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Biomedical subjects

D P Roberts

Publications and source records attributed to D P Roberts.

23 records · Page 2Linked to original sources
PubMed1972

Treatment of gonorrhea with spectinomycin hydrochloride: comparison with standard penicillin schedules.

Spectinomycin hydrochloride, a new parenteral antibiotic prepared from Streptomyces spectabilis, was compared with standard U.S. Public Health Service-recommended dosages of aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea in 353 men and 314 women. Of the 314 women, 130 had a pretreatment positive rectal culture. All diagnoses were proven by culture on Thayer-Martin selective medium. Minimal inhibitory concentrations of both drugs were determined. Single doses of 2 and 4 g of spectinomycin were compared with 2.4 million units of procaine penicillin in males and with both 2.4 and 4.8 million units of procaine penicillin in females. Both spectinomycin schedules, 2.4 million units of penicillin in males and 4.8 million units of penicillin in females, resulted in cure rates in excess of 90%. There were no failures at the rectal site only in those women with positive rectal cultures. There was no advantage to using the larger amount of spectinomycin in either sex.

Antibiotics, Antineoplastic↗
PubMedDate not supplied

A model for evaluating tissue donation seminars: implications for skin banks.

Educational seminars on tissue donation are costly in terms of time, effort, and resources, for both the planners and the participants. Although long-term outcomes from these projects cannot always be practically assessed, specific short-term conclusions can be drawn and degrees of success measured. An ideal evaluation technique needs to address issues such as identification of participant interests, levels of existing participant knowledge, and participant reaction to presented materials. Assessment in these areas allows for subsequent modifications intended to produce more effective and interesting seminars. Such an evaluation technique has been developed, and it is presented here in the context of its application to an educational seminar on the topic of organ and tissue procurement with special reference to skin banking.

Analysis of Variance↗
PubMedDate not supplied

Reduced bacteria on transplantable allograft skin after preparation with chlorhexidine gluconate, povidone-iodine, and isopropanol.

A comparison was made of the residual microbiologic contamination on transplantable allograft skin for burn wound coverage taken from cadaver donors prepared by two different protocols. One group was prepared with povidone-iodine, detergent, and 70% isopropanol; the other was prepared with these agents and 4% chlorhexidine gluconate (CG). The skin from each of the donor bodies was removed from independently prepared body areas. Without CG, 13.7% of donor body areas were contaminated; with CG, only 5.6% were contaminated. The number of gram-positive bacterial species isolated from skin after CG preparation was dramatically reduced. The gram-positive bacterial contamination rate dropped from 12.1% to 2.2% of donor body areas, a drop of 82%. With CG, 12 of the 15 contaminant species were eliminated; and we saw a general reduction in the total number of contaminated body areas, a specific and pronounced reduction in gram-positive bacteria, and an increase from 86.3% to 94.4% in the amount of skin obtained from donor cadavers that tested negative for bacterial contamination.

1-Propanol↗