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Biomedical subjects

D Nag

Publications and source records attributed to D Nag.

82 records · Page 5Linked to original sources
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Clinical and biochemical changes in chronically exposed organophosphate workers.

Health effects of occupational organophosphate exposure were investigated by subjecting 22 workers chronically exposed to an organophosphate pesticide, fenthion (O,O-dimethyl-O-(4-methylmercapto-3-methylphenyl)-phosphorothioate) to clinical evaluation, estimation of serum cholinesterase, serum alkaline phosphatase (SAP), serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT). The mean age of the workers was 31 years and the mean duration of fenthion exposure 8.2 years. Headache (59%), giddiness (50%), ocular symptoms (27%) and paresthesia (18%) were the commonest symptoms. Serum acetylcholinesterase and butyrylcholinesterase levels were significantly lower than in controls. After withdrawing the workers from organophosphate exposure for 3 weeks, the follow-up study revealed absence of transient symptoms. There was no change in their neurological status, and serum acetylcholinesterase and butyrylcholinesterase levels were raised significantly, whereas the other serum enzymes showed no significant change. For monitoring of occupational organophosphate exposure, the importance of both clinical and biochemical parameters is emphasised.

Adult↗
PubMedDate not supplied

Endemic fluorosis presenting as cervical cord compression.

Neurological involvement in fluorosis occurs in the advanced stage of the disease and is due to compression of the spinal cord and/or nerve roots. There are only a few reports on the role of surgical management of these cases in the medical literature. Five cases of fluorosis from the endemic areas of Uttar Pradesh, India, had associated cervical cord compression. Their mean age was 43 yr (range 35-50), and all cases were manual laborers. Three patients with blocked cervical subarachnoid space on myelography underwent laminectomy using local anesthesia. All three cases improved significantly after surgery. The usefulness of laminectomy in selected cases of cervical cord compression due to fluorosis is suggested.

Adult↗
PubMedDate not supplied

F-response studies in neonates, infants and children.

F-response has been found to be useful in the evaluation of peripheral nerve conduction in adults and may be especially useful in paediatric nerve conduction studies. In newborns, the nerve conduction velocity is very slow compared to adults because of immaturity of myelination. To assess the effect of age on F-response in 20 neonates, (1 to 28 days), infants (1 mo- 1 y) and children (2-12 y), motor nerve conduction velocity of median, peroneal; sensory conduction velocity of median and F-response from abductor pollicis brevis (APB) by stimulation of median nerve at the wrist were evaluated. The nerve conduction velocity in the neonates was nearly half of that in children and was significantly related to age. F-minimal latency (F-min) showed biphasic distribution; in neonates it was 17 ms, in infants 15 ms and in children 16 ms. The amplitude of F-response was higher compared to infants and children (P less than 0.001). H-reflex in ABP was elicited in all neonates and 55% of infants, its mean latency was 17.9 ms and 15.7 ms respectively. Long latency and high amplitude of F-response and presence of H-reflex in ABP in neonates and infants are due to the immaturity of the nervous system and should be kept in mind while interpreting F-responses in newborns.

Age Factors↗