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Biomedical subjects

D R Alonso

Publications and source records attributed to D R Alonso.

67 records · Page 4Linked to original sources
PubMed1976

Pathogenesis of massively bleeding colonic diverticulosis: new observations.

Colonic diverticulosis is a common cause of acute severe rectal hemorrhage. The precise site of bleeding, etiology, and pathogenesis have not been previously identified. Arteriographic, microangiographic, and detailed histologic observations in 10 cases of massively bleeding colonic diverticulosis demonstrated strikingly consistent changes related to the characteristic angioarchitecture of colonic diverticula. These changes included: (1) asymmetric rupture of the vas rectum toward the lumen of the diverticulum precisely at its dome or its antimesenteric margin; (2) conspicuous eccentric intimal thickening of the vas rectum, often with thinning of the media and duplication of the internal elastic lamina at and near the bleeding point; and (3) general absence of diverticulitis. Comparison with control colonic diverticula suggests that traumatic factors arising within the diverticular or colonic lumen induce asymmetric intimal proliferation and segmental weakening of the associated vas rectum, predisposing to rupture and massive bleeding.

Adult↗
PubMed1976

Pathogenesis of bleeding colonic diverticulosis.

The cause of bleeding was found in 8 of 10 cases of colonic diverticulosis associated with severe rectal hemorrhage by using arteriographic and microangiographic techniques to localize the site and serial histological sections to study the lesion. Strikingly consistent changes were identified. These are related to the characteristic angioarchitecture of colonic diverticula. These changes include asymmetric rupture of the vas rectum toward the lumen of the diverticulum precisely at its dome or antimesenteric margin; conspicuous eccentric intimal thickening of the vas rectum, often with medial thinning of duplication of the internal elastic lamina at and near the bleeding point; and general absence of diverticulitis. Control colonic diverticula demonstrated normal structures or, only occasionally, minimal eccentric intimal thickening in their associated vasa recta. This suggests that traumatic factors arising within the diverticular or colonic lumen induce asymmetric intimal proliferation and scarring of the associated vasa recta, predisposing to rupture and massive bleeding.

Angiography↗
PubMed1975

Transpyloric extension to duodenal bulb in gastric lymphoma.

Gastric lymphoma may present in a spectrum of morphologic patterns which may mimic a variety of diseases clinically, endoscopically, radiologically and surgically. From its common location within the gastric antrum, transpyloric submucosal spread frequently occurs to involve the duodenal bulb and occasionally the proximal descending duodenum. This distinctive pathologic characteristic results in contour deformities, filling defects, and ulcerations of the duodenum which can be traced in continuity from the gastric lesions. These radiological observations are significant in the preoperative diagnosis of primary malignant lymphoma of the stomach and in the evaluation of disseminated lymphoma.

Duodenal Neoplasms↗
PubMedDate not supplied

Transcatheter embolization with Gelfoam and Avitene: the effect of Sotradecol on the duration of arterial occlusion.

Selective catheterization and embolization of both profunda femoris arteries were performed on eight mongrel dogs. In four dogs, Gelfoam alone (one side), and Gelfoam soaked in Sotradecol (contralateral side) was the embolic agent. In the other four dogs, Avitene in saline (one side), and Avitene suspended in Sotradecol (contralateral side) was the embolic agent. Ateriography followed by sacrifice and histologic examination were performed at two weeks (two dogs in each group) and two months (two dogs in each group) following embolization. In all dogs, histology confirmed the arteriographic appearance. In Gelfoam-embolized dogs, arteries embolized with Gelfoam alone were recanalized by two weeks; arteries embolized with Gelfoam/Sotradecol remained occluded at two months. In Avitene-embolized dogs, arteries embolized with Avitene in saline were moderately recanalized by two weeks and totally recanalized by two months; arteries embolized with Avitene/Sotradecol remained occluded at two months. Inflammatory changes were present in the walls of arteries embolized with Sotradecol. Sotradecol greatly increases the duration of arterial occlusion in Gelfoam and Avitene-embolized arteries.

Animals↗