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Biomedical subjects

D R Averill

Publications and source records attributed to D R Averill.

32 records · Page 2Linked to original sources
PubMed1977

Inherited necrotizing myelopathy of Afghan hounds.

Eleven examples of a naturally occurring, adolescent-onset spinal cord necrosis in Afghan Hounds were studied. Unusual and characteristic spinal cord lesions were necrosis and small vessel proliferation in the dorsal and ventro-medial spinal cord white matter extending from caudal cervical segments to cranial lumbar segments. Spinal cord gray matter and dorsal and ventral roots were preserved. Four dogs had histologically similar lesions in the superior olivary nucleus. The cause of these lesions was not determined by histopathologic or ultrastructural examination. Chi-square analysis of pooled sibships indicates a simple autosomal recessive mode of inheritance.

Animals↗
PubMed1976

Hereditary cerebellar cortical and extrapyramidal nuclear abiotrophy in Kerry Blue Terriers.

Ten Kerry Blue terriers from a kennel in New York and 3 from a kennel in California developed clinical signs of a progressive cerebellar disorder, with its onset between 9 and 16 weeks of age. In 9 sequential necropsies, progressive cerebellar cortical degeneration, with loss of Purkinje's cells, was demonstrated. As the disease progressed, there was bilateral symmetric degeneration of the olivary nuclei followed by degeneration of the substantia nigra and caudate nucleus, bilaterally. The California and New York dogs were related, and an autosomal recessive inheritance was proposed for the disease.

Animals↗
PubMed1974

Brain polymorphonuclear leukocyte quantitation by peroxidase assay.

Rat brain polymorphonuclear infiltration was quantitated by spectrophotometric assay of myeloperoxidase activity. Peroxidase was assayed by following the oxidation of o-dianisidine in the presence of a hydrogen peroxide generating system (glucose-glucose oxidase). Enzyme activity was proportional to the number of polymorphonuclear leukocytes present at densities between 10(5) and 10(6) cells. Brain tissue did not have detectable peroxidase activity and polymorphonuclear leukocytes added to brain homogenates were quantitatively estimated. In infant rats with Haemophilus influenzae meningitis, the correlation between the number of polymorphonuclear leukocytes found in brain by peroxidase activity measurement and independent histological grading was not precise, but there was an exact correlation in predicting presence or absence of polymorphonuclear leukocytes. Myeloperoxidase activity appears to afford a rapid convenient tool for quantitative determination of tissue polymorphonuclear leukocyte content.

Aniline Compounds↗
PubMed1973

Production of Haemophilus influenzae b meningitis in infant rats by intraperitoneal inoculation.

Sprague-Dawley rats have a marked age-related susceptibility to Haemophilus influenzae type b that does not correlate with serum bactericidal activity. Eighty percent of 5-day-old animals that survive to 48 h after an intraperitoneal inoculation of a mean lethal dose of bacteria have histologically documented meningitis. Animals surviving the inoculations as infants manifest cerebral dysfunction as adults. This model should facilitate experimental study of bacterial meningitis.

Age Factors↗
PubMedDate not supplied

Laryngeal paralysis-polyneuropathy complex in young Rottweilers.

Five Rottweiler puppies from 3 unrelated litters developed inspiratory stridor at 11-13 weeks of age. Physical examination disclosed tetraparesis in all dogs, and bilateral lenticular cataracts in 4 dogs. Laryngeal examination under light anesthesia showed laryngeal paralysis in all dogs. Electrodiagnostic testing revealed denervation potentials in the distal appendicular muscles of 4 dogs tested and in the intrinsic laryngeal muscles of 2 dogs tested. Motor nerve conduction velocity was slightly low in 1 dog. Neurogenic muscular atrophy was found in distal appendicular muscles (n = 3) and intrinsic laryngeal muscles (n = 2), and degenerative changes were found in peripheral nerves (n = 3) and recurrent laryngeal nerves (n = 2). No abnormalities were detected in the spinal cord, spinal nerve roots, or ganglia of 3 dogs autopsied. The clinical, electrophysiologic, and histopathologic findings support a diagnosis of polyneuropathy and resemble the finding reported in young Dalmatians. Young dogs with laryngeal paralysis should be evaluated neurologically to rule out a more generalized polyneuropathy. The condition is suspected to be hereditary in nature and the prognosis is poor.

Animals↗