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Biomedical subjects

D Oppenheim

Publications and source records attributed to D Oppenheim.

44 records · Page 3Linked to original sources
PubMedDate not supplied

Nasal histamine challenge: a method to predict the efficiency of antihistamine treatment.

Nasal histamine challenge (NHC) was performed on patients suffering from chronic rhinitis. The histamine was administered to the nose in the form of a spray. One hundred sixty-eight patients and 20 healthy subjects were examined. The histamine was sprayed into the nose in seven metered doses, from 0.03 mg to 3 mg. The nose was examined before and 4 minutes after each challenge. A positive reaction to challenge was indicated when the conchae swelled to the point that they impinged against the septum. We found that some patients reacted to a low dose of histamine (0.03 mg to 0.15 mg) while our control group and some other patients reacted positively only to higher doses of histamine (3 mg or more). After the first tests, NHC patients were randomly divided into two groups. One group was treated with placebo and the other group with antihistamines. Three weeks later another NHC was performed (now under treatment) and revealed that patients reacting to low doses of histamine improved significantly with antihistamine treatment, while those reacting to a high dose did not respond to antihistamines. We found the NHC to be a simple test with no complications, and one that is easily tolerated by patients, including children. Nasal histamine challenge helps to identify which patients will improve with antihistamine treatment and aids the evaluation of its efficacy.

Adolescent↗
PubMedDate not supplied

Personal freedom and genetic overdetermination.

We do not intend to specify definite proposals as regards the scientific responsibility of genetic practice. This field of predicting the development of a pathology in an individual and family history requires reflection on the perception of personal risk, of the importance and reassurance deriving from a personal history, and of the benefits sharing knowledge and care with the clinical and scientific world. We evaluate the possibility to expand a reflection on sign-possibility and sign-expression of disease that could develop a wider comparison with personal freedom when confronted by genetic, philosophical and historical determinations. A parallel and preliminary consideration is made of guidelines for diagnostic and therapeutic behavior.

Genetic Diseases, Inborn↗
PubMedDate not supplied

[Life experience by children with brain tumors].

The long-term evolution (intellectual, affective, social) of children cured of their cerebral tumor is far from being satisfactory, despite progress in neurosurgery, chemotherapy and radiotherapy. The feelings of these children and of their family have rarely been studied. The author, on the basis of 60 interviews with such children and their parents, pinpoints the great violence of feelings and situations: feelings of terror, of non-sense, disturbance of the feeling of identity, breaking of relationships, loss of time landmarks. The psychological consequences can be severe: such as being enclosed in a frozen time wrap, and experiencing a lack of social life. If we knew the feelings of these children better, then we could start preventive actions (psychotherapy and specialized rehabilitation) early enough to avoid sequels which cannot be attributed, for all of them, to cerebral damage.

Adolescent↗
PubMedDate not supplied

[Psychoanalytic study at a pediatric oncology department].

The place of a psychoanalyst in a Paediatric Oncology Department is described. Unfortunately mutual ignorance, mistrust and fear continue to be obstacles to the integration of psychoanalysts in medical teams. The conditions required for the work of the psychoanalyst to be possible are underlined: he must be fully integrated into the team and should have sufficient time to devote to his work. Parents should have unhindered access to the unit. Pain must be recognized and treated. It is important that the members of the staff are aware of and sensitive to the different aspects of his work (a Balint type of group might help to achieve this objective). The analyst will intervene when he has pinpointed psychic distress in the child; he will sometimes have to search for it in the parents, among siblings, and even among the medical and non medical members of the staff, where it is discrete or even concealed. All staff members should be sensitive to this distress and anguish, because each and every one of them could be chosen by the child to bear witness to the problem or to discuss it with him/her. The members of the staff should be trained to be sensitive to this distress so that they can direct the child towards the psychoanalyst soon enough. The psychoanalyst should adapt his techniques so that they are in keeping with hospital conditions. His work is not conventional psychoanalytical treatment nor wild, haphazard interpretations but rather psychoanalytical meetings which are often intense, brief and rare. Five case reports illustrate these different aspects.

Adolescent↗