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Biomedical subjects

D R Finco

Publications and source records attributed to D R Finco.

At least 55 records · Page 3Linked to original sources
PubMed1988

Effect of atropine on cystometry and urethral pressure profilometry in the dog.

Effects of atropine on cystometry and urethral pressure profilometry were examined in 12 healthy young adult dogs by comparing recordings obtained after xylazine alone with those obtained after administration of xylazine and atropine. Significant differences (P greater than 0.05) were not found, indicating that atropine, when administered SC with xylazine, did not markedly affect cystometrographic results and urethral pressure profiles.

Animals↗
PubMed1987

Lesions in dogs following renal transplantation and immunosuppression.

Renal allografts were transplanted into 20 dogs (12 beagles, eight mongrels) following a prescribed protocol for pre-transplantation blood transfusions and kidney exchange. Immunosuppressive therapy (azathioprine and prednisone) was modified as needed for each dog. Seven of the beagle dogs survived for 1 year and were then euthanized; all other dogs died or were euthanized prior to 1 year post-transplantation. Graft rejection and renal failure were the greatest causes of mortality. Renal lesions which contributed to the death of some animals included renal vein thrombosis, nephrosis, and pyelonephritis. Inflammation of the lower respiratory tract (bronchitis, pneumonia, and pleuritis) was a contributory cause of death in some dogs. Cystitis and ureteritis occurred in almost half of the dogs. Prostatitis was seen in six of the 16 male dogs. Adrenal cortical atrophy, parathyroid gland hyperplasia, and bone marrow hypocellularity were seen in a majority of the dogs which survived 1 year.

Animals↗
PubMed1986

Canine prostatic diseases.

Prostatic diseases such as benign hyperplasia, prostatic cysts, acute bacterial prostatitis, chronic bacterial prostatitis, prostatic abscessation, and prostatic neoplasia are discussed. Also discussed are diagnostic techniques such as prostatic palpation and massage, evaluation of semen and urethral discharge, and radiography.

Animals↗
PubMed1986

Food and water intake and urine composition in cats: influence of continuous versus periodic feeding.

Twenty healthy, noncastrated, adult male cats had periodic (11 am to 12 am) or continuous (24 hours daily) access to food. With periodic feeding, cats ate less food, drank less water, and produced less urine than when food was available continuously. The composition of urine obtained by cystocentesis at 7:30 am, 3:30 pm, and 10 pm was influenced somewhat by feeding pattern. With periodic feeding, urine pH was lower at 7:30 am and higher at 3:30 pm than it was with continuous feeding. Most mineral concentrations and urine osmolality-specific gravity did not differ with the different feeding schedules. However, when periodic feeding was used, concentrations of magnesium and phosphorus in urine were as high or higher preprandially (7:30 am) than postprandially (3:30 pm). Frequency of urination per 24 hours was not influenced by the feeding schedule, but the time that urination occurred during the 24-hour period was somewhat different. An experimental, high magnesium diet fed to the cats for 200 days caused urethral obstruction in 7 of 10 cats fed periodically and in 7 of 10 cats fed continuously. Cats with obstruction had urinary mineral concentrations similar to concentrations in cats without obstruction, indicating that urinary mineral concentration may not be the only factor relevant to the process of obstruction. Necropsy findings and histologic evaluation of tissues from the cats indicated incidental lesions or abnormalities caused by urethral obstruction, but did not indicate anatomic abnormalities that would have predisposed the cats to obstruction.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1985

Kidney graft survival in transfused and nontransfused sibling beagle dogs.

In 6 pairs of sibling Beagle dogs, 1 kidney was exchanged between pairs, and contralateral nephrectomy was done. Previously, one dog of each pair was given blood transfusions from the donor of its allograft. All dogs were given azathioprine and prednisone postoperatively for immunosuppression. Four of 6 dogs given pretransplantation transfusions were healthy 1 year after surgical manipulation was done, and 2 died for reasons other than graft rejection. Of the 6 dogs that were not given pretransplantation transfusions, 3 were healthy after 1 years, but 2 were euthanatized because of graft rejection, and the last was euthanatized because of both graft rejection and intussusception. Other complications in these dogs were leukopenia (7 dogs), interdigital abscesses (2 dogs), urinary infection (3 dogs), and renal vein thrombosis (1 dog). Considering the lack of alternative methods for effective therapy for chronic renal failure in dogs, results of this study seem encouraging for selective use of renal transplantation, clinically. This study supports previous reports which indicated that pretransplantation transfusion enhanced graft survival in dogs.

Animals↗
PubMed1985

Characterization of magnesium-induced urinary disease in the cat and comparison with feline urologic syndrome.

Aggregates of struvite crystals caused urethral obstruction in a high percentage of cats fed moist and dry diets supplemented with Mg oxide. Some of the diets were associated with cystolith formation as well. The percentage of Mg in the experimental diets was a misleading indicator of Mg intake because of differences between moist and dry diets in their caloric density. Magnesium homeostasis was maintained in cats ingesting large quantities of Mg. Tissue (kidney, muscle, and rib) concentrations of Mg were the same in cats fed high Mg and control diets. Plasma Mg concentration was increased only in cats ingesting the largest amount of Mg. Magnesium homeostasis was maintained by a marked increase in urine Mg excretion. However, urine Mg concentration was not directly related to Mg intake, apparently because of differences between diets in intestinal absorption of Mg. Urethral obstruction of experimental cats was not associated with a transient increase in Mg intake, nor did obstructing cats have higher urine Mg concentrations than did nonobstructing cats fed the same diet. This observation indicates that factor(s) other than urine Mg concentration are important in urethral obstruction. Cats with urethral obstruction due to naturally occurring disease, feline urological syndrome (FUS), had markedly lower urine Mg concentrations than cats fed high Mg diets. This finding refutes the theory that cats develop FUS because of primary Mg hyperabsorptive phenomena or because of a primary urinary leak of Mg. It also indicates that factors other than urine Mg concentration are involved in the genesis of naturally occurring urethral obstruction. Another difference between the natural and the induced disease was related to the character of the urinary precipitates. Experimental diets higher in Mg concentration caused urolith formation, which is uncommon with FUS. Lower Mg diets caused obstruction with aggregates of crystals, but mucus was not observed. However, in the experimental disease induced in the present study, urinary precipitates were predominantly or exclusively struvite, as has been reported in the natural disease. Many similarities were seen between the diet-induced disease and FUS, but factors in addition to Mg intake are involved in the natural disease. The importance of Mg, compared with the undefined factors, remains to be established.

Animals↗
PubMed1985

Effects of three diets on dogs with induced chronic renal failure.

Healthy mixed-bred dogs of both sexes had renal mass surgically reduced and were allowed 2 to 3 months for hypertrophy of the remnant kidney. They were then allotted into 3 groups with equal renal function and were fed 1 of 3 diets that differed in composition. Group 1 dogs (n = 6) were fed moist food that contained 50% protein, 2.34% Ca, and 1.64% P with a P-binding agent (basic aluminum carbonate gel) added. Group 2 dogs (n = 6) were fed a dry diet that contained 24.5% protein, 1.26% Ca, 1.21% P, and the same P-binding agent as used for group 1. Group 3 dogs (n = 7) were fed a moist diet that contained 16.1% protein, 0.38% Ca, and 0.3% P without a P-binding agent. Each group was fed its diet for 92 days and monitored for responses. Mortality associated with uremia occurred in 2 of 6 group 1 dogs, 0 of 6 group 2 dogs, and in 2 of 7 group 3 dogs. Among survivors, clinical signs were seen in the more azotemic dogs of group 1, but not in dogs of groups 2 and 3. The blood urea nitrogen, plasma P concentrations, and PCV values were most favorable in group 3 and least favorable in group 1. Marked differences between groups were not seen in plasma concentrations of protein, albumin, or Ca or in plasma alkaline phosphatase activity. Values for glomerular filtration rate did not change in any group during the experiment.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1985

Mechanism of renal excretion of creatinine by the pony.

Free-flow and stop-flow procedures conducted on 2 female and 2 testosterone-treated castrated male ponies indicated that [14C]inulin and exogenous creatinine clearance values were the same. These results indicated that creatinine was neither reabsorbed nor secreted by the renal tubules and that exogenous creatinine clearance was an accurate method for determining glomerular filtration rate. As in other species which have been studied, endogenous creatinine clearance probably underestimated glomerular filtration rate because of the presence of noncreatinine chromogens in plasma.

Animals↗
PubMed1984

Effect of immunosuppressive drug therapy on blood urea nitrogen concentration in dogs with azotemia.

Azotemic dogs receiving prednisone and azathioprine to enhance renal allograft survival had higher blood urea nitrogen (BUN):serum creatinine (SC) ratios, when compared with nontreated dogs with induced azotemia. The difference in ratios probably was attributable to increased BUN content secondary to the catabolic effects of the drugs used. However, dogs with naturally occurring renal failure had BUN:SC ratios that were similar to those for dogs receiving the catabolic drugs. It was concluded that even though catabolic drugs may influence BUN:SC ratios, the multiplicity of other factors affecting BUN and SC may interact to cause a wide range of BUN:SC ratios under conditions of naturally occurring primary renal failure in the dog.

Animals↗
PubMed1984

Evaluation of techniques for diagnosis of canine prostatic diseases.

Bacterial culture and cytology of semen, bacterial culture and cytology of prostatic fluid washings, urinalysis, bacterial culture of urine, and blood leukocyte counts were performed on specimens from dogs with prostatic hyperplasia, chronic prostatitis, or prostatic neoplasia. Hemorrhage was the most frequent abnormal finding in semen from dogs with prostatic hyperplasia. Inflammation was the most frequent abnormal finding in dogs with chronic prostatitis. Bacterial culture of semen was sensitive but not specific for chronic bacterial prostatitis, due to false-positive results from urethral contamination. Hemorrhage was the most frequent abnormal finding in prostatic fluid washings from dogs with prostatic hyperplasia. Inflammation was the most frequent abnormal finding in dogs with chronic prostatitis. Abnormal epithelial cells were found after prostatic massage in 4 dogs with neoplasia, although these cells were difficult to identify as neoplastic. Prostatic fluid washings were not useful for detecting chronic bacterial prostatitis, due to an inability to detect increases in bacterial counts in the fluid when urine bacterial counts were high. Hematuria was the predominant abnormal finding in urinalysis from dogs with hyperplasia and neoplasia. Pyuria was the most frequent abnormal finding in dogs with chronic prostatitis. Urine was usually culture-positive when there was prostatic infection. Blood leukocyte counts were normal in dogs with prostatic hyperplasia and usually normal in dogs with neoplasia. Leukocytosis, a left shift, and toxic white blood cells were predictive of abscessation, although the blood leukocyte count was not a very sensitive indicator for infection without abscessation.

Animals↗
PubMed1984

Effects of an anabolic steroid on acute uremia in the dog.

Four groups of dogs made acutely uremic were treated with placebo, 0.5 mg/kg, 1.0 mg/kg, and 1.5 mg/kg of an anabolic steroid (3-oxo-delta 1,4 androstadiene-17 beta-ol-undecylenate). Pretreatment and posttreatment measurements of food intake, body weight, PCV, serum creatinine concentration, plasma albumin concentration, nitrogen balance, lean body mass, and limb circumference did not indicate any beneficial effect of this drug in this model of acute uremia.

Animals↗
PubMed1982

Effect of dietary phosphorus restriction on the kidneys of cats with reduced renal mass.

Cats with reduced renal mass were fed a phosphorus-restricted diet (0.24% P, dry weight) or a normal phosphorus diet (1.56% P, dry weight) for 6 5 to 343 days. Renal function was determined biweekly by blood urea nitrogen and plasma creatinine measurements and by initial and terminal inulin clearance procedures. Neither diet caused a significant change in renal function during the study. However, histologic examination of kidneys obtained at necropsy clearly separated the cats on the basis of dietary phosphorus. The kidneys from cats fed the normal phosphorus diet had mineralization, fibrosis, and mononuclear cell infiltration, whereas the kidneys from cats fed the phosphorus-restricted diet had little or no changes.

Animal Feed↗
PubMed1982

Mechanism of urinary excretion of creatinine by the cat.

Creatinine and [14C]inulin clearance values were nearly the same during stop-flow and free-flow conditions in the cat. We conclude that glomerular filtration is the sole factor in renal excretion of creatinine in this species. Anatomic (bladder vs kidney) and dynamic (slow vs fast urine flow rate) studies indicated insignificant changes occurred in creatinine content of urine as it traversed the ureter and bladder of cats. We conclude that the cat ureter and bladder under conditions of moderate distension are relatively impermeable to creatinine.

Animals↗
PubMed1981

Efficacy of ethylenediamine dihydrochloride in dogs and cats.

Ethylenediamine dihydrochloride was administered to dogs and cats with induced Escherichia coli urinary tract infections and to clinically normal dogs and cats to determine if the drug had diuretic, antibacterial, or urinary acidification properties. In dogs, the drug had no diuretic or antibacterial properties and did not modify the postprandial production of alkaline urine. In cats, the drug had no diuretic or antibacterial properties, but caused a slight reduction in urine pH when multiple doses were administered. Ethylenediamine dihydrochloride appeared to have no value in the treatment of E coli urinary infection under the conditions of the present study.

Animals↗
PubMed1981

Renal function after prolonged hypotensive anesthesia and surgery in dogs with reduced renal mass.

The effect of prolonged hypotensive anesthesia and surgery on renal function was studied in 8 dogs with decreased renal mass. Renal mass was reduced by unilateral nephrectomy and ligation of 4 of the 6 terminal renal artery branches of the opposite kidney. One week after reduction in renal mass, the dogs were azotemic with a serum urea nitrogen (SUN) value of 65.8 +/- 11.5 mg/dl. Glomerular filtration rate, as estimated by 14C-inulin clearance, was 0.66 +/- 0.19 ml/kg of body weight/hour. A mean arterial pressure of less than 75 mm of Hg was maintained for 4 hours in dogs given 2.3 +/- 0.7% halothane. An exploratory laparotomy lasting 1 hour was performed. The day after the hypotensive episode, 3 dogs began vomiting, became dehydrated, and had SUN values greater than 100 mg/dl. The SUN values returned to base-line values after the dogs were rehydrated. Eight days after the hypotensive episode, 14C-inulin clearance decreased 15.2 +/- 8.2% (P less than 0.005) compared with base-line clearance values. Light microscopic and electron microscopic observations of the kidneys did not demonstrate acute renal failure. Prolonged hypotensive anesthesia can cause a decrease in renal function, and may cause prerenal uremia and/or acute renal failure.

Anesthesia, Inhalation↗