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Biomedical subjects

D Pfeiffer

Publications and source records attributed to D Pfeiffer.

At least 163 records · Page 9Linked to original sources
PubMed1983

Evidence of decreased plasma substance P levels in human essential hypertension and influence of prazosin treatment.

Patients with essential hypertension (n = 45) had significantly lower substance P plasma levels (13.6 +/- 2.30 pg/ml) in comparison with a group of 24 normotensive subjects (45.4 +/- 7.18 pg/ml) analyzed by radioimmunoassay. Prazosin treatment for 2 weeks with 4.5 mg/day enhanced the substance P plasma level depending on its antihypertensive effect. Norepinephrine concentration in plasma was also elevated by prazosin. Dipeptidylpeptidase IV, dopamine-beta-hydroxylase and plasma renin activity were not changed significantly. The results indicate the participation of substance P in pathophysiological processes of human essential hypertension.

Adult↗
PubMed1983

[Arteriosclerotic aneurysm as an unexpected intraoperative finding].

Unexpected arteriosclerotic aneurysms were found in 11 patients during operation performed for other reasons. They were located in the abdominal part of the aorta (8 cases), in the popliteal artery (2 cases) and in the cranial mesenterial artery (1 case). Complications of these aneurysms such as rupture or peripheral embolization, led to surgical intervention in 5 patients.

Aged↗
PubMed1983

[Uric acid determination in dilute serum with an enzyme electrochemical and enzyme-free sensor].

The paper describes the development of electrochemical methods for analytical determination of uric acid basing on amperometric sensors: with an uricase enzyme electrode, termed "electrochemical-enzymatic" method; with an enzyme-free electrode by indication of the anodic oxidation of uric acid, termed "electrochemical" method. The comparison of analytical quality of both methods shows a sufficient specificity, precision, and accuracy. They show a good correlation with regard to the specific uricase-catalase reference method (UCM): yelectr./enz. = (0.943 xUCM + 19.8) mu mol/l; r = 0.9948 yelectr. = (0.964 xUCM + 6.31) mu mol/l; r = 0.9917 The analysis by the "electrochemical" method can be done with a higher frequency of samples per hour completely without need of enzyme. Both methods are principally suitable for an application in analytic biochemical laboratories.

Electrochemistry↗
PubMed1980

Glucose oxidase bienzyme electrodes for ATP, NAD+, starch and disaccharides.

Based on a glucose oxidase sensor for determination of glucose several glucoseoxidase bioenzyme electrodes have been developed. Enzymes producing glucose by hydrolysis of saccharides (glucamylase, invertase, cellulase) as well as glucose consuming systems (hexo-kinase, glucose dehydrogenase) have been coupled to glucose oxidase. The function of the bienzyme systems was demonstrated by concentration measurements (blood glucose, maltose, ATP, NAD+, starch) and enzyme activity measurements (alpha-amylase, ATPase, lactate dehydrogenase).

Adenosine Triphosphate↗
PubMed1980

[Glucose determination in diluted whole blood using an enzyme electrode].

The construction and operation of a measuring device containing an enzyme electrode is described. Glucose oxidase is enclosed in an acrylamide film by means of photopolymerization. The maximal increase of the anodic current of the H2O2 being formed in the enzyme reaction serves as measuring signal. The device gives for diluted serum and blood correlation coefficients above 0,99 according to the methods given in the German Pharmacopeia 7. The measuring time for each specimen is roughly 90 s, the serial variation coefficient 2%.

Blood Glucose↗
PubMed1980

The fatty acid pattern of serum triglycerides and FFA in patients with essential hypertension of different stages, athletes, and normal subjects.

The fatty acid pattern of serum triglycerides and FFA in normal untrained subjects, normotensive athletes, patients with labile and stable essential hypertension as well as in hypertensives with overweight and mild hypertriglyceridemia has been evaluated by gas liquid chromatography. The most striking differences revealed the linoleic acid in triglycerides being increased in athletes and in patients with labile hypertension in comparison with normotensive untrained controls and patients with stable hypertension. On the basis of these data an enhanced need of polyunsaturated fatty acids corresponding to probands with high physical activity has been assumed in patients with an early stage of essential hypertension. The differences of arachidonic acid were not so distinct. The results can be relevant with regard to the pathogenetic role of prostaglandin precursors in the development and course of essential hypertension and atherosclerosis.

Adult↗