Biomedical subjects

D N Wright

Publications and source records attributed to D N Wright.

39 records · Page 3Linked to original sources

PubMedDate not supplied

Prophylaxis of predisposed otitis externa.

Evaluation, in the guinea pig ear, of fourteen water repellent or therapeutic compounds has resulted in the recommended use of 360 Medical Fluid as a prophylactic agent for those persons with a high risk of otitis externa. This compound was found to adhere well, be easy to apply and was nonirritating. Use of this material prevented adverse bacterial growth in ear canals exposed to water for up to seven days. The significance of maintaining the normal Gram positive bacterial flora in the external ear canal and the role of cerumen in maintaining a healthy meatal surface is discussed. A system for monitoring the health of the ear canal through measurement of the Gram positive/Gram negative bacterial ratio is suggested.

1-Propanol↗

PubMedDate not supplied

Local reactions to stinging insects (Hymenoptera).

Hymenoptera stings cause cutaneous nonallergic local reactions of limited size and duration in most individuals. Some subjects experience an allergic local reaction (large local reaction) to a sting that is greater than 10 cm in diameter and may last for up to 5 days. The nonallergic local reaction is a toxic response to venom constituents, while the large local reaction appears to be caused by an allergic reaction to venom proteins. The IgE-mediated late-phase reaction is probably responsible for most of these reactions; however, a cell-mediated mechanism, or a combination of the two, is possible. A diagnostic workup is not recommended for local reactions. However, skin testing with Hymenoptera venoms (bee, wasp, hornet, and yellowjacket) identifies most subjects with sting-induced large local reactions. Therapy of the local reactions is symptomatic. An oral glucocorticosteroid, H1 antagonist and possibly a H2 antagonist are indicated for treatment of large local reactions. Venom immunotherapy is effective in preventing recurrences of large local reactions in children but is not usually recommended for either adults or children.

Adult↗

PubMedDate not supplied

Current treatment of allergic rhinitis and sinusitis.

Sinusitis is an infectious, inflammatory disease. Aggressive, multifaceted treatment is often required for control, with emphasis on anti-inflammatory therapy. Medical and surgical treatment is similar in children and adults, but more aggressive therapy, particularly surgery, is more controversial in the former.

Adolescent↗