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Biomedical subjects

D P Milzman

Publications and source records attributed to D P Milzman.

18 recordsLinked to original sources
PubMed1999

Lightning strikes at a mass gathering.

Among natural disasters, lightning is a leading cause of morbidity and mortality throughout the world. A well-informed bystander and an astute physician can make the difference between an outcome of death or lifelong disability versus complete or near-complete recovery. What is done in the first few minutes after such an event is the predominant predictor of success. This case report describes a young woman who was struck by lightning while talking on a cellular telephone at a mass gathering in an outdoor stadium. The discussion that follows the case centers on the pathophysiology of being struck by lightning and on issues unique to being struck in a stadium full of people.

Adult↗
PubMed1999

Focused care of pediatric patients in the dental office.

No dental text can adequately prepare the practitioner with the necessary expertise to treat all presentations or office complications that may arise in the therapy of children. There are times when consultation with the child's parent and pediatrician may answer necessary treatment-related questions. Most chronic conditions do not prevent needed treatment interventions. Any acute illness or exacerbation of a chronic disease should be cleared by the primary care physician before commencing dental treatment. The mainstay of safe practice requires that the dentist to maintain a basic level of understanding of what constitutes an emergency and that office staff receive basic training and are adequately supplied with emergency equipment. Dentists are cautioned to consult their state board or dental society as well as their insurance carrier as to what constitutes necessary emergency equipment in the office and to what level they are responsible for providing emergency care to their patients. There is a great difference within the dental field just as there is with medical specialties. All practitioners, however, are liable for any acts of consignment, and although the intention is not to dissuade anyone from providing assistance in an emergency, supportive care and an immediate call of 911 to activate the local EMS are important. In addition, maintaining a familiarity with the local hospital and emergency department capabilities as well as travel time and distance is also important. Routine reviews and updates on life-saving interventions and resuscitations are good general practice and will save lives.

Child↗
PubMed1998

Multicenter study of noninvasive monitoring systems as alternatives to invasive monitoring of acutely ill emergency patients.

BACKGROUND: Recent reports showed lack of effectiveness of pulmonary artery catheterization in critically ill medical patients and relatively late-stage surgical patients with organ failure. Since invasive monitoring requires critical care environments, the early hemodynamic patterns may have been missed. Ideally, early noninvasive hemodynamic monitoring systems, if reliable, could be used as the "front end" of invasive monitoring to supply more complete descriptions of circulatory pathophysiology. OBJECTIVES: To evaluate the accuracy and reliability of noninvasive hemodynamic monitoring consisting of a new bioimpedance method for estimating cardiac output combined with arterial BP, pulse oximetry, and transcutaneous PO2 and PCO2; we compared this system of noninvasive monitoring with simultaneous invasive measurements to evaluate circulatory deficiencies in acutely ill patients shortly after hospital admission where invasive monitoring was not readily available. We also preliminarily explored early differences in temporal hemodynamic patterns of survivors and nonsurvivors. DESIGN AND SETTING: Prospective comparison of simultaneous invasive and noninvasive measurements of circulatory function with retrospective analysis of data in university-run county hospitals, university hospitals and affiliated teaching hospitals, and a community private hospital. PATIENTS: We studied 680 patients, including 139 severely injured or hemorrhaging patients in the emergency department (ED), 129 medical (nontrauma) patients on admission to the ED, 274 high-risk surgical patients intraoperatively, and 138 patients recently admitted to the ICU. RESULTS: A new noninvasive impedance device provided cardiac output estimations under conditions in which invasive thermodilution measurements were not usually applied. There were 2,192 simultaneous bioimpedance and thermodilution cardiac index measurements; the correlation coefficient, r = 0.85, r2 = 0.73, p < 0.001. The precision and bias was -0.124+/-0.75 L/min/m2. Both invasive and noninvasive monitoring systems provide similar information and identified episodes of hypotension, low cardiac index, arterial hemoglobin desaturation, low transcutaneous O2, high transcutaneous CO2, and low oxygen consumption before and during initial resuscitation. The limitations of noninvasive systems were described. CONCLUSIONS: Noninvasive monitoring systems gave continuous displays of physiologic data that provided information allowing early recognition of low flow and poor tissue perfusion that were more pronounced in the nonsurvivors. Noninvasive systems may be acceptable alternatives where invasive monitoring is not available.

Adult↗
PubMed1997

ED use of rapid lactate to evaluate patients with acute chest pain.

STUDY OBJECTIVE: To test the hypothesis that ED arrival venous lactate levels can be used to diagnose acute myocardial infarction (AMI) and to identify patients with critical illness in the triage of ED patients presenting with chest pain. METHODS: This was a prospective, double-blind, clinical study in an urban, academic ED. We enrolled a convenience sample of adult patients who had chest pain or cardiac symptoms suggesting AMI that began within 24 hours of presentation. Patients underwent standard medical management for their chest pain. Venous lactate samples were analyzed in the ED on whole blood. An abnormal lactate level of 1.5 mmol/L or higher at the time of arrival was prospectively defined as indicating the presence of acute cardiac disease. ECG findings, levels of creatine phosphokinase (CK) and CK-MB, hospital stay data, and diagnosis of AMI by the cardiology admitting team were recorded. RESULTS: Of the 129 patients included in the study, 73 had an initial lactate level of 1.5 mmol/L or higher. The mean lactate level (+/- SD) for all patients was 1.8 +/- 1.2 mmol/L. A total of 28 patients (21%) were diagnosed with AMI and had a mean lactate level of 2.2 +/- .7 mmol/L, compared with 1.7 +/- 1.3 mmol/L in those patients who were not diagnosed with AMI (P < .03). The sensitivity of this lactate level in diagnosing AMI was 96% (95% confidence interval [CI], 89% to 100%), and the specificity was 55% (95% CI, 45% to 64%). The negative predictive value of blood lactate was 98% (95% CI, 95% to 100%). Lactate was elevated independent of the duration of chest pain symptoms, with a median time from onset to sampling of 3 hours. Lactate was elevated in patients who either died or required longer than 48 hours of ICU care, compared with survivors not requiring ICU care (4.5 +/- 4.3 mmol/L versus 1.4 +/- .6 mmol/L, respectively; P < .01). CONCLUSION: The blood lactate concentration obtained on ED arrival identifies those chest pain patients with critical cardiac illness (eg, AMI, severe congestive heart failure [CHF], decompensated arrhythmias). A normal blood lactate result has a high negative predictive value for AMI. An elevated lactate level used in conjunction with ECG and history distinguishes patients with significant myocardium at risk who are likely to benefit from more urgent attention and interventions by the attending physician. Additionally, hyperlactatemia clearly correlates with mortality and the need for ICU management in the acute cardiac patient presenting to the ED.

Adult↗
PubMed1996

Resuscitation of the geriatric patient.

The elderly represent the fastest-growing segment of the population. As the country ages, the number of elderly patients who present in extremis will undoubtedly increase. Emergency physicians must be cognizant of the fact that age alone is a poor predictor of outcome in the critically ill elderly patient. Premorbid status, including previous level of functioning and pre-existing disease, is more important than chronologic age in predicting outcome, guiding assessment, and deciding on therapy. Knowledge and consideration of the geriatric ABCs includes a fundamental understanding that loss of protective airway reflexes, occult respiratory insufficiency, and clinically unrecognized shock are especially prevalent in the sickest geriatric patients. Early recognition and treatment can minimize morbidity and mortality rates in the ED.

Aged↗
PubMed1995

Creating a dignified option: ethical considerations in the formulation of prehospital DNR protocol.

Increasing numbers of states are recognizing the importance of developing policies to allow Do Not Resuscitate (DNR) orders to be recognized in the prehospital setting, especially by emergency medical personnel. The ethical issues involved in creating such policies have not been widely addressed. Using the experience of developing such a policy for the District of Columbia as a model, we discuss six major ethical issues involved in prehospital DNR order policy development. 1) Can the justification for the policy be grounded in the doctor's duty of beneficence? 2) Should the concept of futility be applied to prehospital DNR orders? 3) How specific should prehospital DNR orders be? 4) How can one maximize patient participation in the prehospital DNR decision? 5) How much consideration ought to be given to the scarcity of health care resources in the development and justification of such policies? 6) Should paramedics be empowered to pronounce DNR patients dead in the field? This discussion ought to be of benefit to all those involved in developing or revising prehospital DNR policies.

Advisory Committees↗
PubMed1995

Infrared emission detection tympanic thermometry may be useful in diagnosing acute otitis media.

To determine the utility of infrared emission detection (IRED) tympanic thermometry in diagnosing acute suppurative otitis media (ASOM), a prospective, nonblinded sampling of ear temperatures was performed. Children between the ages of 6 months and 6 years presenting to an urban emergency department were included in the study. Tympanic temperatures were determined in all subjects. Clinical data, tympanic audiometry, and telephone follow-up were used to define ASOM. Temperature differences were determined for children with unilateral ASOM and those without ear infection. Data from 48 patients were analyzed. The mean temperature difference in the control group, 0.23 degrees +/- 0.15 degrees C (95% confidence interval [CI], 0.17 degree to 0.29 degree C) differed from those with ASOM: 0.39 degree +/- 0.29 degree C (95% CI, 0.25 degree to 0.53 degree C, P = .047). Logistic regression was used to describe the predictive relationship between temperature difference and probability of ASOM. We conclude that IRED tympanic thermometry may be useful in diagnosing ASOM when used with other clinical data.

Acute Disease↗
PubMed1994

Substance use disorders in trauma patients. Diagnosis, treatment, and outcome.

The consequences of acute and chronic drug abuse pose significant problems for physicians managing the trauma victim in the resuscitative, perioperative, intensive care, and hospitalization periods. Substance abuse, whether acute or chronic, modifies the physiologic response to injury and to resuscitative and operative measures. Trauma and critical care physicians must have insight into ways to improve the detection, resuscitation, and management of trauma patients with acute substance intoxication or chronic abuse history. The need for prophylaxis of withdrawal syndrome differs with drug type. The major difficulty is proper identification of individuals at risk, which is complicated by patients' unconsciousness, reluctance, or medical inability to give detailed history of substance use. Failure to recognize withdrawal symptoms may both confuse the diagnosis of traumatic injury and be life-threatening. The goal in treating the trauma patient who is also a substance abuser is both to fully assess that person's injuries and achieve physiologic stability and use the hospitalization as an opportunity to educate and counsel the patient to abandon his or her destructive behavior.

Alcoholism↗
PubMed1994

Obesity.

Although obesity and trauma both are common in the general population, discussion of the care of the critically injured obese patient has been relatively absent. Obesity is associated with significant clinical and occult multisystem disease. Because host factors are key determinants of post-traumatic course and outcome, obesity appears to be a marker of high risk. Obesity should be considered with age, pregnancy, cardiopulmonary disease, and substance abuse as a host factor that has significant post-traumatic ramifications. Only by employing a comprehensive, multidisciplinary approach to the critical care management of such patients will post-traumatic complications be prevented and treated effectively.

Humans↗
PubMed1993

A comparison of right and left blunt traumatic diaphragmatic rupture.

Since right blunt traumatic diaphragmatic rupture (BTDR) is reported with increasing frequency, BTDR may be a disease in evolution. Data were collected on 59 left, 16 right, and five bilateral BTDRs at a level 1 trauma center. Patients with right BTDR had lower Glasgow Coma Scale (GCS) scores (p < 0.05), were more likely to be initially in hypovolemic shock, and were admitted directly from the field (p < 0.01). Left and right BTDRs were diagnosed from chest films in 37% and 0% of cases, respectively (p < 0.05). Diagnostic peritoneal lavage results were negative in 16% of left and left of 0% of right BTDRs. For right BTDRs, the liver was more likely to be injured (p < 0.001). The mortality rates were similar and ICU and hospital stays, complications, and duration of mechanical ventilation were similar for early survivors with right and left BTDRs. The clinical signs and symptoms, diagnosis, and surgical findings associated with right and left BTDR are different.

Adolescent↗
PubMed1993

The clinical significance of acute hyperamylasemia after blunt trauma.

The clinical value of total serum amylase (TSA) levels measured after blunt trauma remains controversial. To test the utility of this measurement, the authors surveyed the routine admission TSA levels of 4316 adults who were victims of blunt trauma. Most patients (58.2%) had been injured in motor vehicle accidents, and all were admitted directly from the accident scene. Patients were divided into two groups based on the admission TSA level: more than 125 U/L (abnormal) and 125 U/L or less (normal). Of the 4316 patients, 3920 (90.8%) had a normal TSA level upon admission. Hyperamylasemia was associated with a greater injury severity score (ISS) and death rate, a lower admission Glasgow Coma Scale score and an increased incidence of facial fracture, brain injury, pancreatic and hollow-viscus injuries and hypotension (p < 0.01). However, the positive predictive value of an abnormal TSA level for pancreatic and hollow-viscus injuries was 1.5% and 3.0% respectively. Also, most patients with pancreatic (65%) and hollow-viscus (83%) injuries had a normal TSA level. There was no relation between the anatomic grade of pancreatic injury and the TSA level. Acute hyperamylasemia after blunt trauma appears to be a poor predictor of pancreatic and hollow-viscus injuries. Therefore, urgent TSA determinations should not influence the clinical and radiologic evaluation of the blunt trauma victim.

Abdominal Injuries↗
PubMed1993

Overview and outcomes.

A great deal of progress has been made regarding improved prehospital transport, the quality of trauma care, and injury prevention research. The analysis of the four determinants of outcome in the trauma victim allowed for the discovery of subgroups who may benefit from a change in triage, resuscitation, or management. Our recent investigation into the effect of host factors on mortality resulted in the discovery that pre-existing illness predicts outcome independent of other determinants, including age and ISS. This article serves as an introduction to the effect of PED on trauma victims, including prevalence of specific PED, as well as disease-specific treatment considerations. The bottom line in care of any trauma victim is that all deviations from normal must be noted, but they should be evaluated properly with respect to the acute injuries. It is the authors' hope that this overview will guide the intensivist in focusing on the treatment of acute injuries without losing sight of the importance of both recognizing and managing chronic illnesses so their detrimental effect on patient outcome can be minimalized. A large multicenter investigation is needed to see whether these recommendations will, in fact, positively impact on trauma victim outcome.

Age Factors↗
PubMed1992

Hyperbaric medicine for outpatient wound care.

After proper cleansing, debridement, and appropriate antibiotic and closure decisions, some wounds will fail to heal properly or may develop serious complications. Hyperbaric oxygen therapy offers a relatively safe noninvasive method of improving wound healing by enhancing tissue oxygenation and decreasing edema formation. Recommendation for the use of hyperbaric oxygen therapy in outpatient wound care is reviewed and the rationale behind the benefits is discussed.

Ambulatory Care↗
PubMed1992

Pre-existing disease in trauma patients: a predictor of fate independent of age and injury severity score.

Improvement in trauma management requires a better understanding of the effect of a patient's preinjury health status on outcome. Specific historical findings and laboratory criteria were used to define pre-existing disease (PED) states and determine if they were independent predictors of fate in trauma victims. Of 7,798 adult patients admitted to a level I trauma center from July 1986 through June 1990, 16.0% (1,246) had greater than or equal to 1 PED. The PED+ and PED- patients had no significant difference in Injury Severity Scores (ISSs) (15.7 versus 15.6) and admission Glasgow Coma Scale (GCS) scores (13.9 versus 13.8). The PED+ patients were older (49.2 versus 30.6 years) (p less than 0.001) and had a higher mortality rate (9.2% versus 3.2%) (p less than 0.001) than PED- patients. Mortality rates were also elevated for patients with greater than or equal to 2 PEDs (18%) and for those with renal disease (38%), malignancy (20%), and cardiac disease (18%) (p less than 0.001) compared with PED- patients. Controlling for age and ISS, there was an association between PED and mortality (Mantel-Haenszel p less than 0.03). Multivariate regression showed that PED is an independent predictor of mortality (R2 = 0.1918; p less than 0.0001). The greatest increases in mortality were found among patients less than 55 years and with ISS less than 20. Changes in prehospital triage criteria and outcome scoring are needed. Improvements in the management of trauma victims with chronic disease may decrease their mortality rate.

Adult↗
PubMed1991

Flumazenil & coma.

Explore the source record for details and available documents.

Cerebrovascular Circulation↗
PubMed1989

Iatrogenic bilateral tibial fractures after intraosseous infusion attempts in a 3-month-old infant.

A 3-month-old girl presented to the emergency department with a clinical picture compatible with sepsis. When peripheral IV cannulation could not be attained, intraosseous (IO) access was attempted unsuccessfully in both tibias as well as in the right femur. The child was subsequently treated for S pneumoniae meningitis. Three days after discharge and 14 days after initial presentation, the family noticed swelling of the child's right leg. Radiographs revealed healing fractures of both proximal tibias. This case represents a previously unreported complication of intraosseous infusions and underscores the need for the use of proper technique and equipment.

Bone and Bones↗