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Biomedical subjects

D P Rosenberg

Publications and source records attributed to D P Rosenberg.

18 recordsLinked to original sources
PubMed1996

Late complications of immune deviation therapy in a nonhuman primate.

The administration of antigens in soluble form can induce antigen-specific immune tolerance and suppress experimental autoimmune diseases. In a marmoset model of multiple sclerosis induced by myelin oligodendrocyte glycoprotein (MOG), marmosets tolerized to MOG were protected against acute disease, but after tolerization treatment a lethal demyelinating disorder emerged. In these animals, MOG-specific T cell proliferative responses were transiently suppressed, cytokine production was shifted from a T helper type 1 (TH1) to a TH2 pattern, and titers of autoantibodies to MOG were enhanced. Thus, immune deviation can increase concentrations of pathogenic autoantibodies and in some circumstances exacerbate autoimmune disease.

Animals↗
PubMed1990

Cynomolgus monkeys.

In the report "Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa" by L. Waxman et al. (4 May, p. 593), the second sentence of the caption of figure 2 was printed incorrectly. It should have read, "Determination of the Intrinsic K(i) was done by fitting the observed data (*) with nonlinear regression analysis to the ratio of inhibited velocity (v(i)) to uninhibited velocity (V(o)) described by the equation V(i)/V(o) = [E(t) - I(t) K(*)(i)] + [(I(t) + K(*)(i) - E(t))(2) + 4K(i)E(t)](1/2)/2E(t) derived by Morrison for tight-binding inhibition (7) (solid line), where E(t) and I(t) are the total amount of enzyme and inhibitor, respectively, included in the assay."

Animals↗
PubMed1983

Hyperosmolar non-ketotic diabetic coma in the nonhuman primate: a first report.

Diabetes mellitus was diagnosed in an aged bonnet macaque (Macaca radiata). Six months later the monkey was found comatose. Laboratory findings of extreme hyperglycemia, hyperosmolality, and glycosuria without ketonuria were consistent with a diagnosis of hyperosmolar, non-ketotic diabetic coma (NKC). Further laboratory studies disclosed very low levels of immunoreactive insulin and depressed free fatty acid values. Growth hormone and cortisol levels were within normal limits.

Animals↗
PubMed1983

Arteriovenous malformation in a rhesus monkey (Macaca mulatta).

A developmental arteriovenous malformation of the right arm was recognized in a 1-year-old rhesus monkey. The diagnosis was based on physical findings, ultrasound, and angiography. Treatment consisting of therapeutic transcatheter embolization using polyvinyl alcohol was performed with partial success. Necropsy revealed a lesion that was limited to the skin and subcutis. An abnormal vascular pattern was present leading to and within the lesion.

Animals↗
PubMed1982

Response of thyroxine and triiodothyronine to thyroid-stimulating hormone in adult female baboons (Papio cynocephalus).

The thyroxine (T4) and triiodothyronine (T3) response of the female baboon to injection of exogenous thyroid stimulating hormone was studied. This response established reference values for baseline and post-stimulation serum levels of T4 and T3. The reference values for T4 and T3 by radioimmunoassay were 9.9 +/- 2.2 micrograms/dl and 121 +/- 18 ng/dl, respectively. The T4 response to thyroid-stimulating hormone reached its peak level of 22.7 +/- 1.8 micrograms/dl at 12 +/- 2.5 hours. The corresponding peak response for the T3 was 351 +/- 61 ng/dl which occurred at 8.0 +/- 2.5 hours. The T3 response was more rapid and reached its peak earlier than T4.

Animals↗
PubMed1980

Yersinia pseudotuberculosis infection in a group of Macaca fascicularis.

Diarrheal disease associated with abortions and stillbirths occurred in a group of 42 Macaca fascicularis. The group was composed of wild-caught adults and their colony-born offspring housed in a half-acre cage. Thirteen adult females and 1 infant male were affected. All 14 monkeys had diarrhea and all 9 pregnant females either aborted or had a stillbirth. Yersinia pseudotuberculosis was isolated from 7 animals. In addition, Y enterocolitica was isolated from 1 monkey and Shigella flexneri type IV was isolated from 5 monkeys. One adult female had a mixed infection of both Y pseudotuberculosis and S flexneri. Every pregnant monkey from which Y pseudotuberculosis was isolated aborted or had a stillbirth. Five animals died, and Y pseudotuberculosis was the only pathogen isolated from these 5 monkeys.

Abortion, Veterinary↗
PubMedDate not supplied

Extrahepatic biliary atresia in a rhesus monkey (Macaca mulatta).

Extrahepatic biliary atresia was observed in a 6-week-old female rhesus monkey. Jaundice and conjugated hyperbilirubinemia were detected at the age of 6 days and persisted throughout life. At 6 weeks of age, the diagnosis of extrahepatic biliary atresia was established at exploratory laparotomy, and bile duct remnants were biopsied. Histological examination of these specimens showed inflammatory and fibrosing lesions similar to those observed in humans with extrahepatic biliary atresia. Because of serologic evidence of Reovirus 3 infection in human patients with extrahepatic biliary atresia, serum of the affected monkey was tested for antibodies to this virus. Three sequential serum samples obtained during the course of illness showed persistently high Reovirus 3 titers which are consistent with but do not prove concurrent Reovirus 3 infection. This report represents the first documented case of spontaneous extrahepatic biliary atresia in a nonhuman primate and suggests that this species may be suitable for further investigation of the pathogenesis of this disease.

Animals↗