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Biomedical subjects

D R Jones

Publications and source records attributed to D R Jones.

At least 361 records · Page 20Linked to original sources
PubMed1978

Errors on doctors' prescriptions.

All prescriptions dispensed by one pharmacist during one month were examined for errors. Only 5.1 per cent of 2,237 prescription forms contained an error which meant the pharmacist had to contact the doctor. Thirty-seven per cent of prescriptions were either wholly or partly written by the receptionist. There was considerable variation between doctors and this varied from zero to 64 per cent; 4.0 per cent of prescriptions written by the doctor contained errors while those written by the receptionist were almost twice as likely (seven per cent) to do so. The majority of mistakes were obvious and trivial but five were potentially serious.It is recommended that if doctors expect their receptionists to write prescriptions they should ensure that they are adequately trained to do so. The pharmacist can be a valued and trusted colleague who serves to protect patients from doctors' errors.

Drug Prescriptions↗
PubMed1977

Maintenance of remission in acute myelogenous leukaemia by a mixture of B.C.G. and irradiated leukaemia cells.

Thirty patients with acute myelogenous leukaemia (A.M.L.) in full haematological remission were allocated alternately to two groups of fifteen patients each. All patients received immunotherapy, given weekly as intradermal and subcutaneous injections of killed allogeneic A.M.L. cells, plus Glaxo B.C.G. given by Heaf gun at a separate site. One group also received a mixture of A.M.L. cells and B.C.G. on 4 occasions early in remission. Four patients in this group have remained in remission for 92 to 134 weeks, whereas all patients in the other group had relapsed by 68 weeks. The findings suggest that cells mixed with B.C.G. may be effective in prolonging remission.

Adolescent↗
PubMed1977

Carbon dioxide sensitivity of pulmonary receptors in the frog.

Pulmonary mechano-receptors have been found in the frog lung that are sensitive to CO2 concentrations in the lungs and airways comparable to the physiological levels recorded in frogs. These results support the suggestion that a pulmonary receptor with distinct mechano- and chemosensitive properties may represent the functional precursor of the more specialized pulmonary receptor types which have evolved in birds and mammals.

Action Potentials↗
PubMed1977

A scanning electron microscope study of the microvasculature of the avian lung.

1. The microvasculature of the lung of the duck and pigeon was studied by scanning electron microscopy of vascular casts and critical point dried preparations of the gas exchange tissue. 2. The gas-exchange cappilaries are discrete tubular vessels intimately associated with air capillaries in a three dimensional network. 3. The capillaries originate from arteries at the periphery of the parabronchus, and are collected by veins which run close to its luminal surface. 4. The capillary bed of 3-5 atria is drained by a single vein. It is suggested that the vein and its associated capillaries may form a controllable subunit of pulmonary perfusion.

Animals↗
PubMed1977

A clotting defect in an Arab colt foal.

A multiple clotting defect in a 3 month old Arab colt foal associated with a deficiency in Factors VIII, IX, and XI is described. No abnormalities in clotting factors were detected in the colt's sire, dam, half-sister and half-brother.

Animals↗
PubMed1977

A follow-up of self-poisoned patients.

Over half the patients who were admitted to hospital after self-poisoning had seen their general practitioner in the previous month, and in half of those discharged from hospital no definite after-care arrangements were made. Opportunities for prevention of occurrences are being missed. Thorough follow-up of 135 such patients identified many non-medical problems, and over 80 per cent were helped by appropriate referral. Although only five of these patients made a further attempt during the period of review, the method of selection of patients does not allow definite conclusions to be made.

Aftercare↗
PubMed1977

Suicide by aircraft: a case report.

A 36-year-old pilot took his plane on a brief, unauthorized flight that ended in a high-speed vertical crash next to the runway. A retrospective "psychological autopsy" yielded strong presumptive evidence of an unrecognized depression in a man with manipulative and mildly antisocial characteristics. His withdrawal from his usual patterns of behavior was, instead, regarded as a desirable return to "normal" behavior. This case report includes comments on the role of the psychological autopsy in aircraft accident investigation, anniversary reactions, the use of psychiatric diagnosis to support the agreed-upon decision on the desired disposition, some aspects of subintentional suicidal behavior, a brief review of the literature on suicide by aircraft, and consideration of the role of the flight surgeon in preventing such occurrences through early recognition of depression.

Adult↗
PubMed1976

The effects of asphyxia on afferent activity recorded from the cervical vagus in the duck.

Recordings were made of nervous activity from duck arterial chemoreceptors, arterial baroreceptors and pulmonary receptors during steady-state conditions (normoxic normocapnia, hypoxia, and hypercapnia) and apnoeic asphyxia. Arterial chemoreceptors were stimulated by hypoxia and intra-arterial KCN injection and showed an increasing discharge throughout asphyxia. During the first 2 min of asphyxia the time course of the development of asphyxic bradycardia paralleled that of the increase in arterial chemoreceptor discharge. Arterial baroreceptors discharged at a constant latency from the heart beat when mean arterial pressure was constant, while a drug-induced increase in mean arterial pressure was associated with a reduced latency and increased baroreceptor activity per heart-beat. During asphyxia mean arterial pressure often rose so that, despite the effect of bradycardia, baroreceptor activity per heart-beat and activity per unit time increased. Pulmonary receptors showed a linear relationship (negative slope) between discharge rate and % CO2 in inspired air and usually stopped firing in apnoeic asphyxia. The initiation and maintenance of diving bradycardia are discussed in terms of these results.

Animals↗
PubMed1976

Plasma fibrinolysis and postoperative deep vein thrombosis.

In 23 high risk patients the change in plasminogen activator activity in response to surgical operation was studied by euglobulin lysis time (ELT) and fibrin plate lysis before, during and for up to 6 days following a major surgical procedure. Fibrin degradation products (FDP) were also measured. The aim was to relate any changes to postoperative deep vein thrombosis (DVT) as diagnosed by the 125I fibrinogen test. Peroperative increase and postoperative inhibition of fibrinolytic activity were seen in all the patients. Changes in fibrinolytic activity as measured by the ELT and during the first 24 hours by the fibrin plate technique were similar. This suggests that during this period the response was independent of plasma fibrinogen changes. There was no significant difference in these parameters between patients who developed DVT and those who did not. The relationship between venous thrombo-embolism and elevation of serum FDP was confirmed.

Female↗