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Biomedical subjects

D R Perera

Publications and source records attributed to D R Perera.

At least 37 records · Page 2Linked to original sources
PubMed1984

Antibiotic-associated colitis.

We determined the incidence of antibiotic-associated colitis among users of oral antibiotics or topical clindamycin in a large prepaid health plan. Exposure to antibiotics was determined using a system that automatically records outpatient prescriptions filled and hospital diagnoses were available from computer files. Four cases of acute colitis were judged likely to be causally linked with outpatient use of antibiotics. These findings provide substantial evidence that antibiotic-associated colitis requiring hospital treatment occurs very rarely.

Acute Disease↗
PubMed1983

Teaching sigmoidoscopy to primary care physicians: a controlled study of continuing medical education.

A sigmoidoscopy skills preceptorship was developed for physicians to increase the rate of sigmoidoscopy by physicians in a health maintenance organization. The preceptorship was designed as a randomized, controlled study of continuing medical education. Baseline sigmoidoscopy rates of participating physicians were similar to those of nonparticipants, as were selected demographic and professional characteristics. Physicians randomized to receive sigmoidoscopy training significantly increased their rate of sigmoidoscopy when compared with controls. The proportion of barium enemas accompanied by sigmoidoscopy likewise increased. All physicians who participated improved when compared with nonparticipants. The sigmoidoscopy skills preceptorship appears to be a worthwhile endeavor in continuing medical education.

Education, Medical, Continuing↗
PubMed1982

Vaginal spermicides and gonorrhea.

All positive cultures for neisseria gonorrhoeae recorded from Dec 20, 1978, through Dec 31, 1980, for women born between 1940 and 1960 were identified among members of Group Health Cooperative of Puget Sound, Seattle, and rates of gonorrhea were calculated for recent oral contraceptive users, recent vaginal spermicide users, and women with surgical sterilization. The risk ratio (RR) estimate, based on the included population, for spermicide users compared with all others was 0.23 (90% confidence interval [Cl], 0.10, 0.50). When women with positive cultures for N gonorrhoeae were compared with women with negative cultures, the RR estimate comparing spermicide users with all others was 0.13 (90% Cl, 0.05, 0.34). The results are consistent with the protective effect of vaginal spermicides against gonorrhea.

Adult↗
PubMed1976

Overwhelming watery diarrhea associated with a cryptosporidium in an immunosuppressed patient.

A 39-year-old man with severe bullous pemphigoid developed overwhelming diarrhea after 5 weeks' treatment with 150 mg of cyclophosphamide and 60 mg of prednisolone daily. Jejunal and ileal biopsies showed severe mucosal injury and tiny 2- to 4-mu organisms on the epithelial surfaces. Similar organisms were seen in smears of jejunal fluid. Electron microscopic examination of jejunal biopsies showed these spherical bodies to be trophozoites, schizonts, microgametocytes, and macrogametocytes typical of the genus Cryptosporidium. Diarrhea resolved 2 weeks after discontinuation of cyclophosphamide and coincided with disappearance of Cryptosporidia from the jejunal biopsies. Immunosuppression may have predisposed this patient to cryptosporidial diarrhea. Cryptosporidiosis is another infection which can be diagnosed by small bowel biopsy. When immunosuppressed patients develop severe diarrhea, opportunistic infection with this and other organisms should be considered as the possible cause.

Adult↗