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Biomedical subjects

D Orstavik

Publications and source records attributed to D Orstavik.

At least 55 records · Page 3Linked to original sources
PubMed1985

Mutagenicity of endodontic sealers.

Four endodontic sealer materials and some of their chemical constituents were subjected to Ames' test for mutagenicity with the Salmonella/microsome assay. Extracts of two zinc oxide-eugenol based materials and of one gutta-percha-zinc oxide-chloroform based sealer were negative in the test. Extracts of a synthetic polymer material, based on epoxy-bis-phenol A, induced mutations in Salmonella typhimurium TA 100 as did extracts of the epoxy-bis-phenol A resin alone. Formaldehyde, an active ingredient from one of the ZnO-based materials, induced mutations in both Salmonella typhimurium TA 98 and TA 100. The mutagenic activity of formaldehyde as well as of the epoxy material was reduced in the presence of rat liver microsomes.

Administration, Topical↗
PubMed1985

Influence of antiseptic storage solutions on physical properties of endodontic guttapercha points.

The effect of three commonly used antiseptic storage solutions on some physical properties of endodontic guttapercha points was studied. The solutions tested were: 70% isopropyl alcohol, 5% chloramine and 0.5% chlorhexidine. As a control solution, physiologic saline was used. There was a marked decrease in the force necessary to bend the points after 1 month. With few exceptions, the greatest decrease was seen with solutions containing alcohol, i.e. chlorhexidine and isopropyl alcohol. The difference between aqueous and alcoholic storage solutions was also noted for linear dimensional changes. Physiologic saline and chloramine hardly affected the length of the points. The decrease in stiffness may add to the difficulties when handling guttapercha points of small dimensions in curved root canals. From this point of view it is therefore recommended to avoid storage of points in antibacterial solutions. Rather, an effective surface disinfecting of the points immediately prior to use would be desirable.

1-Propanol↗
PubMed1985

Bacteriological studies on endodontic paper points.

Four brands of endodontic paper points were subjected to tests for sterility, antibacterial activity, and suitability as vehicles for bacteriological sampling procedures. No brand showed growth in the sterility assay. One brand showed weak but reproducible antibacterial activity. Recovery of viable bacteria after absorption into the points varied and appeared to depend both on the brand of point and on the bacterial strain used. One brand appeared ineffectual for clinical bacteriological sampling procedures.

Bacteria↗
PubMed1985

Antibacterial properties of and element release from some dental amalgams.

Nine commercial dental amalgams were tested for antibacterial properties in vitro. A bactericidal test on salivary bacteria, a growth inhibition test on Streptococcus mutans OMZ 176, and a time-dependent bactericidal test on Strep. mutans were used. All amalgams displayed some antibacterial properties. Dispersalloy and Revalloy were strongly antibacterial in all tests; ANA 2000 and Sybraloy killed Strep. mutans but were less potent in the salivary test and in the growth inhibition experiments. The copper amalgams, Neo-Silbrin and Cupromuc, were the most active in the salivary test but less inhibitory in the growth curve experiments. Spheraloy, Indiloy, and Amalcap showed intermediate activity in the salivary bactericidal test but were relatively weak in the growth inhibition studies. Analysis of Hg, Ag, and Cu in media from the growth inhibition studies showed release of Hg from the copper amalgams and, particularly, from Revalloy; Indiloy gave off Ag, whereas Neo-Silbrin, Cupromuc, Sybraloy, and ANA 2000 released more Cu than the other brands.

Bacteria↗