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Biomedical subjects

D R Burger

Publications and source records attributed to D R Burger.

66 records · Page 4Linked to original sources
PubMed1972

Transfer factor from guinea pigs sensitive to dinitrochlorobenzene: absence of superantigen properties.

Transfer factor from guinea pigs sensitive to dinitrochlorobenzene was not bound to an immunoadsorbent column that is specific for the dinitrophenyl determinant. The absence of the dinitrophenyl determinant on transfer factor suggested that the factor does not function as superantigen. The duration of the adoptive sensitivity, the small molecular weight, and the polypeptide or polynucleotide (or a combination) composition of the transfer factor are consistent with a derepressor function of the molecule.

Animals↗
PubMed1971

Delayed Hypersensitivity Induced in Guinea Pigs by 7, 12-Dimethylbenz(a) anthracene.

A delayed hypersensitivity to 7, 12-dimethylbenz(a)anthracene was elicited in guinea pigs after contact sensitization. This sensitivity was characterized by its time of appearance, histology, specificity, and transfer characteristics. The reaction had its maximal dermal reactivity 24 hr after challenge, was characterized by a mononuclear cell infiltration, demonstrated immunological specificity, and could be transferred with leukocytes to normal animals.

Journal Article↗
PubMed1971

Cell-free passive transfer of delayed hypersensitivity to chemicals in guinea pigs.

Delayed-type cutaneous reactivity to 2,4-dinitrochlorobenzene and 2,4-dinitrofluorobenzene in guinea pigs was transferred passively by fluids in which leukocytes from sensitive animals were incubated. Cells from peritoneal exudates, lymph nodes, and alveolar washings were employed. The cell-free transfer material was dialyzable, of small molecular size, and stable to 56 C for 30 min and -65 C for at least 9 weeks. It gave a ratio at 280 to 260 nm of 0.71. The relationships between temperature, pH, and cellular release of the transfer material were studied.

Animals↗
PubMedDate not supplied

Assessment of immunocompetent cells in patients with head and neck squamous cell carcinoma.

Patients with squamous cell carcinoma of the head and neck have impaired T cell function and poor tumor-specific responsiveness. Disproportionate levels of circulating immunocompetent cells could be one reason for this diminished immunity. In this study, a panel of monoclonal antibodies and flow cytofluorometry were used to define the relative proportions of selected immune cell populations. We detected a deficiency of the interleukin-2-producing subset of T helper-inducer cells (TH 5.2+) in these patients. Our data showed no significant differences in circulating levels of total T cells, T cell subsets, B cells, monocytes, or natural killer cells when compared to age, alcohol- and tobacco-use matched controls.

Aged↗