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Biomedical subjects

D P Kimble

Publications and source records attributed to D P Kimble.

30 records · Page 2Linked to original sources
PubMed1967

Activity and responsivity in rats after magnesium pemoline injections.

Rats injected intraperitoneally with magnesium pemoline avoided a buzzing sound (conditioned stimulus) associated with an electric shock to the feet (unconditioned stimulus) more frequently than controls. Drug-injected rats did not avoid the foot shock more frequently than controls, although the experi mental rats did have shorter response latencies fn the active avoidance task. In sub sequent experiments which measured activity changes and response to the buzzing sound alone, it was found that magnesium pemoline caused a lesser decrease in activity level and a more sustained responsivity to the buzzer's. sound than did control injections of tragacanth. This may account for the latency differences observed in the avoidance task.

Animals↗
PubMedDate not supplied

Met-enkephalin effects on associations formed in utero.

Rat fetuses exposed to an odor stimulus and an aversive stimulus in utero showed an aversion to the odor when tested 16 days postnatally. Fetuses that also received 80 micrograms/kg Met-enkephalin showed a greater aversion to the odor stimulus than those subjects that did not receive the peptide. The difference between these groups was marginally significant. Control subjects did not show an aversion. But, subjects exposed to the odor and Met-enkephalin without the aversive stimulus, when tested, showed a significant preference for the odor over other control groups. These data show that associative learning in rat fetuses at 20 days of gestation may be enhanced by administration of Met-enkephalin.

Animals↗