Search PubMed⌕ Search

Biomedical subjects

D Platt

Publications and source records attributed to D Platt.

At least 109 records · Page 6Linked to original sources
PubMed1990

Pharmacokinetics of drug overdose.

Drugs ingested in overdose can have altered pharmacokinetics of absorption, distribution, and elimination. The pathophysiologic consequences of overdose can also change a drug's pharmacokinetic properties. Many toxicologic interventions are based on modifying the drug's pharmacokinetics (e.g., impairing absorption or enhancing elimination). Serum drug monitoring, even with its limitations, does have a role in managing the patient who has taken an overdose.

Absorption↗
PubMed1989

[Geriatric day clinics and rehabilitation].

If the present development of our population is not to result in a continued increase in care-requiring elderly people, the building and expansion of geriatric rehabilitation institutions is a matter of urgency. Numerous studies, some of which carried out in our own country, show how successful geriatric rehabilitation can be. Prerequisites are, apart from appropriately equipped facilities, the proper selection of those requiring care, adequate numbers of properly qualified personnel, and early initiation of any treatment needed. Thus, 70 to 80% of those originally scheduled for admission to an old persons' nursing home can be enabled to live more or less independently at home. Apart from geriatric hospitals, geriatric day clinics offer optimal possibilities for rehabilitation. They combine therapeutic effectiveness and economy with the advantage that, during treatment, the elderly person is not completely taken out of his familiar surroundings, which results in an improvement in his motivation to get well again quickly. At the same time, complicating diseases, such as, for example, diabetes mellitus, can be treated under conditions closely similar to those of the patient's subsequent day-to-day situation. In this sense, geriatric day clinics are not only desirable, but urgently needed institutions.

Activities of Daily Living↗
PubMed1989

Pharmacokinetics of tiaprofenic acid in geriatric patients with ischemic heart disease.

The serum levels of tiaprofenic acid were determined by HPLC in 20 geriatric patients with ischemic heart disease, and the pharmacokinetic parameters were calculated. The results indicate that in geriatric patients the drug does not accumulate when given at a dose of 300 mg twice a day. Sufficient plasma levels are reached and the short terminal phase half-life prevents accumulation. The electrolyte balance was examined during the 7 days of treatment, and no change in sodium and potassium levels in the serum or in urine were observed. Weight as well as blood pressure of the patients remained constant, so that an increased development of edema, especially with regard to the existing ischemic heart disease of the patients, could be excluded. The results of our study indicate that tiaprofenic acid at the employed dosage is suitable for the therapy of arthritis in geriatric patients suffering from ischemic heart disease, without accumulation of the drug or the development of edema.

Aged↗
PubMed1989

Pharmacokinetics of ranitidine in geriatric patients with multiple diseases.

Ranitidine pharmacokinetics was measured after intravenous administration of 50 mg of the drug in 18 geriatric patients suffering from multiple diseases. Elimination half-life was prolonged (3.05 +/- 0.58 h) and total clearance was reduced (282 +/- 97 ml/min) as compared to the results of studies on normal younger persons by other investigators. In comparison to other studies on healthy elderlies, the pharmacokinetic parameters of ranitidine were only slightly different. Statistical analyses showed correlations of pharmacokinetic parameters of ranitidine with creatinine clearance, serum creatinine, uric acid concentration and alkaline phosphatase activity. These results disclose that reduced creatinine clearance or serum creatinine concentration in the upper normal range, for example, might serve as indicators for a possible dose reduction of ranitidine to prevent unnecessary overmedication in elderly patients.

Aged↗
PubMed1989

Pharmacokinetics of triamterene in geriatric patients--influence of piretanide and hydrochlorothiazide.

Pharmacokinetics of triamterene (single oral dose of 50 mg) and its pharmacologically active metabolite (OH-TA-ester) were determined in 20 geriatric patients with multiple diseases. Mean peak concentration of triamterene was increased in the elderly patients compared with the data of young healthy volunteers. Coadministration of piretanide seems to lower the mean plasma concentration (AUC) and the mean concentration after 24 h of triamterene as compared with the coadministration of hydrochlorothiazide.

Aged↗
PubMed1989

My past.

Explore the source record for details and available documents.

Attitude of Health Personnel↗
PubMed1988

Steady-state kinetics of bezafibrate retard in hyperlipidemic geriatric patients.

The pharmacokinetics of a slow-release formulation of bezafibrate were investigated under steady-state conditions in 19 hyperlipidemic patients between the age of 61 and 87 years and compared to the kinetics in 20 healthy volunteers (age 19-42 years). Maximum serum levels were 1.6-fold higher in the elderly, which was partly due to a diminished renal clearance caused by the reduction in renal function (CLCR 23-81 ml/min) and partly due to a decrease in extrarenal clearance (probably hydroxylation and hydrolysis). Evidence for the additional decrease in extrarenal clearance was provided by the greater decline in total drug clearance than would be anticipated from a mere reduction in glomerular filtration. Thus, dose adjustment of slow-release bezafibrate in elderly patients cannot be based merely on creatinine clearance. In general, it is recommended that bezafibrate retard is substituted by a reduced dose of normal-release bezafibrate below a creatinine clearance of 60 ml/min.

Administration, Oral↗
PubMed1988

High-performance liquid chromatographic method for the determination of alpha-amanitin and phalloidin in human plasma using the column-switching technique and its application in suspected cases of poisoning by the green species of amanita mushroom (Amanita phalloides).

A reversed-phase high-performance liquid chromatographic assay has been developed for the simultaneous determination of alpha-amanitin and phalloidin in human plasma. The procedure is based on the enrichment of the toxins on a pre-column, followed by the transfer of both compounds in a foreflush mode to the analytical column. alpha-Amanitin and phalloidin can be quantified reliably down to a minimum concentration of 10 ng/ml in plasma (relative standard deviation less than 10%). An alternative method is recommended for hepatic coma patients.

Agaricales↗
PubMed1988

Clearance of heterologous, homologous and damaged homologous erythrocytes by the isolated perfused rat liver.

Homologous and autologous rat erythrocytes, human erythrocytes as well as glutaraldehyde-treated and hemolysed homologous red blood cells suspended in an isotonic, buffered saline, free of immunoglobulins were perfused through the isolated rat liver. The mononuclear phagocyte system of the liver (mainly Kupffer cells) was able to recognize damaged rat and heterologous human erythrocytes and to sequester them by a direct membrane-erythrocyte mechanism. Hemoglobin and homologous and autologous rat erythrocytes were not sequestered or only to a minor extent. High sequestration rates are reflected by an increased energy demand with subsequent increase of the lactate-pyruvate and beta-hydroxybutyrate-acetoacetate-quotient.

Animals↗