Epidermal melanocytes in eruptive xanthomas. An ultrastructural study.
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Biomedical subjects
Publications and source records attributed to D N Silvers.
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The intracellular content of K(+) in thalassemia minor red blood cells is markedly reduced after incubation in autologous serum for 24 hr at 37 degrees C. There is no compensatory increase in intracellular Na(+) concentration of the cell thus reduced. This change is due to an acquired increase in selective permeability of the membrane to K(+). This phenomenon follows the depletion of energy sources in the thalassemia minor cells but does not follow comparable depletion in normal cells. The loss of osmotically active intracellular contents probably accounts for the increased resistance of incubated thalassemia minor red blood cells to osmotic lysis.
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We report four patients with antibodies to human immunodeficiency virus and/or acquired immunodeficiency syndrome who were noted to have unique vascular lesions that clinically resembled Kaposi's sarcoma or pyogenic granulomas. The lesions were asymptomatic erythematous-violaceous papules and nodules. They erupted over several weeks, without predilection for a specific cutaneous site. Most lesions resolved spontaneously. Histologically these lesions revealed a proliferation of vascular spaces lined by plump, cuboidal endothelial cells embedded in an edematous stroma with an inflammatory infiltrate. It is unclear if these lesions represent Kaposi's sarcoma or pyogenic granulomas or if they are distinct neoplasms associated with human immunodeficiency virus.