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Biomedical subjects

D Person

Publications and source records attributed to D Person.

4 recordsLinked to original sources
PubMed1994

A simplified phenytoin regimen for preeclampsia.

The objective of this study was to assess the feasibility of giving phenytoin to a group of mild preeclamptic women in a universal dosing scheme comparable to that typical of magnesium sulfate administration. Serum phenytoin levels were measured at regular intervals for 32 hours following a 1 g intravenous loading dose in 14 patients. A second group of 14 women received 500 mg orally to supplement the 1 g initial dose and had serum levels similarly measured. The resultant serum levels are described, and the effect of maternal weight analyzed. The average serum phenytoin level in the first 14 women given the 1 g loading dose fell to 10 micrograms/mL approximately 12 hours after treatment. Serum levels plateaued above this threshold in the 14 women given 500 mg of additional medication orally 10 hours after treatment initiation and were maintained for an additional 14 hours before decline was observed. The serum levels resulting from the initial 1 g loading dose were analyzed 8 hours after treatment initiation in the entire group of 28 women according to body weight, and a clinically significant effect of weight on serum level was observed only at the extremes of weight. We conclude that a universal dosing scheme comparable to that typically used for magnesium sulfate is feasible for phenytoin administration to preeclamptic women.

Female↗
PubMed1987

Aging and memory.

Although some age-related decline in memory probably occurs, most memory changes that result from normal aging are not as extensive within individuals or as representative within the population as previously had been believed (Zarit et al., 1981). Still, when older adults become aware of memory problems, they typically become quite alarmed (see Poon et al., 1980). One reason for this alarm is that memory loss has been found to be a reliable early sign of organic brain disease. Despite the sadness and severity of problems experienced by these patients and their families, the actual incidence of organic brain disease in older adults remains quite low. Unfortunately, it is possible that older adults' concern about less significant memory loss may compound or magnify problems that do exist. Therefore, when working with relatively healthy older adults, it is important first to consider possible transitory, nonmemory factors that could be contributing to memory problems and then to provide the clients with some perspective on their memory failures.

Aged↗
PubMed1985

The nature of arthritis pain.

A modified version of the McGill Pain Questionnaire in visual analogue format was used to evaluate the sensory, affective and evaluative intensities of pain experienced by 40 patients with rheumatoid arthritis and 20 patients with degenerative arthritis. The affective component of the pain was found to be more intense than the sensory component in all patients indicating the importance of emotional factors in the pain experience. The sensory aspects of the pain were more complex than the affective ones reflecting the varied sources and combinations of somatic pathology. There were no significant differences found in the overall pain experience between rheumatoid and degenerative arthritis. No differences were noted in the evaluative category of pain. Overall pain intensity increased with disease duration in both rheumatoid and degenerative arthritis. The relationship of affective and sensory components of the pain experience did not alter with duration of disease.

Aged↗