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Biomedical subjects

D R Brebbia

Publications and source records attributed to D R Brebbia.

10 recordsLinked to original sources
PubMed1979

Effects of loxapine on the sleep of chronic schizophrenics.

The sleep patterns of four male chronic schizophrenic patients were monitored throughout the various phases of a 1-year therapeutic trial with loxapine succinate, a newly developed neuroleptic. Compared with the initial drug-free baseline, the early drug period was characterized by an increase in REM percentage, REM density, and REM activity. During the drug maintenance period, the increase in REM phasic events was accompanied by an increase in total sleep. Severe insomnia was noted during the initial period of drug withdrawal. The absence of time lag between changes in drug administration schedule and the associated alterations in sleep patterns was in contrast with the time latency of the therapeutic response. This neuroleptic on sleep and on psychopathology are mediated by different mechanisms.

Adult↗
PubMed1965

Oxygen consumption rate and electroencephalographic stage of sleep.

In five male subjects, and a total of 15 man-nights, oxygen consumption rate (V(02)) was related to stage of sleep, as defined by electroencephalograms. Gross periodic variations which paralleled change in stage of sleep were discernible in analogue metabolic records. Computations revealed significant differences (P <.01) between all stages with V(02) highest in stage I REM (dreaming sleep), least in stages III and IV (deep sleep), and intermediate in stage II (light sleep).

Adult↗