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D R Nalin

Publications and source records attributed to D R Nalin.

108 records · Page 6Linked to original sources

Effect of glycine and glucose on sodium and water adsorption in patients with cholera.

Electrolyte solutions containing glucose, glycine, or a combination of the two were absorbed sufficiently well from the intestine to supply maintenance fluid and the electrolytes required by cholera patients. Data on net absorption and duration and volume of diarrhoea show that a solution containing both glucose and glycine provides more effective therapy than solutions containing either glucose or glycine alone.

Adolescent↗

Genetic susceptibility to cholera.

In the course of studies of immunity to experimental cholera in man, 10(5) or 10(6) Vibrio cholerae were given to 66 college students and other community volunteers under quarantine in an isolation ward. HLA antigen and blood group determinations were carried out to test the hypothesis that severity of clinical cholera is dependent in part upon genetically-determined host susceptibility. Fifty-five volunteers developed diarrhoea; 38 had mild illness and 17 had severe cholera (stool volume greater than or equal to 5.0 litres). HLA antigens were found in similar frequency in volunteers with severe, mild or no diarrhoea; antigen A1, A2, A3 and B7 were most common. Blood group O, however, was found in 64% of persons with severe cholera versus 36-38% of volunteers with mild or absent illness. Thus, while no correlation was found between HLA type and severity of cholera, these results do support the claims of other investigators that blood group O is found more frequently in patients with severe cholera than in the normal population.

ABO Blood-Group System↗

Measles vaccine.

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Gambia↗

[Rehydration by the oral route and its maintenance in patients from birth to 3 months old dehydrated due to diarrhea].

Studies of oral rehydration have been carried out in patients three months of age or older. With the exception of a previous report by us, nothing has been written before about the method of rehydration in patients of less than three month of age. During the period comprised between March 1978 and May 1979, we attended 106 patients; age ranging from seven days to three months and weighing 1,900 to 6,080 grams. The The dehydration status ranged from 2% - 4%; in all cases due to watery diarrhoea. Oral or nasogastric rehydration was accomplished in 97% of cases in an average time of seven hours. Several patients presented severe water and electrolyte unbalance, namely metabolic acidosis or hypernatremia. This returned near normality as the patients became rehydrated. We conclude that patients under 3 months of age respond as well as older ones to oral rehydration.

Administration, Oral↗