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Biomedical subjects

D Proud

Publications and source records attributed to D Proud.

186 records · Page 11Linked to original sources
PubMedDate not supplied

Clinical and immunologic effects of component peptides in Allervax Cat.

Peptides have been designed to be T cell tolerogenic for the principal allergens of the cat. These have been administered in several dosage programs to cat-sensitive patients in multicenter blinded studies. In contrast to proteins in standard extracts, IgE sensitization to peptides is an uncommon event. Pretreatment prick tests with peptides will identify the occasional sensitized patient. Other side reactions consist of allergic symptoms occurring on the day of injections. These become less severe with subsequent injections and are easily treatable with antihistamines or bronchodilators, depending on the symptoms. Treatment with cat peptides ameliorated symptoms that occur upon exposure to cats 1-6 or more weeks later. A 2-week course of 4 injections is the most effective of the regimens so far tried. T-cell-active peptides offer a promising low-risk alternative for specific treatment of respiratory allergies.

Allergens↗
PubMedDate not supplied

Effect of alterations in extracellular fluid volume on urinary kallikrein in the conscious rat.

The effect of alterations in extracellular fluid volume (ECV) and solute concentration on excretion of urinary kallikrein was examined in conscious Sprague-Dawley rats. Animals were given infusions of either dextrose and water, saline, or albumin according to a variety of protocols. These were designed to evaluate possible relationships between excretion of kallikrein, volume, sodium, and potassium. A reproducible pattern of kallikrein excretion was noted in all volume expanded groups. This consisted of a short lived increase during the initial hour of expansion with a subsequent fall to lower levels than baseline and a gradual recovery. To define the role of aldosterone in these studies, an adrenalectomized group and a group of appropriately prepared sham controls were expanded with saline. Adrenalectomy did not effect this pattern. We postulate a tubular "washout" phenomenon as the etiology of these observations. Results of these studies fail to demonstrate a consistent relationship between urinary volume, sodium, or potassium and the simultaneous amount of kallikrein found in the urine.

Adrenal Glands↗
PubMedDate not supplied

The role of kinins in human allergic disease.

We have provided clear evidence that kinins are generated during local allergic reactions in man and have begun studies on the mechanisms by which kinins are formed during these reactions. Clearly, the extent to which kinins may contribute to the symptomatology of allergic rhinitis remains to be determined, but the levels of kinins detected in the model systems described above are sufficient to cause relatively profound physiologic effects. In addition to its ability to produce vasodilatation and edema, bradykinin has been reported to stimulate fluid production from airway submucosal glands via a reflex action and could function to increase mucus production and cause rhinorrhea. Kinins have also been shown to increase chloride transport in the airway and to stimulate the production of prostaglandin E2 by epithelial cells. Thus we believe kinins must now be considered as potentially important mediators in the pathogenesis of human allergic diseases.

Humans↗