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Biomedical subjects

D Paar

Publications and source records attributed to D Paar.

At least 55 records · Page 3Linked to original sources
PubMed1985

Intraperitoneal heparin in CAPD.

In six patients on CAPD (continuous ambulatory peritoneal dialysis) the systemic effects of intraperitoneally administered heparin (5000 U) were investigated. Using a modification of a plasma heparin determination serial measurements of heparin concentration in dialysate were performed. During a dwell time of 4 hours the intraperitoneal heparin level decreased by 1825 +/- 253 U (mean +/- S.E.M.). Simultaneously the plasma anti-IIa-activity of heparin after 4 hours and the anti-Xa-activity after 2 and 4 hours increased significantly (p less than or equal to 0.05). The maximum of heparin activity after 4 hours was 0.015 +/- 0.001 U/ml and 0.024 +/- 0.003 U/ml, respectively (mean +/- S.E.M.). An increase of activated partial thromboplastin time was not observed. The small increase of heparin activity in plasma is in contrast to reported activities measured after subcutaneous application of this dose of heparin. In CAPD the effect of heparin is largely restricted to the peritoneal cavity.

Female↗
PubMed1984

Pharmacokinetic and pharmacodynamic interactions between phenprocoumon and atenolol or metoprolol.

Pharmacological interactions in both directions between phenprocoumon and atenolol and metoprolol were investigated using a crossover trial. Co-administration of phenprocoumon did not significantly affect Cmax, tmax, t1/2,22, AUC for atenolol or metoprolol. Co-administration of metoprolol, but not atenolol, increased mean plasma phenprocoumon concentrations 4 and 6 h after dosing and was caused by a decrease in the apparent volume of distribution. This increase in plasma phenprocoumon was not associated with an increase in prothrombin time or in the total area under the concentration-time curve. Although the transient increase of phenprocoumon plasma levels caused by metoprolol may be of little clinical significance after a single dose of phenprocoumon, a more important alteration in phenprocoumon disposition and effect should be considered in individual patients on long-term therapy.

4-Hydroxycoumarins↗
PubMed1982

[Ultrasound controlled puncture of renal cysts: biochemical and radiological findings (author's transl)].

Ultrasonographically-guided renal cyst puncture was done in 128 patients on outpatient basis. Cortical renal cysts were seen in both male and female patients in an equal ratio. Mean age was 59.6 years. Complication rate of percutaneous puncture was low. Only twice transient haematuria was observed, needing no treatment. Aspirated fluids were examined cytologically and biochemically. None of the aspirated specimens showed malignant cells. Biochemically lactate dehydrogenase activity and concentrations of total protein, cholesterol, triglycerides, potassium and creatinine were determined. Potassium and creatinine determination were found to be valuable in distinguishing between cystic-like lesions containing secondary urine (like caliceal cysts, hydronephrosis, urinoma) and those containing primary urine (like cortical renal cysts). Thus measurement of potassium and creatinine in aspirated fluids may be helpful in determining the need for open exploratory surgery. In cases where cystic lesions produce urographically visible defects of the pelvic system, a dilatation of this area after evacuation of the cyst can be demonstrated via intravenous urography.

Adolescent↗
PubMed1982

Comparison of the morphological alteration and disintegration test (MADT) and the chimpanzee infectivity test for determination of hepatitis B virucidal activity of chemical disinfectants.

The morphological alteration and disintegration test (MADT) as a key indicator for Hepatitis B Virus (HBV) inactivation was compared with the chimpanzee infectivity test using three suspensions of HBV differing in the degree of inactivation as judged by electronmicroscopic studies. The results of the MADT and the chimpanzee studies correlated well. Thus, the MADT, evidently, can replace the laborious, costly and time-consuming animal studies for the evaluation of chemical disinfectants for hepatovirucidal activity.

Aldehydes↗
PubMed1980

Spectrometric determination of urokinase in urine after gel filtration, using the chromogenic substrate S-2444.

Using the chromogenic substrate S-2444, the spectrometric determination of urokinase (EC 3.4.21.31) in urine subjected to gel filtration was evaluated. Pure urokinase solutions were used to standardize analytical conditions. A low molecular mass (relative molecular mass < 5000) heat resistant (60 min, 97 degrees C) activity could be removed from urine by gel filtration (Sephadex G 25 Medium). In the analysis of the high molecular mass fraction (relative molecular mass > 5000) of urine, amidolysis remained linear during a period of 3 hours. The relation between enzyme activity and substrate turnover was linear in the range from 0.05-12 U/l. The coefficients of variation for within-run precision ranged from 1.4-3.8%. The analytical recovery was 98-104%. Average urokinase excretion in morning urines (collection period 1-3 hours) of 10 healthy males and 10 healthy females was respectively 0.82 and 0.68 U/g creatinine.

Chromatography, Gel↗
PubMed1980

[Determination of progesterone in urine by a competitive protein binding method (author's transl)].

A new method, based on the principle of competitive protein binding, is described for the determination of progesterone in urine. The sensitivity of the assay for progesterone is 0.24 micrograms/l urine. The within-assay precision, as determined by the coefficient of variation, varies between 4 and 10%, the between assay precision between 9.2 and 17%. The recovery of progesterone is 104.3%. The average urinary progesterone excretion in normal men is 0.12 +/- 0.10 micrograms/g creatinine. In the follicular phase of 17 normal women the urinary progesterone excretion is 1.4 +/- 1.1 micrograms/g creatinine, in the luteal phase 7.7 +/- 4.6 micrograms/g creatinine. In normal pregnancy the urinary progesterone excretion rises significantly (y = -11.1 +/- 1.1 x, r = 0.66, n = 175, p < 0.001) from 1.5 to 25.7 micrograms/g creatinine.

Creatinine↗
PubMed1975

[Immuno-coagulopathies and their dangers in dental-surgical interventions].

It is reported on three patients with an immunocoagulopathy, the diagnosis of which was established on the basis of immunological coagulation studies. These patients were submitted to oral surgery. In connection with the case histories, it is reported on pathogenesis, diagnostics, and special therapeutical requirements in cases of hemorrhagic diathesis with a circulating anticoagulant antibody.

Adult↗