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Biomedical subjects

D Peleg

Publications and source records attributed to D Peleg.

At least 91 records · Page 5Linked to original sources
PubMed1986

Pregnancy complicated by diabetic nephropathy.

Diabetes mellitus is a high risk complication of pregnancy and this is particularly true whenever long standing diabetes is complicated by diabetic nephropathy. Five cases are reported of diabetic pregnancy complicated by nephropathy. Four women delivered healthy babies, and one patient aborted spontaneously in the 9th week of gestation. It is suggested that first and foremost in complicated diabetic pregnancy strict normoglycemia should be adhered to prior and all through pregnancy. Our findings based on these cases also suggest that: Pregnancy does not adversely affect the renal status of a diabetic woman or vice versa. Creatinine clearance is not worsened by the course of pregnancy in the majority of these patients and proteinuria per se does not add additional risks to pregnancy or outcome. Hypertension is a separate risk factor affecting the pregnancy despite normoglycemia. Motivation of these patients to maintain normoglycemia as well as bed rest for prolonged periods, intensive use of fetal monitoring, evaluation of fetal lung maturity and improved neonatal care may contribute to improved perinatal outcome.

Adult↗
PubMed1986

Lymphoid hypophysitis associated with sudden maternal death: report of a case review of the literature.

A case of lymphoid hypophysitis in a woman who died during labor is presented. From a review of the 14 previously reported cases it is apparent that this is a specific disease entity, that it involves only woman, especially in association with pregnancy, and that it may have a fatal outcome. The clinical manifestations are either related to hypopituitarism, or those of a space occupying lesion. Attention drawn to the possible occurrence of the disease may result in earlier recognition of the disease and a better outcome of this potentially fatal disease.

Adult↗
PubMed1985

P31, a mammalian housekeeping protein encoded by a multigene family containing a high proportion of pseudogenes.

The primary structure of P31, a 13.300 kDa mammalian 'housekeeping' protein, was deduced from the nucleotide sequence of a rat recombinant cDNA clone. The P31 mRNA has 950 nucleotides and codes for a protein of 121 amino acids. This mRNA is present in several mouse tissues and in other mammals. Nuclei of rapidly growing cells contain mature P31 mRNA and a distinctive set of larger transcripts. P31 is encoded by a multigene family. Five members of the family were isolated from a mouse genomic library and restriction mapping and S1 nuclease analysis of four of them (P31-4, P31-12, P31-13 and P31-14) suggest that they are processed genes. The very low homology of the fifth (P31-8) with respect to the corresponding cDNA sequence indicates that it is a pseudogene. Although the features of the mRNA and the genes encoding P31 exhibit extensive similarity with those of ribosomal proteins, neither the identity nor the biological function of the protein has yet been determined.

Amino Acid Sequence↗
PubMed1985

Tocolytic and hemodynamic effects of nifedipine in the ewe.

The ability of the calcium antagonist nifedipine to inhibit uterine contractions during labor and in the postpartum period was measured in the ewe. The hemodynamic effects of tocolytic doses of this drug were measured and compared with the hemodynamic effects of equivalent doses of ritodrine. Intravenous nifedipine was found to be a potent tocolytic agent that completely inhibited uterine activity even in advanced labor when administered at infusion rates that resulted in only mild hemodynamic effects. At tocolytically similar infusion rates nifedipine produced significantly less increase in maternal heart rate than did ritodrine.

Animals↗
PubMed1985

Fetal hydrothorax and bilateral pulmonary hypoplasia. Ultrasonic diagnosis.

Bilateral pulmonary hypoplasia associated with hydrothorax is an unexplained entity. The purpose of this study was to evaluate an ultrasonic diagnostic approach towards this problem. Antenatal screening of pregnancies at risk for fetal hydrothorax, early detection of suspected hypoplasia and active management might afford the fetus adequate pulmonary function to support extra-uterine life.

Adult↗
PubMed1984

Predominance of L-dopa in fetal plasma and the amniotic fluid during late gestation in the rat.

The purpose of this study was to reevaluate catecholamine distribution in fetal and maternal compartments during late gestation in the rat. Fetal and maternal plasma and amniotic fluid were collected from anesthetized rats on consecutive days from day 17 to day 22, the day of parturition. The fluid was analyzed for dihydroxyphenylalanine (L-dopa), dopamine, norepinephrine, and epinephrine by radioenzymatic assays. Amniotic fluid volume was determined by a direct weighing method. L-Dopa concentrations constituted approximately 50% of total fetal plasma catecholamines and were significantly higher in fetal than in maternal circulation. Dopamine concentrations in fetal plasma were tenfold lower than those of L-dopa but were also significantly higher in fetal than in maternal plasma; norepinephrine levels were similar in both. Maternal plasma epinephrine levels remained relatively constant, whereas fetal epinephrine levels increased fiftyfold from day 17 to day 22. L-Dopa concentrations in the amniotic fluid were tenfold higher than those of dopamine, and the concentrations of both increased markedly during the last 2 days of gestation. However, this apparent rise could be attributed to the concomitant fivefold reduction in the amniotic fluid volume observed at this time. It is concluded that L-dopa is the predominant catecholamine in both the fetal plasma and the amniotic fluid during late gestation in the rat. At the present time, neither the source nor the possible physiologic functions of L-dopa during fetal life are known.

Amniotic Fluid↗
PubMed1983

Holoacardius: radiologic investigation.

A case of holoacardius is presented from a monozygotic twin pregnancy of 20 weeks, in which the other twin was normal. The classification is reviewed. While the physiology and anatomy of these malformations are known, the etiology remains obscure. Theories of etiology may be divided in two groups: that the primary deficiency is a failure of the parts to develop; and the belief that the acardius is due to an abnormal vascular communication with secondary atrophy of the formed parts. The abnormal twin in the case studied was diagnosed by ultrasound prenatally and investigated radiologically post-mortem.

Abnormalities, Severe Teratoid↗
PubMed1983

FHR patterns in Potter's Syndrome.

The antenatal diagnosis of POTTER's Syndrome (bilateral renal agenesis) is important in order to avoid delivery by cesarean section of newborns with congenital anomalies incompatible with life. In seven cases of this syndrome delivered at the Hasharon Hospital, a similar FHR pattern was retrospectively observed in pregnancy and labor suggesting that electronic fetal monitoring (EFM) may possibly contribute to the diagnosis of this condition in utero. Nevertheless, it must be emphasized, that similar cardiotocographic alterations may result from umbilical cord and/or placental compression in the presence of severe oligohydramnios. The latter may, concurrent with POTTER's Syndrome, predispose to changes in intraamniotic pressure transmitted to fetal autonomic centers. Thus, these variations in FHR pattern may be of value only if the presence of other signs of POTTER's Syndrome is confirmed by a reliable ultrasound examination. Further observations of antenatal FHR patterns in a large number of cases of this syndrome may establish their value in the antenatal diagnosis of POTTER's Syndrome.

Female↗
PubMed1980

Fetal heart rate acceleration in response to light stimulation as a clinical measure of fetal well-being. A preliminary report.

Numerous tests have been proposed for the assessment of fetal condition during the antenatal period. This preliminary report suggests the possibility of exposing the fetus-in-utero to alternating light during amnioscopy, with simultaneous registration of the fetal heart rate. This simple, non-invasive, inexpensive test, which may be evaluated instantaneously, shows a good correlation to the condition of the fetus and newborn, as expressed by the O.C.T. and the APGAR score respectively. The advantage of this test is that it is independent of the existence of fetal movements, as well as of the arousal state of the fetus.

Female↗
PubMed1980

Massive extraperitioneal bleeding -- a rare complication of amniocentesis.

Amniocentesis is a widely used procedure, infrequently associated with complications. A patient in the 16th week of pregnancy is described, in whom amniocentesis for the purpose of genetic counselling was complicated by severe extraperitoneal bleeding into the abdominal wall, necessitating the surgical evacuation of a large hematoma. The bleeding most probably resulted from the accidental puncture of the right deep epigastric artery.

Abdominal Muscles↗
PubMed1979

The assessment of lung maturity in infants of diabetic mothers, by means of L/S ratio determination in tracheo-pharyngeal aspirate.

The respiratory distress syndrome is more common in the newborns of diabetic mothers. The comparatively high rate of incidence of this syndrome depends neither on gestational age nor delivery route. In view of these facts, the evaluation of fetal lung maturation of diabetic mothers seems to be of the utmost importance. The methods usually employed for the determination of fetal lung maturation are of limited value, because occasionally L/S ratio values, which usually indicate fetal lung maturation, may fall to below critical levels. It is, therefore, extremely important to assess lung maturity in the newborn of a diabetic mother at the time of delivery. In 15 pregnancies complicated by diabetes mellitus of all degrees of severity (A-D), according to the classification of P. WHITE, L/S ratio in amniotic fluid prior to delivery was determined. L/S ratio was determined in tracheopharyngeal aspirate, as well, soon after delivery. In all cases the foam stability test was done in the amniotic fluid before delivery and, when there was a sufficient quantity, also in the tracheo-pharyngeal aspirate. According to the foam test and L/S ratio in the amniotic fluid, all fetuses supposedly had normally matured lungs. Nevertheless, according to these two tests in the tracheopharyngeal aspirate, results indicate lack of full lung maturity in four cases. In fact, all these four newborns developed the respiratory distress syndrome. This test appears to be reliable, simple and non-invasive, and is therefore recommended in babies with diabetes of all degrees of severity, and in all gestational ages.

Diabetes Complications↗
PubMed1979

Arteriography and chemotherapy in localized trophoblastic disease, by means of local- (pelvic-) intraarterial infusion.

In spite of considerable progress in systemic chemotherapy in malignant throphoblastic disease, there remains a small group of patients who fail to respond to this type of therapy. Here the trophoblastic process may be localized by means of an arteriography, and treated by a local, intraarterial infusion of cytotoxic compounds in high concentration. The latter makes possible the treatment of processes localized in essential organs which are hard to remove, as well as in young women wishing to preserve their reproductive capacity. Our experiences is limited to one case of a young woman with chorioadenoma destruens in the uterus, resistant to systemic chemotherapy, yet successfully treated with pelvic, intraarterial infusion of cytotoxics.

Adult↗
PubMed1979

Fetal heart patterns. A study of the anencephalic fetus.

The anencephalic fetus is an interesting model for the study of the fetal heart rate (FHR). Such a fetus could serve as a model for the examination of the effect of "intracranial" pressure on the FHR, because its central nervous system (CNS) is directly exposed to intraamniotic pressure changes. The FHR was monitored in 10 anencephalic fetuses of normal, uncomplicated pregnancies and of gestational age between 35 and 42 weeks. Silent-pattern heart rate was observed in 6 of the monitored anencephalic fetuses. No other consistent heart rate pattern was obtained. A relatively high incidence of extreme early decelerations may be attributed to the exposure of the fetal CNS to direct pressure.

Anencephaly↗
PubMed1978

Fetal deglutition: a study of the anencephalic fetus.

The deglutition of amniotic fluid in utero by the anencephalic fetus is a controversial subject. We have studied 7 anencephalic pregnancies complicated by hydramnion in their third trimester of gestation. Fetographies revealed that 6 out of 7 anencephalic monsters showed signs of swallowing of the contrast material after only 3 h. The baby which was born dead could not swallow at all. The fact that the babies studied swallowed amniotic fluid shortly after injection of contrast media seems to confirm the opinion that fetal deglutition contributes only little to the mechanism of amniotic fluid volume regulation.

Adult↗