion techniques.

Adult↗