Biomedical subjects

D P Esposito

Publications and source records attributed to D P Esposito.

4 recordsLinked to original sources

PubMed2001

Age-related changes in P2 receptor mRNA of rat cerebral arteries.

Aging alters the vascular response to extracellular nucleotides. However, the molecular mechanisms that underlie the effect of aging remain unclear. We investigated the mRNA expression of P2X(1), P2Y(1), P2Y(2) subtypes of the nucleotide receptors (P2) in the basilar artery, aorta and carotid artery from male Sprague-Dawley rats, 2-months and 19-months old. In the basilar arteries of 19-month old rats, as compared to the 2-month old rats, the P2X(1) receptor transcripts were reduced and the P2Y(1) and P2Y(2) receptor mRNA was increased. In the aorta and carotid arteries, P2Y(1) receptor mRNA was decreased in the 19-month old rats when compared to the 2-month old rats. There were no marked changes of P2X(1) and P2Y(2) receptor mRNA between the two age groups in the aorta or carotid artery. In endothelial cells, P2Y(1) and P2Y(2) receptor mRNA was reduced with age. We concluded that, down-regulation of P2X(1) and up-regulation of P2Y(1), P2Y(2) receptor mRNA in smooth muscle cells and down-regulation of P2Y(1) and P2Y(2) receptor mRNA on vascular endothelial cells might underlie the changes of cerebral vascular tone in aging.

Aging↗

PubMed1993

Use of lumbar run-up technique for cervical myelography.

Cervical myelography by lumbar run-up produces excellent radiologic studies in most cases. Use of this technique avoids the hazards and pitfalls associated with a lateral cervical puncture. We discuss 92 cases, with excellent or good results in 98% and nondiagnostic studies in only 2%. Both of the poor technical studies were followed by computed tomographic myelography to produce diagnostic examinations in all cases. There were no serious complications.

Cervical Vertebrae↗

PubMed1984

Interhemispheric subdural hematoma.

We have reported a case of primary interhemispheric subdural hematoma with successful surgical removal. Paresis of the lower extremity out of proportion to the arm and face may provide a clue to the location of the lesion. Although CT is the most valuable single diagnostic procedure, carotid angiography is needed to exclude a vascular lesion.

Hematoma, Subdural↗

PubMed1984

Acute anterior spinal epidural abscess.

We have reported a case of acute spinal epidural abscess, an uncommon cause of pain in the neck and back. The typical progression from spinal ache to paralysis may be halted if the diagnosis is suspected and prompt radiologic and surgical interventions are initiated.

Abscess↗