The antimetastatic and tumor growth retarding effects of sulfur containing analogs of nicotinamide.
Several sulfur containing 5- and 6-membered heterocyclic carboxylic acids (or esters) were shown to decrease the number of pulmonary metastases in C57BL/6 mice implanted with Lewis lung carcinoma. The numbers of such metastatic nodules were reduced more than 5-fold. In addition, these compounds, which could be viewed as analogs of nicotinamide, were shown to inhibit the growth rate of the primary implanted tumor by about 50%.
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