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Biomedical subjects

D R Triger

Publications and source records attributed to D R Triger.

At least 109 records · Page 6Linked to original sources
PubMed1975

Studies on hepatic uptake of antigen. III. Studies of liver macrophage function in normal rats and following carbon tetrachloride administration.

A technique of pronase digestion followed by density gradient centrifugation was used to study the morphology and phagocytic function of isolated rat liver macrophages in the normal rat and at varying times after the in vivo administration of carbon tetrachloride. Administration of the hepatotoxin results in a transient fall in the number of isolated macrophages. This deficit is corrected by a rapid influx of mononuclear cells from elsewhere in the animal which quickly differentiate into liver macrophages. Despite changes in the morphology of isolated macrophages, no evidence was found to suggest in vitro functional impairment of these cells. In vivo studies of intrahepatic shunting showed that this became a significant phenomenon 6 hours after the administration of the hepatotoxin. The enhanced antibody response to sheep red cells which occurs after carbon tetrachloride administration appears to be due to a series of events in which the decrease in the number of liver macrophages is an early significant factor, while intrahepatic shunting is a major contributing factor at a later time.

Animals↗
PubMed1974

Viral antibodies and autoantibodies in chronic liver disease.

Our previous observations of highly significant increases in high titre antibodies to measles and rubella in patients with chronic active hepatitis have been extended and it has been shown that these reactions do not occur in other forms of liver disease. Significant increases in antibody titres to cytomegalovirus have also been found in patients with chronic active hepatitis (p<0.001) and alcoholic and primary biliary cirrhosis (p<0.05). Antibody titres to herpes simplex, varicella/zoster, parainfluenza I, and Mycoplasma pneumoniae in all forms of chronic liver disease did not differ from controls. Immunofluorescent autoantibodies were correlated with the viral antibodies and a highly significant correlation with strongly positive antismooth muscle and antinuclear antibodies and measles antibody titres in particular was noted. The possible significance of this correlation is discussed in terms of the hypothesis that the intact liver plays a significant role in the sequestering of antigens.

Adolescent↗
PubMed1966

Survival of urinary leucocytes.

The survival of white cells under 15 mu in diameter (95% polymorphonuclear leucocytes), obtained from the urine of patients with urinary tract infections, was examined in vitro under different conditions of osmolarity, pH, and temperature of incubation. The rate at which urinary white cells disintegrate was found to be accelerated by raising the pH, decreasing the osmolarity, and by increasing the temperature at which suspensions were kept. The most rapid disappearance of white cells occurred in hypotonic alkaline suspension at 37 degrees C. There was little change in cell suspensions kept in acid (pH 3.0) or in hypertonic (1,200 mOsmoles/1.) conditions over a period of 24 hours. The findings indicate that in interpreting the significance of the number of leucocytes in urine it is necessary to take into account the condition of the urine and the time and temperature at which it has been kept before examination.

Humans↗
PubMedDate not supplied

The role of propranolol in congestive gastropathy of portal hypertension.

Heavy diffuse bleeding from congested gastric mucosa (congestive gastropathy) was treated by propranolol (dose = 24 to 480 mg per day) in 14 consecutive patients with portal hypertension. Thirteen patients (93%) stopped bleeding within 3 days. Gastric mucosal cherry red spots (a sign of severe gastropathy) were unchanged in 5 patients, became less obvious in 4 and appearances returned to normal in 5. Propranolol was discontinued electively in seven patients after 2 to 6 months; four of these patients rebled from the same lesion and stopped bleeding when propranolol was recommenced. No patient has rebled from congestive gastropathy while receiving propranolol during follow-up of 12 to 42 (median = 23) months. A further 24 patients with nonbleeding congestive gastropathy received 160 mg long-acting propranolol per day in a double-blind placebo controlled cross-over trial. Twenty-two patients completed the study; in nine patients, endoscopic grading of congestive gastropathy improved after propranolol compared to three after placebo (p less than 0.05). Although the mechanism of action is not understood, propranolol appears to have a clinically significant role in the management of nonvariceal gastric bleeding in portal hypertension.

Adult↗