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Biomedical subjects

D Pearson

Publications and source records attributed to D Pearson.

At least 217 records · Page 12Linked to original sources
PubMed1977

Payment patterns.

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Accounting↗
PubMed1977

A description of Walter Reed Army Medical Center's in-patient psychiatric service population 1973 to 1975.

A three-year evaluation of demographic and diagnostic patterns in a large Army psychiatric in-patient facility is described. Active duty personnel accounted for 83.6 percent of patient episodes. No simple catchment area could be defined for this facility. Active duty patient episodes tended to be with younger, junior enlisted men whose sicknesses were most frequently diagnosed as schizophrenia. The diseases of blacks were diagnosed as paranoid schizophrenia more frequently than in whites. Latent schizophrenia or undifferentiated schizophrenia were diagnosed more frequently in whites than in blacks. The illnesses of active duty female military personnel were more frequently diagnosed as neurotic than as schizophrenic. Of the patient episodes during the three-year period, 12.1 percent were about dependents. They were usually the wives of older, senior enlisted men or senior officers and they stayed an average of 12 days in the hospital. On the other hand, 4.3 percent of the patient episodes were about retired personnel. They came from Walter Reed Army Medical Center (WRAMC) as did their dependents, and the most frequent diagnosis was alcoholism. Their median stay was 15 days. Subsequent studies will attempt to further clarify these initial findings.

Adolescent↗
PubMed1976

Growth hormone deficiency in children with brain tumors.

Nine children with brain tumors are described who have received various combinations of treatment, including surgery, radiotherapy, and chemotherapy. Many of the children were noted to be of short stature. Endocrine assessment was carried out from 2 to 10 years after treatment. The combined results of insulin tolerance and Bovril stimulation tests show an impaired growth hormone response in six of the nine children. Bone age is retarded in all cases, and the present height is below the 10th percentile in five of the six. The cause of this growth hormone deficiency is obscure, but further studies are in progress.

Adolescent↗
PubMed1976

Residual disabilities in children treated for intracranial space-occupying lesions.

A retrospective study of 30 long-term survivors of cranial or craniospinal irradiation for intracranial space-occupying lesions has demonstrated physical and mental handicaps in the majority. This is most severe in those cases treated before the age of 11 years, and is not confined to those children having craniospinal or whole-brain irradiation. The mental handicap also appears to be progressive, but cannot be easily examined in this retrospective study.

Adolescent↗
PubMed1976

Ovarian failure following abdominal irradiation in childhood.

Ovarian function was studied in 18 female patients treated for abdominal tumours during childhood. All received abdominal radiotherapy as part of their treatment and were studied between 1 and 26 years after irradiation. The serum gonadotrophins and oestradiol levels were consistent with ovarian failure in each case but there was a disproportionate elevation in serum follicle stimulating hormone (FSH) when compared to serum luteinizing hormone (LH) in 16. In 2 patients, the radiotherapeutic field extended downwards only as far as the sacral promontory. However, these 2 girls show similar evidence of ovarian failure to that in the other 16.

Abdominal Neoplasms↗
PubMed1976

The effect of varying doses of cerebral irradiation on growth hormone production in childhood.

The radiation dose, delivered to the hypothalamic-pituitary region, has been calculated in thirty-nine children irradiated for brain tumours and in seventeen children who had received prophylactic cranial irradiation for acute leukaemia. All subjects had an insulin tolerance test at least 2 years after their radiotherapy. There is a significant inverse correlation between radiation dose and peak GH response. Thirty-seven of the fifty-six patients showed an impaired GH response and thirty-six of these received more than 2900 rads. Only five patients who received such a dose showed normal GH responses and four of these were aged over 13 years when treated. In conclusion, cerebral irradiation is a potent cause of GH deficiency in children.

Adolescent↗
PubMed1976

Growth hormone deficiency after treatment of acute leukaemia in children.

Growth hormone (GH) secretion was studied in 15 children at various times after treatment for acute lymphatic leukaemia. Impaired GH responses both to hypoglycaemia and to Bovril were found in 4 children. 13 of the children had been given prophylactic cranial irradiation of either 2500 rads in 10 fractions or 2400 rads in 20 fractions. The reduction in GH responses in those given the former dose was highly significant compared with the reduction in those given the latter dose. However, other differences between the two groups included the length of time since cranial irradiation and the chemotherapy used. The main cause of the GH deficiency is not yet clear, but we conclude that it may occur in children treated successfully for acute lymphatic leukaemia.

Antineoplastic Agents↗
PubMed1976

Medulloblastoma of the cerebellum.

On the base of 77 medulloblastomas of the cerebellum, it is a point out the actual management of children with medulloblastoma which can be summed up as a combination of surgery to relieve pressure and remove as much of the tumor as possible, para-operative vincristine, radical treatment of the whole C.N.S. by radiotherapy followed by maintenance chemotherapy of B.C.N.U. and vincristine.

Adolescent↗
PubMed1976

Epidural hematoma after minor oral trauma.

A case report was presented in which a 15-year-old boy was beaten about the head with a baseball bat. Intraoral trauma and facial lacerations were repaired. Since results of the neurological examination were within normal limits, the patient was discharged. The next day, the patient became lethargic; however, the patient's mother did not bring the patient back to the hospital until the routine postoperative visit. At that time, the patient had right hemiparesis, was unable to speak, and was clearly obtunded. A carotid angiogram disclosed a left venous epidural hematoma in the parietal area. A craniotomy was performed with good results. The importance of follow-up neurologic examinations in cases of trauma to the face and head is stressed.

Adolescent↗
PubMed1976

Alcoholism: averaged visual evoked response amplitude-intensity slope and symmetry in withdrawal.

Alcohol withdrawal has been characterized in terms of some EEG changes but seldom in terms of the averaged evoked response. Characteristics of the AER, such as amplitude, latency, and the least-squares slope of the AER amplitude as a function of stimulus intensity, have been found to change as a function of arousal and to separate some psychiatric groups. Seventeen alcoholics in withdrawal, 27 stabilized alcoholics, and 30 control volunteer subjects participated in an experiment to determine the changes in AER characteristics in withdrawal. Four stimulus intensities were presented to the subjects from a Grass PS 22 photostimulator with the flash sources 102 cm from the nasion. AER amplitude, the slope of the amplitude as a function of stimulus intensity, and bilateral symmetry scores were calculated for group comparison. Withdrawal and stabilized alcoholics were found to have significantly greater AER amplitudes at all intensity levels. Greater A-I slope from the right hemisphere and higher symmetry were found for withdrawal alcoholics than the other two groups.

Adult↗
PubMed1975

Pituitary function after treatment of intracranial tumours in children.

Pituitary-function tests have been done in twenty-seven patients at various times after treatment in childhood for intracranial tumours not directly involving the hypothalamic-pituitary region. Impaired growth hormone (G.H.) responses to hypoglycaemia and 'Bovril' were found in ten children. There seeems to be progressive impairment in G.H. production with time after treatment. During the first 3 months after neurosurgery no child was found to be G.H. deficient, but the peak G.H. response of this group seemed to be blunted when compared with a control group of children who had been treated for abdominal tumours. The rest of anterior-pituitary function in G.H.-deficient children seems quite normal except for a significantly greater basal thyroid-stimulating hormone (T.S.H.) level and T;S.H. response after thyrotrophin-releasing hormone. Two girls have developed secondary amenorrhoea, and one is G.H. deficient.

Adolescent↗