[Theophylline therapy: patient compliance and dosage. A clinical study].
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Biomedical subjects
Publications and source records attributed to D Nolte.
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In an open study with 306 hospitalized patients with obstructive airway diseases (149 males aged 57.2 +/- 13.0 years, 157 females aged 52.2 +/- 13.9 years), the tolerance of the new sustained-release theophylline preparation Uniphyllin was investigated. The duration of treatment was 3.1 +/- 1.3 weeks (males) or 2.9 +/- 1.2 weeks (females), respectively. For 75% of the male and 85% of the female patients a single evening dosage was sufficient. The number of side effects necessitating discontinuance of the theophylline therapy in females was three times that observed in males. Altogether, the 7.8% drop-out rate was very low, considering the seriously ill patients participating in the study. Accordingly, the new sustained-release theophylline preparation has been tolerated particularly well.
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In 27 asthmatic patients a single cold stimulus into the nose resulted in a sudden increase of airway resistance, measured continuously by a forced-oscillation technique. The effect could be blocked by previous intrabronchial application of an anticholinergic drug. In laryngectomised patients, who no longer have a connection between the upper and the lower airways, a cold stimulus into the nose also caused bronchoconstriction. So the cold effect must be based on a reflex mechanism.
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