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Biomedical subjects

D P Moore

Publications and source records attributed to D P Moore.

At least 91 records · Page 5Linked to original sources
PubMed1982

Treatment of tardive dyskinesia with propranolol.

A double-blind, intensive case design was used to study the effect of propranolol on tardive dyskinesia. No short-term improvement was observed, but two of the four subjects responded to long-term propranolol use. Properties of propranolol other than acute beta blockade are suggested as possible mechanisms of action.

Adult↗
PubMed1981

Methylphenidate in depression and states of apathy.

Methylphenidate hydrochloride (Ritalin) has been used to treat both depression and apathy. Although it can be useful for apathy, there is little reason to prefer it over a tricyclic antidepressant in the treatment of depression. Side effects and drug interactions are generally not limiting, and methylphenidate is tentatively recommended for the patient whose apathy is jeopardizing his care.

Clinical Trials as Topic↗
PubMed1980

Treatment of chronic pain with tricyclic antidepressants.

Tricyclic antidepressants are increasingly being used to treat chronic pain. A review of the literature supports their use in a variety of conditions and sheds some light on the question as to whether they exert a direct analgesic effect or act indirectly, by first alleviating an intercurrent depression. Their use is recommended for chronic pain before resorting to narcotics or neurosurgery.

Antidepressive Agents, Tricyclic↗
PubMed1979

Rapid treatment of psychosis with haloperidol.

Rapid parenteral treatment of agitated psychotics is now possible with haloperidol. A review of its pharmacology and clinical trials is presented, and protocols are derived which will rapidly effect and maintain a substantial remission in a majority of cases.

Haloperidol↗
PubMed1969

Influence of calcium and magnesium on manganese absorption.

Mutual effects between Mn, Ca, and Mg were studied during steady-state absorption experiments with excised barley roots. Calcium appeared to enhance the rate of Mn absorption; whereas, Mg had a highly depressive effect. The combination of both Ca and Mg was even more inhibitory to Mn absorption than Mg alone. Manganese had no effect on the usual negligible Ca absorption by this tissue, but effectively inhibited the absorption of Mg. Although divalent cation absorption from the Ca-Mg-Mn system was essentially nil, K absorption was greatly stimulated in the presence of these cations. These mutual effects and others reported in the literature are explained by the hypothesis that selectivity in ion absorption results from cation-induced conformational changes in the structure of the carrier molecule.

Calcium↗
PubMed1968

Manganese absorption by excised barley roots.

Short-term absorption studies with 5-day-old excised barley roots revealed that the basic aspects of Mn absorption were similar to those of other metabolically absorbed cations. Following an initial non-metabolic equilibration with the root, Mn was absorbed for several hours at a slower steady-state rate comparable to that of other inorganic cations. Complete or nearly complete inhibition of the steady-state phase by low temperature, dinitrophenol, and azide provides strong evidence that Mn transport into this tissue was metabolically mediated. Within limits, the rate of transport was strongly dependent upon the concentrations of Mn and the hydrogen ions in the ambient solution. Absorption increased rapidly with increasing concentrations of Mn up to 1 meq per liter. Above this concentration, the rate leveled off, apparently due to a saturation of the transport mechanism. Within the physiological pH range in which Mn is soluble (below pH 7), absorption increased greatly with decreasing hydrogen-ion concentration.

Journal Article↗