Spike-wave complexes in "normal" flying personnel.
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Adult↗
Biomedical subjects
D R Bennett
Publications and source records attributed to D R Bennett.
Effects of the interaction of the ovary with an androstane nitrile on the uterus of the rat.
The compound 17 cyano-5,16 androstadien-3 beta-ol-acetate (cyanoacetate) was considered as a promising candidate for use as a contraceptive agent, since it was reported to specifically inhibit the ovarian conversion of pregnenolone to progesterone. A preliminary study in rats indicated that this compound had unique properties that interfered with the interpretation of results concerning the decidual response. It appeared to interact with the ovaries of the animal to cause an increase in uterine weight. Because of these observations, a multiple factorial study was designed to determine whether this compound was, in fact, more uterotrophic in intact, than in spayed, psuedopregnant rats. The study demonstrated that the presence of the ovary resulted in a significantly greater uterine weight, while 2 mg progesterone daily for 10 days had no significant effect on uterine weight. Cyanoacetate (10 mg/day for 10 days) was found to increase uterine weight significantly in intact, but not spayed, psuedopregnant rats. Neither cyanoacetate (10 mg/day) nor progesterone (2 mg/day) affected ovarian weight. The data suggest that cyanoacetate is converted by the ovary from a compound with little uterotrophic activity to a material with substantial uterotrophic activity.
Androstadienes↗
Migraine precipitated by head trauma in athletes.
Three members of a university football team were evaluated because of migraine symptoms precipitated by head trauma. Analysis of the clinical data from these cases, as well as eight previously reported in athletes, reveals that the head trauma is usually minor and not associated with amnesia; and, after a symptom-free interval most often of several minutes, visual, motor, sensory, or brainstem signs and symptoms begin. These usually last for approximately 15 to 30 min and are followed by headache frequently accompanied by nausea and vomiting. In 9 of 11 cases, attacks have occurred with subsequent head trauma. Only 4 of the 11 athletes admitted to spontaneous episodes, however, the incidence may be higher since they have not been followed by a sufficient period of time. Prophylaxis with antimigrainous drugs does not appear to be indicated. The decision as to future participation in contact sports is based primarily on the results of a thorough neurologic evaluation. The possible long-term sequela of this apparent "benign" condition, particularly in those athletes with repeated episodes, is not known since the entity has only recently been recognized. A migraine attack occurring in the course of an athletic event, particularly contact sports, can simulate a serious neurologic emergency. Despite its frequency in the general population and a propensity for onset in the first three decades of life, migraine has not been appreciated in the past as a possible significant sports medicine problem.
Adolescent↗
Cerebellar hemangioblastoma with prominent stromal astrocytosis: diagnostic and histogenetic considerations.
A cerebellar hemangioblastoma with atypical radiologic and morphologic features is reported. On computed tomography this tumor presented as a single ring-enhancing mass in the right cerebellar hemisphere without adjacent cyst formation. It was radiologically indistinguishable from an abscess or malignant neoplasm. Postmortem examination demonstrated a circumscribed, cystic neoplasm arising in the pia at the base of a sulcus. Microscopically, the tumor contained a prominent astrocytic component that mimicked the appearance of a highly vascular astrocytoma. Hemangioblastomas with this degree of astrocytosis are unusual. They must be distinguished pathologically from both cystic astrocytoma and mixed hemangioblastoma-glioma (angioglioma).
Aged↗