Biomedical subjects

D Oltmanns

Publications and source records attributed to D Oltmanns.

31 records · Page 2Linked to original sources

PubMed1979

[Fructose tolerance and utilization in healthy and chronically diseased liver].

In 12 patients with liver cirrhosis (LC) and 11 normal subjects (N) equimolar (0.75 g/kg/h for 4 hrs.) 14C-(1)-glucose and 14C-(1)-fructose infusions were administered. When given fructose, N and LC showed only a small increase of serum-glucose and -fructose concentrations in steady state. In N and LC the total fructose clearance was significantly higher than the total glucose clearance. No differences were found between N and LC. The metabolic clearance was equal in both groups when given fructose, whereas during glucose infusion lower in LC than in N. 30% of the infused 14C-fructose were recovered in 14C-glucose. The renal loss in both groups was higher for glucose than for fructose. A more extensive renal 14C-excretion during infusion of 14C-fructose was due to a higher 14C-lactate excretion.

Carbon Radioisotopes↗

PubMed1979

[Pharmacokinetics of lidocaine after intramuscular injection in patients with acute myocardial infarction (author's transl)].

The kinetics of lidocaine after i.m. injection (M. deltoideus) of 300 mg were studied in patients with acute myocardial infarction in the course of 4 hrs.; another patient received this i.m. dose after being pretreated with 100 mg lidocaine i.v. The antiarrhythmically effective threshold concentration in plasma (1.5 mg/l) was reached after an average time of 5.5 min by 9 out of 10 patients. The mean value of maximum concentration after 30 min was 3.6 mg/l in 10 patients and the mean duration for exceeding the threshold (1.5 mg/l) was about 2 hrs. The elimination half-life for lidocaine valued 1.77 hrs. The toxic threshold concentration of 6 mg/l was exceeded for a short time by 3 patients without any side effects; in three other patients suffering from side-effects no relation to high plasma levels of lidocaine was observed.

Acute Disease↗

PubMed1979

[Comparative studies on the use of equimolar 14C-labeled glucose and fructose infusions in normal subjects and patients with liver cirrhosis].

In 11 normal subjects (NS) and 12 patients with liver cirrhosis (LC) the utilisation of 14C-glucose and 14C-fructose infusions (0.75 g/kg/h for 4 h) was compared. There were nor relevant side effects. Lactate and pyruvate were in both groups during fructose infusion slightly increased compared to glucose infusion. The free fatty acids were significantly decreased. The serum glucose level rose more in LC than in NS when given fructose infusion. During glucose and fructose infusion in LC higher insulin concentrations were calculated than in NS. 15 min after infusion of 14C-fructose 20% of the total serum activity was 14C-glucose, after 2 to 4 h the level was 30%. Differences between NS and LC were not found to be significant. The specific activity of 14CO2 was the same in both the 14C-glucose infusion and the 14C-fructose infusion. The glucose oxidation was impaired in LC, but not the 14CO2-exhalation during infusion of 14C-fructose. Unimpaired 14CO2-exhalation, and normal utilisation and conversion to glucose are arguments for the use of fructose in infusion treatment of cirrhotics.

Blood Glucose↗

PubMed1978

[Simultaneous enzyme determination of C-14 glucose and C-14 fructose in human body fluids].

A new enzymatic method for simultaneous estimation of radioactivity of 1-14C-glucose and 1-14C-fructose is described. It is based on the isomerisation of 1-14C-fructose to 1-14C-glucose by phosphoglucoseisomerase (EC 5.3.1.9) and on its enzymatic removal as ribulose-5-phosphate and 14CO2. The method is specific, reproducible, and gives over 97% recoveries of glucose and fructose concentrations up to 11 mmol/1 in aquos and biological solutions.

Body Fluids↗

PubMed1977

[The effect of fructose on glucose formation and oxydation in healthy subjects and patients with liver cirrhosis].

The effect of fructose infusions (1.0 g/kg/g) on serum glucose, insulin, lactate, free fatty acids, glucose production and glucose oxidation was investigated with 14C-glucose in 10 normals and 11 patients with liver cirrhosis. Elevation of glucose and insulin were small and only slightly higher in cases of cirrhosis. Decrease of free fatty acids and rise of lactate were approximately the same in both groups. During infusion of fructose glucose turnover increased up to 196 +/- 41% in the normals and up to 279 +/- 78% in the patients with cirrhosis. No influence on the specific activity of 14CO2 was observed. It was therefore suggested, that approximately the same amount of glucose leaving the liver in excess during infusion of fructose was taken up by the liver at the same time. This behaviour of glucose supply to the blood stream and removal from it would explain, why high rates of conversion of fructose to glucose were measured with 14C-fructose, while only small amounts of glucose production were estimated from hepatic arteriovenous differences.

Fatty Acids, Nonesterified↗

PubMed1974