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Biomedical subjects

D Olive

Publications and source records attributed to D Olive.

At least 253 records · Page 14Linked to original sources
PubMed1983

[Course of diaphyseal dysplasia. Camurati-Engelmann disease followed for 14 years].

The authors report a case of a child with Camurati-Engelmann disease de Camurati-Engelmann followed-up for 14 years. The diagnosis was made at the age of 5 years, with a typical picture. During the course of the disease, certain discordant facts emerged with, in particular, the appearance of osteoporotic lesions in the pelvis, metaphyses, epiphyses and skull. This led to the possibility of other diagnoses being envisaged but none could be made definitely. Furthermore, the osteoporotic lesions could not be explained by corticosteroid therapy which was taken in too irregular a manner. Is there a borderline disease within the broad definition of diaphyseal dysplasia?

Bone Diseases, Developmental↗
PubMed1982

Improvement of cellular immunity and IgA production in immunodeficient children after treatment with synthetic serum thymic factor (FTS).

Three children with IgA and IgE deficiency and T-cell defects (two related patients with ataxia telangiectasia and one with common variable immune deficiency) were treated with synthetic serum thymic factor (FTS) intravenously. A reduction in frequency and severity of infection was noted concomitantly with improvement in cell-mediated-immunity tests. Serum IgA, which was absent in two patients, appeared within 4 weeks of treatment and increased significantly in the third patient. Specific antibodies against vaccination antigens appeared for the first time or increased to titres higher than ever before. In two patients, transient interruption of FTS administration was followed by a regression of the immunological improvement, but this disappeared after the treatment was started again.

Adolescent↗
PubMed1982

In vitro induction of monoclonal antibody-defined T-cell markers in lymphocytes from immunodeficient children by synthetic serum thymic factor (FTS).

Lymphocytes from five children suffering from ataxia telangectasia or various unclassified immune deficiencies were tested in vitro for their sensitivity to synthetic serum thymic factor (FTS). The percentages of cells bearing T cell markers were elevated after incubation with FTS at graded concentrations (0.25, 2.5 and 25 ng/ml), by microlymphocytotoxicity or indirect immunofluorescence, using monoclonal anti-Lyt1 antibodies. In four cases, more than 30% of the non-T non-B cells acquired the Lyt1 T cell marker. These four children had low levels of circulating FTS. In the fifth child, who had a normal serum FTS level, and in two age-matched controls, there was no significant increase in the percentage of cells bearing the T marker.

Adolescent↗
PubMed1982

[Bilateral hamartoma of the chest wall].

Because its extreme rarity, a case of a bilateral chest wall hamartoma is reported in an 7 months infant presenting a moderate thoracic deformation. Roentgenogram reveals a segmentary costal destruction and an adjacent intrathoracic mass. A right thoracotomy is realized and the tumor is removed without difficulties. Diagnosis of a vasculo-cartilaginous hamartoma (other term used: mesenchymoma) is confirmed after the resection of the right lesion, whereas the left one is spontaneously reducing within 7 months. After analysis of 20 previously reported identical cases, we think that diagnosis may be done on clinico-radiological grounds; surgical decision has to take into account the constant benignity, the possible spontaneous regression and the orthopedic sequelae due to an extensive resection.

Female↗
PubMed1981

[L-asparaginase, antithrombin III deficiency and thromboses (author's transl)].

In 2 children treated for acute lymphoblastic leukemia (ALL), sural phlebitis followed treatment with L-asparaginase. The latter was responsible for a decreased synthesis of antithrombin III (AT III) resulting in low plasma activity. Treatment with heparin was not successful and only fresh plasma led to recovery. The activity of AT III, a progressive inhibitor of thrombin and cofactor of heparin, is always below 50% after L-asparaginase. However, since the risk of thrombosis is very low, interruption of treatment and fresh frozen plasma are needed only when additional risk factors are present.

Adolescent↗
PubMed1980

Application of the study of prognostic factors to the treatment of childhood (less than 20 years old) acute lymphoblastic leukemia.

405 children with acute lymphoblastic leukemia were stratified according to age, initial leucocytes count, lymph nodes, liver and spleen size, into three prognostic classes I, II, III. Protocol 08 LA 74 which they were applied included: 1)initial randomization between Prednisone, Vincristine, Daunorubicin or the same plus Cyclophosphamide for induction and reinductions; 2)doses adjustments to prognostic factors, increased doses being given to increased risk patients; 3)comparison between intrathecal Methotrexate and intrathecal Methotrexate plus Ara-C in addition to skull irradiation for CNS prophylaxis; 4)L-Asparaginase consolidation for all patients; 5)maintenance by 6-Mercaptopurine and Methotrexate in all patients and reinductions. The most striking conclusions to date are the improvement for increased risk patients, the frequency of primary testicular relapses contrasting with the low rate of meningitis, the prognostic implication of sex, the influence on remission duration of the number of courses necessary to achieve complete remission, the importance of using Cox Method to improve the identification of prognostic groups.

Adolescent↗
PubMed1979

[Pulmonary aspergillosis and chronic septic granulomatosis].

Two children with chronic granulomatous disease who developed diffuse pulmonary aspergillosis are described. The outcome was satisfactory in one case with miliary disease because the diagnosis was made early by an open lung biopsy. In the other case the diagnosis was delayed and the child died after 7 months with disseminated haematogenous spread of the fungal infection. Although most of the infections of chronic granulomatous disease are bacterial, the abnormalities of phagocyte killing will also predispose to fungal infections. The prolonged survival of affected children because of antibiotic therapy will increase the risk of parasitic and fungal infections.

Aspergillosis, Allergic Bronchopulmonary↗
PubMed1977

Immunological characteristics of lymphoblasts and lymphocytes in acute lymphoblastic leukaemia in children.

By analysing the electrophoretic mobility (EM) of lymphocytes and by comparing their surface charge it is possible to distinguish rapid-moving lymphocytes (T) and slow-moving lymphocytes (B). The authors studied the EM of blood lymphocytes in children suffering from acute lymphoblastic leukaemia, before they underwent treatment. At the same time they carried out a study of classical immunological markers (E rosettes, membrane immunoglobulins, and blastic-transformation ability). The authors were able to distinguish three types of lymphocytes according to their EM i.e., rapid, slow or intermediate. This heterogeneousness could be explained by the fact that the origin of leukaemic proliferation may vary according to different stages in the maturation of the lymphoid cells. It would seem premature to establish any correlation between the initial clinical signs of the disease and its evolution.

Adolescent↗
PubMed1977

[Periostitis or, rather, periosteal appositions in paediatrics (author's transl)].

In relation to a case of multiple fatigue fractures definitely diagnosed by scintigraphy and xerography, the authors report two other previous cases of spontaneous fractures at a single site in which the diagnosis was made only after surgical biopsy and histological examination. Recalling the frequent confusion arising in children between periosteal appositions and osteomyelitis or Ewing's sarcoma, and the different radiological phases of this type of fracture, they stress the necessity for a maximum effort to demonstrate the key element in the diagnosis: the cortical fissure. The latter is often minimal, at the limit of visibility and developing late. Thus repeated examinations and the use of special radiological techniques are necessary.

Bone Diseases↗