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Biomedical subjects

D Pal

Publications and source records attributed to D Pal.

At least 91 records · Page 5Linked to original sources
PubMed1983

Analysis of progesterone receptor in the quail oviduct. Correlation between plasmatic estradiol and cytoplasmic progesterone receptor concentrations.

Specific binding sites for [3H]-progesterone are found in the cytosol fraction of the oviduct of castrated, immature and developing quails. The optimal conditions to accurately measure the total cytoplasmic concentration of this progesterone receptor are described. The dissociation constant (KD) at 0 degrees C is 3.6 +/- 0.6 x 10(-9) M (mean +/- SE) for [3H]-P and the concentration of binding sites is 13.4 +/- 2 pmol/mg DNA in immature animals. This binding capacity is not altered even 2 weeks after ovariectomy. During sexual development, although the dissociation constant remains unchanged, the number of binding sites increases to 74.5 +/- 1.6 pmol/mg DNA just before the beginning of the laying cycle. The concentration of cytoplasmic P receptor is under the inductive influence of estradiol. In castrated quails, estradiol 17 beta (E2) perfusion through the portal vein at a rate below or equal to 2 ng/min for 24 hr does not increase plasmatic E2 concentration and consequently does not change [3H]-P binding sites concentration in the oviduct. While E2 perfusion rate exceeds the metabolizing capacity of the liver (6.8 ng/min), both plasmatic E2 level and oviductal P receptor concentration are increased. When E2 is perfused through the jugular vein, plasmatic E2 level increases with the dose of E2 but P receptor concentration only increases when E2 perfusion rate reaches to 2.0 ng/min for 24 h.

Animals↗
PubMed1982

Assessment of chemoprophylaxis in open-heart surgery patients.

Regular assay of antibiotics in the sera of patients may be helpful in open-heart surgery patients, neurosurgery patients, immunosuppressed individuals, patients on antineoplastic therapy, or other high-risk patient groups. It may be especially helpful in regulating their antibiotic dosages and in giving forewarning about impending bacterial infections. A method for simultaneous serum assay of two antibiotics belonging to the same penicillin group of drugs is described here. Such combined assay procedures are usually not undertaken, largely due to the technical difficulties involved. The procedures described here should prove helpful in monitoring antibiotic therapy in patients on combined Ampi-Clox regimen, whenever necessary.

Adult↗
PubMed1980

Effect of heating on the hardness of human bone.

Specimens of dry human bone wee subjected to gradual or sudden heating up to different temperatures. After heating they were cooled suddenly or gradually to room temperature. Their hardness was studied by the Vickers and ball indentation tests. The deformation produced was studied by interferometric and phase-contrast techniques. Heating caused the bone to become brittle without any considerable changes in the surface features. Gradual cooling induced surface hardening. Heating was not found to affect indentation-induced surface distortion.

Bone and Bones↗
PubMed1979

Micro-indentation hardness studies on human bones.

Bones from different portions of human skeleton are polished and cut to suitable sizes and then subjected to micro-indentation at various loads using Vicker's diamond pyramidal indenter. The Vicker's hardness number is found to differ slightly from portion to portion of the skeleton. Interferometric studies of the indentation reveal that the applied stress of indentation causes a 'pile-up' of material near the corners of the pyramidal indents.

Bone and Bones↗
PubMed1977

Histochemistry of the utero-vaginal junction with special reference to the sperm-host glands in the oviduct of the domestic duck.

The "utero-vaginal junction" that connects the uterus and vagina of duck oviduct differs histologically and histochemically from the adjacent zones. The region is characterised by low, somewhat longitudinally arranged mucosal folds, lined by tall columner cilliated cells with apical nuclei alternating with mucous secreting goblet cells containing basal nuclei. Within the propria of the mucosa there are numerous tubular glands--the sperm host glands--which are responsible for sperm storage after copulation. The goblet cells of the utero-vaginal junction contain an admixture of neutral, sulfated and nonsulfated acid mucopolysaccharides, while the sperm host glands are devoid of any mucopolysaccharide and secrete complex lipoidal materials and exhibit intense acid phosphatase activity. The functional significance of the secretory materials of the sperm host glands have been discussed in the light of sperm release mechanism.

Acid Phosphatase↗
PubMed1976

Post ovulatory follicles of the domestic duck.

Histogenesis of the post-ovulatory follicles in relation to the regression process has been studied in the Indian domestic duck. The activities of the alkaline phosphatase, acid phosphatase, sudan black-B and periodic acid Schiff reaction have been demonstrated histochemically. No lutein cells comparable to the mammalian corpus luteum are found. The hypertrophy or proliferation of granulosa cells are not observed in this bird. The functional significance of different histochemically demonstrable material and steroidogenesis in the avian post-ovulatory follicles have been briefly discussed.

Acid Phosphatase↗
PubMed1975

Possible antineoplastic agents I.

A few thalidomide and glutarimide derivatives were synthesized. Several compounds possessed significant antineoplastic activity against Ehrlich ascites carcinoma in Swiss albino mice.

Animals↗