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Biomedical subjects

D Querleu

Publications and source records attributed to D Querleu.

At least 181 records · Page 10Linked to original sources
PubMed1981

[Epidemiological aspects of the foetal alcoholism syndrome. 45 cases (author's transl)].

During a prospective study conducted in Roubaix, 45 neonates presenting with the craniofacial malformation characteristic of the foetal alcohol syndrome were identified over a 3-year period. Twelve had signs of severe alcoholic embryo-foetopathy. This condition, which affects one in 700 neonates, occurs in multiparous women (mean age, 33 years) of low socio-economic status suffering from long standing, complicated alcoholism. Although the mean ethanol blood level may be as high as 1.82 g/l, this substance does not seem to be the only teratogenic agent.

Adult↗
PubMed1981

[Auditory perception and fetal reaction to react to sound stimulation (author's transl)].

The confirmation of techniques used to stimulate the fetus in utero led us to an exhaustive study of spontaneous intra-uterine noises and those modified by different stimuli (while evaluating the diagnosis of fetal distress with flat cardiac rhythm during pregnancy). By the use of elaborate techniques simultaneously we could appreciate the signal and analyse the information obtained and we able to show incontrovertibly that over and above the basal sound that the fetus could hear it could appreciate the mother's voice and other voices, which were perfectly audible to it but lacking in tone because the sharp frequencies were absorbed. The first results of stimulation using calibrated sounds seem to confirm that the fetus does not react to a sound stimulus when it is in a state of fetal distress, but when there is no fetal distress it does react immediately by change in the heart rate, often associated with movements. This technique, incidentally, can be used to show if the fetus can hear well in the uterus in cases of family deafness or of rubella associated with pregnancy.

Acoustic Stimulation↗
PubMed1981

[Working out a system for the parameters of intra-uterine pressure wave forms. A comparative study of spontaneous labour and induced labor (author's transl)].

The tracings of intra-uterine pressure changes that are made during normal labours in primiparous patients, whether the labours were normal or accelerated with oxytocin, were analysed using a semi-automatic time-lag with the help of system of 25 parameters. The classical data of pressures and of time have been made up with a study of the minima and maxima of pressure measurements and the drawing up of new indices to characterise the pressure wave form. A study of the correlations between the different groups of parameters made it possible to make a summary of the information from a smaller number of data which were identical for the two groups of delivery. In particular working out the surfaces dose not seem to give extra information over and above that derived from a simple calculation of the length and intensity of the contractions. A comparative statistical study confirms that in accelerated labour there is a rise in the basal tone, in the maximum pressure and in the frequency of contractions, and shows a minimal scatter of the values obtained which demonstrated that oxytocin has a regulating effect. Using parameters for the shape of contractions, quite independently of the units chosen to measure, has made it possible to design a typical form for the graph for each group of labours.

Female↗
PubMed1981

[Telemetric transmission of fetal cardiac rhythm in monitoring high risk pregnancies (author's transl)].

Telemetric transmission of fetal cardiac rhythm using a fetal electro-cardiographic signal which has been picked up from the mother's abdomen made it possible to monitor the fetus from a distance in 44 patients. This method of investigation, which is very demanding on the team, should be reserved for high-risk fetal cases. It makes it possible in some cases to pick up an early diagnosis of acute fetal distress, outside the times that are usually given for observations of fetal monitoring, namely multiples of ten minutes. The limitations in this technique are not to be found in the method of transmission itself, which does seem to be fairly easy to achieve successfully, but in the quality of the electro-cardiographic signals received from the abdominal wall, which are unreliable.

Adult↗
PubMed1979

[A study of gamma-glutamyl-transpeptidase and of the ratio of IgA to transferrin in the pregnant woman (and when using oral contraception) and in the newborn (author's transl)].

The authors confirm the absence of a marked variation in levels of gamma-glutamyl-transpeptidase in women under the influence of oestrogens, but a considerable rise in this enzyme in the newborn, particularly after delivery following vaginal obstetrical manoeuvre. They base these findings on 242 samples taken from pregnant women in the 3 trimesters of normal pregnancies and after delivery, and in the cord blood of newborn infants as well as in patients taking oral contraception. There is a slight rise in the levels of immunoglobulins A in the 3rd trimester of pregnancy. The overall rise in the blood levels of transferrin under the effect of oestrogens is confirmed. Norms were obtained for the levels of the IgA/T ratio which drops progressively as pregnancy progresses and with oral contraception. It has been found that in the last two trimesters the upper limit of the normal is 1 for the IgA/T ratio as compared with 1.9 in the general population. The study of these constants is of value when screening for maternal alcoholism and as a consequence for the prevention of the fetal alcohol syndrome.

Contraceptives, Oral↗
PubMed1979

[Invasive carcinoma of the uterine cervix associated with pregnancy (author's transl)].

In 4,396 invasive cervix carcinomas treated between 1934 and 1973, 52 occurred during pregnancy or within 3 months post partum. Stages I were more frequent among pregnant women (24%) than without pregnancy (8%) and stages II were as frequent (50%). Stages I and II were more frequent among pregnant women treated during 1963-1973 than 1934-1962. The 3 years' survival rate, all stages combined, for pregnant women (42%) was lower than for matched control non-pregnant women (62%). This difference was significant at P = 0.05, but at 5 and 10 years, the difference was not significant for patients treated between 1963-1973. At an equal stage, survival rate seemed lower for stages IIb and III (P = 0.02 for these two stages combined.) The lymph node involvement was not more frequent; the decrease of global survival rate could be associated to some factors and especially incomplete therapy and an under-estimation of the tumor extension because of the pregnancy. Our results are compared to the data literature and therapeutic schedules are discussed.

Abortion, Therapeutic↗
PubMed1978

[The effect of amniofetography on the fetal thyroid (author's transl)].

Although there are certain advantages of amniofetography they must be considered against the risk of fetal hypothyroidism "in utero" with its prognostic danger. The authors report six case histories which illustrate this risk and they draw attention to the possible effect on the thyroid gland "in utero". Amniofetography should therefore be reserved solely for those cases in which the indications exist and there are no other possible means of diagnosis. If it is indicated means must be found of treating the possible transitory iatrogenic hypothyroidism.

Adolescent↗