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Biomedical subjects

D P Popa

Publications and source records attributed to D P Popa.

At least 19 recordsLinked to original sources
PubMed1998

[Phacotopic glaucoma].

Phacotopic glaucomas or hypertonias due to lens movements are not rarely in ophthalmology. They are often due to a traumatic pathology. They are seldom due to a congenital or acquired zonular disease. It is very important to recognize the pathogenic mechanism for a proper treatment: pupillary block and/or angular block or phacolytic glaucoma. Lens displacement is possible in three different places, that may lead to different causes of hypertonia, that need different treatments. Laser iridotomy, improvement of lens and vitreous surgery changed the prognosis of this diseases.

Glaucoma, Open-Angle↗
PubMed1998

[Genetic considerations in chronic simple glaucoma].

The study of a representative group of primary open-angle glaucoma patients from Eye Clinic, University Hospital, Bucharest, showed a hereditary transmission in 43.11% of cases. Isolated cases were in 56.88%. Genetic study of the affected families showed an autosomal dominant transmission of the disease in 58.33% of cases, an autosomal recessive in 38.88% of cases and in 2.77% of cases the study was unconvincing. Genetic prognosis elaborations in primary open-angle glaucoma and the calculation of the recurrence rate of the disease in offspring showed the following values: in primary open-angle glaucoma patients--autosomal dominant transmission--the recurrence risk of the disease was 1/2 (50%) in primary open-angle glaucoma patients--autosomal recessive transmission--the recurrence risk was 1/200 (0.5%) It is important to achieve a complete familial investigation for all primary open-angle glaucoma patients. On this basis is necessary to achieve and analyse the genealogical tree, to find out the kind of transmission of the disease, to detect the carriers of pathological gene (the heterozygotes), to calculate the recurrence risk of the disease in offspring, for an efficient prophylaxis of the disease.

Adult↗
PubMed1998

[The efficacy of Cairns trabeculectomy in open-angle glaucoma].

The authors report the conclusions of their analysis of 308 operated eyes for primary open-angle glaucoma with Cairns trabeculectomy procedure. The analysed period is 1991-1995--and the patients have been operated in the Ophthalmology Clinic of the University Hospital of Bucharest. The work contains: 1) General epidemiologic characters: number of eyes, number of patients, sex, age. 2) The analysis of the surgical intervention's efficiency by the following parametres (TIO, visual acuity, field loss, fundus oculi changes) after 6 months, 12 months, 24 months ... to 5 years. 3) The repartition of the cases clinical forms of glaucoma: primary glaucoma, pigmentary glaucoma, myopic glaucoma > 6D, exfoliative glaucoma, glaucoma with normal pressure. 4) The efficiency of the trabeculectomy depending on the moment of the surgical intervention: first stadium, second stadium, advanced stadium. 5) The analysis of the risk factors: familial antecedents of glaucoma, hypertension, hypercholesterolemia, thrombosis of the central retinal vein, myopia > 6D. 6) The cataractogen effect of the trabeculectomy.

Aged↗
PubMedDate not supplied

Oxidative damage following cerebral ischemia depends on reperfusion - a biochemical study in rat.

The extent of brain injury during reperfusion appears to depend on the experimental pattern of ischemia/reperfusion. The goals of this study were: first, to identify the rate of free radicals generation and the antioxidant activity during ischemia and reperfusion by means of biochemical measurement of lipid peroxidation (LPO) and both enzymatic (superoxide dismutase - SOD, catalase - CAT, glutathione peroxidase - GPx) and non-enzymatic antioxidants activity (glutathione - GSH); and second, to try to find out how the pattern of reperfusion may influence the balance between free radical production and clearance. Wistar male rats were subject of four-vessel occlusion model (Pulsinelly & Brierley) cerebral blood flow being controlled by means of two atraumatic arterial microclamps placed on carotid arteries. The level of free radicals and the antioxidant activity were measured in ischemic rat brain tissue homogenate using spectrophotometrical techniques. All groups subjected to ischemia shown an increase of LPO and a reduction of the activity of enzymatic antioxidative systems (CAT, GPx, SOD) and non-enzymatic systems (GSH). For both groups subjected to ischemia and reperfusion, results shown an important increase of LPO but less significant than the levels found in the group with ischemia only. Statistically relevant differences (p<0.01) between continuous reperfusion and fragmented reperfusion were observed concerning the LPO, CAT, SOD and GSH levels, oxidative aggression during fragmented reperfusion being more important.

Animals↗
PubMedDate not supplied

The quantification of intrahemispheric EEG asymmetry in rat.

We have developed a simple model to quantify the intrahemispheric asymmetries (IA) present in the background EEG activity (BEA), of the adult rat during restrained wakefulness and anesthesia with Ether and chloral hydrate (CHL). We used a collectivity of 40 adult (140 g) male Wistar rats. The epidural EEG activity, was quantified within the 1-30 Hz band by six numerical parameters: root mean square (RMS), mean spectral frequency (MSF), spectral edge frequency at 95% (SEF95) and the relative spectral power (RSP) within the Theta (4.5-7.5 Hz), Alpha (7.5-12 Hz) and Beta (12.5-30 Hz) bands. A significant IA was considerate when simultaneously present in both hemispheres at p (t-Test) < 0.05. The only IA detected in the BEA of the awake restrained rat was the increased theta RSP over the fronto-parietal areas. The theta asymmetry was abolished under both types of anaesthesia. While ether had a global effect on BEA, CHL induced a strong IA reflected in all parameters except RMS and Theta RSP. The fronto-parietal areas seem to be relatively resistant to CHL. It is discussed that the intrahemispheric theta dominance over the frontoparietal areas should be regarded as an indicator of alertness in rats.

Anesthesia, General↗
PubMedDate not supplied

EEG differences between the opioid and adrenergic psyhoneuroendocrine rat types.

Our work is based on the hypothesis of the existence of an opioid psychoneuroendocrine type named "O" type (Cristea, 1993), opposed to the well known adrenergic "A" type described by Roseman and Friedman in 1980. In the present study we tested the differences between the background EEG activity (BEA) of the "O" and "A" rat types during restrained wakefulness and anesthesia with Ether and chloral hydrate (CHL). The differentiation of the psyhoneuroendocrine rat types was made using the level of painful sensitivity. 13 hypersensitive "A" and 14 hyposensitive "O" rats were selected from a 91 adult (140 g) male Wistar population using the distribution of the tail retraction time (TRT) during a tail-flick test. The epidural EEG activity, was quantified within the 1-30 Hz band by six numerical parameters: root mean square (RMS), mean spectral frequency (MSF), spectral edge frequency at 95% (SEF95) and the relative spectral power (RSP) within the Theta (4.5-7.5 Hz), Alpha (7.5-12 Hz) and Beta (12.5-30 Hz) bands. The quantification method used was able to detect statistically significant differences between the two psyhoneuroendocrine rat types during consciousness and light ether anesthesia but failed to show any differences during the deep CHL anesthesia. The particularities were shown to be topographically related with the fronto-parietal regions were "O" type showed a higher SEF95 during the awake restrained state. The pain sensitive "A" type showed a significant intrahemispheric theta RSP asymmetry both during consciousness and ether anesthesia while no such theta gradient could be shown for the "O" type. The differences between the "A" and "O" types are enhanced under light Ether anesthesia to which the "A" type is more resistant. The EEG complementarity between the "A" and "O" types is discussed.

Anesthesia, General↗