Biomedical subjects

D R Glover

Publications and source records attributed to D R Glover.

21 records · Page 2Linked to original sources

PubMed1982

Assessment of left-ventricular mass and its response to antihypertensive treatment.

50 patients with mild to moderate essential hypertension underwent M-mode echocardiography and continuous intra-arterial ambulatory monitoring of blood pressure. Indices of left-ventricular (LV) mass were derived from echocardiographic data by standard formulae. 43 of the patients were followed up for 12+/-7 months with repeat M-mode echocardiography, and casual blood-pressure measurements. 25 of these patients received antihypertensive therapy and 18 were untreated. Mean 24 h systolic blood pressure was significantly correlated with echocardiographic LV mass; mean 24 h diastolic blood pressure was also correlated, but the relation was weaker. In the treated group there was a significantly greater fall in blood pressure and LV mass index than in the untreated group, and there was a significant correlation between the fall in systolic blood pressure and the fall in LV mass index in the treated group. Systolic blood pressure appears to be an important factor in the pathogenesis of LV hypertrophy, and in hypertensive patients changes in LV mass assessed by echocardiography correlate with changes in blood pressure.

Adolescent↗

PubMed1982

Control of blood pressure and reduction of echocardiographically assessed left ventricular mass with one-daily timolol.

1 Ten untreated hypertensive patients underwent 24 h continuous intra-arterial ambulatory monitoring of blood pressure (BP) and M-mode echocardiography. 2 They were treated with once-daily timolol and followed up at 2, 4, 8 and 12 weeks when dosage was titrated against BP control (indirect measurement) and degree of beta-adrenoceptor antagonism (submaximal bicycle ergometry and sub-lingual GTN). 3 Sixteen weeks after commencing therapy, nine patients underwent repeat continuous ambulatory monitoring of BP and M-mode echocardiography. 4 Casual BP was significantly reduced during the follow-up period at 2, 4, 8 and 12 weeks. 5 A reduction of BP was seen throughout the 24 h although this did not achieve statistical significance when sympathetic activity was low. 6 Echocardiographic measurement of left ventricular mass was significantly reduced after 16 weeks treatment.

Adrenergic beta-Antagonists↗

PubMed1981

The relationship between ambulatory blood pressure and echocardiographically assessed left ventricular hypertrophy.

1. Continuous intra-arterial ambulatory monitoring of blood pressure was recorded in 46 patients with mild to moderate hypertension under standardized conditions. M-mode echocardiography was performed after recording and left ventricular mass index calculated by standard formulae. 2. Systolic blood pressure from continuous recording was significantly correlated with left ventricular mass index (mean 24 h: r = 0.543, n = 45, P less than 0.001). Diastolic blood pressure exhibited a weaker but still significant correlation with left ventricular mass index (mean 24 h: r = 0.318, n = 45, P less than 0.05). Casual systolic blood pressure was significantly correlated with left ventricular mass index (r = 0.476, n = 46, P less than 0.001) but casual diastolic blood pressure did not correlate with left ventricular mass index (r = 0.245, n = 46). Awake blood pressure variability, age, resting plasma renin activity and resting plasma noradrenaline levels did not have a significant correlation with left ventricular mass index. 3. Nine patients were treated for 16 weeks with once-daily timolol and repeat ambulatory monitoring and M-mode echocardiography was performed with the same protocol. 4. Once-daily timolol provided good 24 h control of blood pressure and repeat echocardiography showed a reduction in left ventricular mass index in that group of patients (t = 2.59, P less than 0.05).

Adolescent↗