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Biomedical subjects

D O Lewis

Publications and source records attributed to D O Lewis.

79 records · Page 5Linked to original sources
PubMed1968

The role of deoxycorticosterone in the biosynthesis of cardenolides in Digitalis lanata.

The role of deoxycorticosterone in the biosynthesis of digitoxigenin was investigated by the simultaneous administration of deoxy[1,2-(3)H(2)]corticosterone and [4-(14)C]progesterone to a Digitalis lanata plant. The biosynthetically formed [(3)H,(14)C]digitoxigenin and deoxy[(3)H,(14)C]corticosterone were isolated and the distribution of the two isotopes in these products was determined. The transformation of progesterone into deoxycorticosterone in vivo was established. The biosynthetic route from progesterone via deoxycorticosterone to cardenolides was found to be of little significance.

Carbon Isotopes↗
PubMed1967

Progesterone: its possible role in the biosynthesis of cardenolides in Digitalis lanata.

The incorporation of progestrone-7alpha-(3)H and pregnenolone-7alpha-(3)H into digitoxigenin, gitoxigenin, and digoxigenin in isolated, surviving leaves of Digitalis lanata was demonstrated. In addition, the conversion of pregnenolone to progesterone in the same system was proved. The results tend to indicate that progesterone is as good a precursor of cardenolides as pregnenolone It is suggested that the biosynthesis of cardenolides might proceed through the intermediacy of progesterone.

Chromatography, Paper↗
PubMedDate not supplied

Discovering physical abuse: insights from a follow-up study of delinquents.

In a follow-up study of incarcerated Connecticut youth, 66 subjects participated in extensive personal interviews. This paper documents discrepancies between early data regarding abuse and retrospective self-reports of abuse given at the time of follow-up. It describes the development of an interview protocol in which inquiries regarding medical history, the general temperament of caretakers and their behaviors when intoxicated, and instruments and methods of punishment used in the home enabled subjects to describe abusive experiences not disclosed in response to direct questions about maltreatment. The paper also discusses the use of explicitly worded probes to flesh out a clear picture of subjects' experiences. The conflicts that underlie denial or minimization of abuse are discussed, along with interviewing strategies for overcoming them.

Adolescent↗