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Biomedical subjects

D R Hadden

Publications and source records attributed to D R Hadden.

207 records · Page 12Linked to original sources
PubMedDate not supplied

The effects of one month high fructose intake on plasma glucose and lipid levels in non-insulin-dependent diabetes.

The effects of a high fructose diet on the control of blood glucose and serum lipids were studied in 10 non-insulin-dependent diabetic patients (mean age 64.4 years, mean duration of diabetes 5.6 years). Comparison was made following 28 days on the usual diabetic diet and 28 days during which 25% of the usual carbohydrate was substituted with fructose. There was no change in mean (+/- SEM) fasting plasma glucose (on usual diet 9.2 +/- 0.5 mmol/l, on fructose diet, 9.1 +/- 0.4 mmol/l), but there was a fall in mean plasma glucose levels at 30, 60, and 120 min in a 75 g OGTT following the fructose diet. There was no significant change in fasting lipids: on usual diet mean serum cholesterol 5.8 +/- 0.2 mmol/l, on fructose diet 5.6 +/- 0.2 mmol/l; serum triglyceride, on usual diet 1.3 +/- 0.1 mmol/l, on fructose diet 1.3 +/- 0.1 mmol/l; HDL cholesterol on usual diet 1.4 +/- 0.1 mmol/l, on fructose diet 1.4 +/- 0.1 mmol/l. Mean body weight did not vary significantly between the two diets. Incorporation of fructose into the diabetic diet may lower post-prandial glucose levels without disturbing serum lipids.

Aged↗
PubMedDate not supplied

Influence of sample type on the interpretation of the oral glucose tolerance test for gestational diabetes mellitus.

The World Health Organization (1985) criteria allow evaluation of the oral glucose tolerance test using venous or capillary whole blood or plasma glucose measurements. However, the empirical factors used for interconversion may not reflect observed differences, especially during pregnancy, causing inconsistent classification. To investigate how choice of sample would influence the interpretation of results, venous and capillary blood was taken during oral glucose tolerance tests in 36 pregnant women at risk of gestational diabetes and in 21 non-pregnant control subjects. Glucose was measured on whole blood and plasma by a glucose oxidase method. No cases of gestational diabetes were identified. Eight subjects had gestational Impaired Glucose Tolerance using either venous plasma or venous whole blood results, but only five were similarly classified with capillary whole blood and only four using capillary plasma. Plasma-whole blood differences (venous 0.6 +/- 0.2 (+/- SD) mmol l-1, capillary 0.7 +/- 0.3 mmol l-1) and capillary-venous differences (plasma 0.5 +/- 0.4, whole blood 0.4 +/- 0.5 mmol l-1) at 2 h were lower (all p less than 0.05) than in the WHO criteria (1.1 mmol l-1). When compared with venous plasma, capillary measurements may give a lower incidence and venous whole blood measurements a higher incidence of Impaired Glucose Tolerance in pregnancy.

Adult↗
PubMedDate not supplied

Bedside blood ketone body monitoring.

The use of a reagent strip and reflectance meter for the bedside measurement of 3-hydroxybutyrate during the clinical management of diabetic ketoacidosis is described. Comparison of this method with a laboratory enzymatic assay shows good correlation (r = 0.97, p less than 0.05). Initial use in acute ketoacidosis suggests that knowledge of hourly changes in 3-hydroxybutyrate levels could be helpful in determining the optimum insulin dose.

3-Hydroxybutyric Acid↗
PubMedDate not supplied

Screening for abnormalities of carbohydrate metabolism in pregnancy 1966-1977: the Belfast experience.

Of the 30,300 mothers who attended consecutively at the antenatal clinic during an 11-yr period, 3063 mothers screened positive using clinical criteria for potential diabetes in pregnancy. These 3063 mothers had a glucose tolerance test (GTT), of which 661 were judged abnormal. At different times an oral GTT, cortisone-stressed GTT, or i.v. GTT were used and several changes in the clinical screening criteria and interpretation of the GTT values were made. There was a steady fall in fetal loss in all groups of mothers during the period. Those mothers whose glucose intolerance was between one and three standard deviations above the mean had only slightly more pregnancy complications than those with a normal GTT. Apart from clicnial recognition of this state, no special management of these mothers was necessary. Long-term decompensation of glucose tolerance to frank or symptomatic diabetes was uncommon.

Adult↗