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D Quietzsch

Publications and source records attributed to D Quietzsch.

20 records · Page 2Linked to original sources

[The problem-oriented case report--a method for the improvement of clinical training].

Abroad in the clinical education of the students the problem-oriented case report after Weed stood the test as a new training principle. In contrast to the classical case report the complaints and findings are formulated as problems and summarized in a list of problems. As problem is regarded what needs a diagnostic or therapeutic solution or a change of the patient's behaviour. For solution of the problem in a second step, the plan, the establishment of the ways of solution for every problem is done. In the notices of the course, the third part, the newly got findings are distributed to the adequate problems and their valency for the solution of the problem is tested. As advantages for the training are regarded: the establishment of the problems is more complete, the classification of psychic, social and health-educational problems is simpler. The physician is compelled to go over from the fixation on an individual problem to the valuation of all problems and to the correlations of several problems. Thus in the increasing specialisation an integrating role belongs to the problem-orientated case report. Independent formulation of the problems, development of the diagnostic and therapeutic steps, classification and valuation of their results in the notices of the course further the own responsibility of the student and renders possible a better control for the clinical instructor. The problem-oriented case report also forms the prerequisites for a problem-related letter of the physician.

Education, Medical↗

Comparison of the tumor associated proteases cathepsin D (CATH D) and urokinase-type plasminogen activator (uPA) in cytosols of human breast cancer patients.

As a matter of routine, prepared cytosols of human primary breast cancer specimens (n = 230) are analysed for both CATH D and hormone receptor status (ER,PR). Retrospectively, uPA was determined in the samples. The selection criterion for the retrospective analysis was the possibility of a longitudinal follow-up of the patients. All tumor stages were included, but the main emphasis was on lower tumor stages (T1, and T2) as well as nodal negative stages (N0). The results of the hormone receptor status (ER,PR) were: ER+PR+ 66.37%; ER+PR- 10.18%, ER-PR+ 10.18%, ER-PR- 13.27%. The CATH D results ranged from 5 to 246 pmol/mg protein. 30.97% of these results rose above 50 pmol/mg protein (positive), 42.48% were below 35 pmol/mg protein (negative). The uPA results ranged from 0.05 to 3.74 ng/mg protein. 27.43% of the uPA results rose above 0.71 ng/mg protein (positive), 58.85% were below 0.53 ng/mg protein (negative). Raised results of uPA are distinct in the higher tumor stages (T1N0 > T2N0 > T2N1 > T4Nx). Although the CATH D and uPA measurements showed similar results (positive/negative distribution) in the general survey, the confirmity of both factors is rather limited if it is focused to single cases. Between CATH D and uPA there was a confirmity of 50% (T1N0) of 45.5% (T2N0) respectively in the range of positive results, and there was a confirmity of 60.3% (T1N0) and 65.8% (T2N0), respectively, in the range of negative results. Differences were seen in 19.2% (T1N0) and 22.7% (T2N0), respectively, in the range of positive results, and in 20.6% (T1N0) in 1508% (T2N0), respectively, in the range of negative results. The prospectively diagnostic value of these is still under observation.

Biomarkers, Tumor↗