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Biomedical subjects

D R Henderson

Publications and source records attributed to D R Henderson.

At least 37 records · Page 2Linked to original sources
PubMed1989

Endoscopic sphincterotomy in the management of benign and malignant extrahepatic biliary obstruction.

One hundred twenty-one patients with extrahepatic biliary obstruction underwent endoscopic sphincterotomy (EST). This was followed by balloon occlusion catheter or dormia basket stone extraction in 106 patients with choledocholithiasis, and by transpapillary biliary endoprosthesis placement in 15 patients with malignant distal common bile duct obstruction. All patients had excellent biliary decompression. Complications not requiring surgical intervention were seen in six patients. This article shows that EST is a low-risk, effective therapy for benign and malignant extrahepatic biliary obstruction.

Adolescent↗
PubMed1989

Percutaneous transluminal angioplasty of stenosis at the common iliac artery origin using a single-balloon technique.

The "kissing balloon" technique has been recommended for percutaneous transluminal angioplasty of common iliac stenoses located at or near the aortic bifurcation, because of the theoretical risk of contralateral embolization or stenosis if a single balloon is used. A single-balloon technique was used to dilate 20 atherosclerotic stenoses at this site in 19 patients. Technical success was achieved in 18. No complications occurred. Follow-up studies at intervals ranging from three to 51 months showed a patency rate similar to that achieved with the kissing balloon method. We believe that the use of kissing balloons is unnecessary since single-balloon angioplasty is safe and effective.

Adult↗
PubMed1988

Pancreatic abscess associated with pancreas divisum.

Pancreas divisum has been implicated as a cause of pancreatitis. Pseudocyst development in association with chronic pancreatitis has also been observed in a few patients with this anomaly. The association of pancreatic abscess with pancreas divisum has not been observed previously. The case herein reported illustrates a coincidental finding of pancreas divisum in a patient who presented with a pancreatic abscess.

Abscess↗
PubMed1988

Early gastric cancer in clinical practice.

A description of four patients with early gastric cancer diagnosed by endoscopy is reported. All patients presented with type III (excavated or ulcerative) early gastric cancer. Early gastric cancer appeared to be slow growing in three patients, and was difficult to diagnose in two cases, especially when associated with large gastric ulcers. Endoscopic biopsy of nonhealing or recurrent gastric ulcers and endoscopic follow-up to complete ulcer healing are recommended.

Adult↗
PubMed1987

IgG (kappa) paraproteinaemia and arthritis.

Three patients with IgG (kappa) paraproteinaemia in association with inflammatory polyarthritis are described. Two of the patients had an erosive deforming arthritis, and the third had a non-erosive arthritis and necrotizing vasculitis. Possible aetiological relationships between the paraproteinaemia, arthritis and vasculitis are discussed.

Arthritis↗
PubMed1986

Swing beds: an approach to hospital utilization.

The need to use every available space for productive purposes is becoming a major concern for hospitals, especially rural hospitals. This need, coupled with the decline in the building of nursing homes, has given rise to the concept of the swing bed, a hospital bed that can be used to provide care to either acute or long-term care patients. This ability allows an acute care hospital to provide care to patients who might traditionally receive care in a nursing home.

Aged↗
PubMed1986

CEDIA, a new homogeneous immunoassay system.

Genetic engineering of beta-galactosidase (EC 3.2.1.23) has led to the development of a new homogeneous assay system, CEDIA. The Z gene of the lac operon of Escherichia coli encodes a large enzymatically inactive polypeptide that spontaneously aggregates and folds to form active beta-galactosidase. Using recombinant DNA techniques, we have been able to engineer beta-galactosidase protein into a large polypeptide (an enzyme acceptor, EA) and a small polypeptide (an enzyme donor, ED). The EAs and EDs are both enzymatically inactive, but spontaneously associate to form enzymatically active tetramers. In the assay, hapten or analyte is attached to an ED, and an analyte-specific antibody is used to inhibit the spontaneous assembly of active enzyme. Analyte in a patient's serum competes with the analyte in the analyte-ED conjugate for antibody, modulating the amount of beta-galactosidase formed. The signal generated by enzyme substrates is directly proportional to the analyte concentrations in the patient's serum. We describe quick (5-15 min) colorimetric tests for digoxin, requiring no serum pretreatments or predilutions and suitable for use with centrifugal and random-access analyzers.

Amino Acid Sequence↗
PubMed1985

Endoscopic sphincterotomy in clinical practice.

Endoscopic sphincterotomy was performed in 22 patients with biliary obstruction. Nineteen patients had obstructing choledocholithiasis and three patients had distal common-bileduct obstruction due to malignant disease. All patients had excellent biliary decompression. Three patients had complications that responded to medical management. Endoscopic sphincterotomy is a safe and effective procedure for the nonsurgical management of obstructive-biliary-tract disease.

Adult↗
PubMed1976

Spontaneous osteonecrosis of the medial femoral condyle.

Six patients with osteonecrosis of the medial femoral condyle were seen during a 3 1/2-year period in a rheumatology unit. This condition, which may not be rare, is characterized by the sudden onset of pain in the knee of elderly people (usually women) without significant trauma. Physical signs include effusion and tenderness at the medial margin of the knee joint. Radiographic changes may not be evident for weeks or even months. The later appearances are characteristic and the site of the lesion is remarkably constant.

Aged↗
PubMed1975

Vertical atlanto-axial subluxation in rheumatoid arthritis.

In a prospective survey of 476 hospital in-patients with rheumatoid arthritis, vertical atlanto-axial subluxation (AAL) was found in 13 patients (3.7 per cent). All were women with severe rheumatoid arthritis. Neurological signs were found in ten patients, and in seven they appeared to be due to vertical AAL. The signs caused by vertical AAL were diminished pain and temperature sensation in the upper divisions of the trigeminal nerve, sensory loss in the areas supplied by C2, nystagmus and pyramidal lesions. Disabling involvement due to vertical AAL was not found although it may occur and the lesion may be fatal. The lower cervical spine was involved in all patients and severe lesions were seen in nine. The most severe neurological lesions appeared to be due to subaxial subluxation. Corticosteroid therapy may have been a contributing factor in four patients.

Adult↗
PubMed1975

Synovitis in polymyalgia rheumatica.

Synovitis was observed in 13 out of 88 consecutive patients with polymyalgia rheumatica. It is described in detail in five patients, on the basis of clinical radiological observations, joint aspiration, arthroscopy and biopsy. The synovitis of polymyalgia rheumatica cannot be distinguished histologically or at arthroscopy from the appearance seen in mild rheumatoid arthritis. Clinically, however, the synovitis of polymyalgia rheumatica is mild, transient and confined to one or two joints or tendon sheaths. It is not followed by joint deformity or by radiological erosive changes in the bone ends. It may occur at any stage of the disease but particularly at its onset, or when the dose of corticosteroid treatment is reduced.

Aged↗
PubMed1975

Lack of correlation of synovial histology with joint damage in rheumatoid arthritis.

Twenty-two patients with rheumatoid arthritis (RA) involving the knee were studied. The systemic features of the disease were graded and the extent of knee involvement was quantified in terms of the clinical, radiological, and arthroscopic appearances. Adequate synovial biopsies were obtained from 21 patients. In these patients no correlation could be found between the severity of any of the features on histological examination nor between any of these features and the extent of local joint damage, inflammation, or the severity of the systemic disease.

Arthritis, Rheumatoid↗