Biomedical subjects

D Nikolić

Publications and source records attributed to D Nikolić.

At least 19 recordsLinked to original sources

PubMed1991

[The importance of hormone receptor determination in breast malignancies].

Estrogen and progesterone receptor phenotypes expressed as "positive" or "negative" are widely used for the determination of estrogen dependence of primary breast tumor. In our opinion the receptor phenotype, so important for biological and clinical behavior of tumor, should consider the quantitative values of receptor content. For this purpose, the correlation between quantitative estrogen versus progesterone receptor content and the distribution of the quantitative estrogen and progesterone receptor content within some parameters of tumor and tumor-host was analyzed. Our results show: There is the same range of correlation between estrogen versus progesterone receptor content in tubular tumor type, invasive ductal and lobular carcinomas, and in all three histologic grades; Histologic type influences the estrogen dependence through histologic grade. There is no difference in distribution of the quantitative estrogen and progesterone receptor content when corresponding grades of tubular tumor type, invasive ductal and lobular carcinomas are compared; In premenopause status histologic grade defines different groups with regard to the quantitative progesterone receptor content; In postmenopause status histologic grade defines different groups with regard to the quantitative estrogen and progesterone receptor content; In tumors with histologic grade I, transition of pre to postmenopause status is connected with a significant increase of the frequency of the high quantitative estrogen receptor content; In tumors with histologic grade III, transition of pre to postmenopause status is connected with a significant increase of the frequency of the low quantitative estrogen and progesterone receptor content.

Breast Neoplasms↗

PubMed1990

[The effect of hormones on tumor growth].

It is well documented that estrogen influences the growth of mammary carcinoma. Estrogen-induced response of target tissue includes protein-biosynthesis as well as stimulation of cell proliferation. Estrogen stimulates tumor cell proliferation in vitro in a dose-related manner by shortening the cell cycle time primarily at the G1 duration and by increasing the number of dividing cells per cycle. The mechanisms of estrogen action on target cell proliferation are not understood well and because of controversial experimental results the role of functional estrogen receptors in estrogen-induced proliferation is not yet clear. In this work, we studied the effect of estrogen on the growth of cells derived from primary tumors (N = 4) and malignant pleural effusions (N = 6) from patients with histopathologically verified breast cancer. We correlated steroid receptor content of malignant tissue used with results obtained for estrogen-induced cell proliferation. It was shown that there was a positive correlation between steroid receptor content and effect of estrogen on cell proliferation in most of the cases studied (7/10). Our study also confirms the possibility of positive and negative influences of estrogen on modulation of tumor cell growth.

Breast Neoplasms↗

PubMed1989

[Surgical treatment of uncontrolled hemorrhage in the retroperitoneum of the minor pelvis].

The purpose of our work is to point out some wellknown facts about the bleeding from presacral vessels, because of This bleeding may be very profuse and dangerous. It occurs as intraoperative complication in combined abdominoperineal resection of the rectum, as well as the avulse injuries of the retroperitoneal part of the rectum, which are usually combined with fractures of the sacral, coccigeal or other bones of the pelvis. We want to show here, that it is not recommended to spend a lot of time in trials to make haemostasis with the usual methods, it is better to pack the whole area with gauze, as the only way to control such bleedings.

Adolescent↗

PubMed1989

[High doses of Streptase in the treatment of deep venous thrombosis of the lower extremities].

We apply the high dosed Steptase in last 10 months, and we find that there are the following advantages compared with the conventional application of Streptase: in 81,20% of cases we had had good results; it reduces the frequency of the complications-bleeding occurred in only 6.20% of the treated patients; it simplifies the application and reduces the lasting of the hospitalisation; In 12 of our 13 patients the treatment was one or two days; in only one case the treatment was repeated the third day.

Female↗

PubMed1989