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Biomedical subjects

D N Hamilton

Publications and source records attributed to D N Hamilton.

At least 55 records · Page 3Linked to original sources
PubMed1978

A new predictive factor for the outcome of renal transplantation.

The cell mediated immunity (CMI) of a group of patients on regular haemodialysis was measured using a modified dinitrochlorobenzene (DNCB) skin test. The strength of the reaction was graded from 0 to 15 on an objective scale which we called the DNCB index. This index was much reduced in the dialysis patients in comparison with a group of healthy controls. Thirty-six dialysis patients were subsequently transplanted and graft survival was assessed at six months. A significantly higher graft failure rate was observed in those with a strong skin reaction than in those with a weak or absent response (P less than 0.01). While the mean DNCB is much lower than normal in dialysis patients, there is a wide variation within this group. We have found that the DNCB index correlates well with renal allograft survival suggesting that this skin test has value in the prediction of transplant outcome.

Adolescent↗
PubMed1976

In-vitro monitoring of cell-mediated immunity to dinitrochlorobenzene.

A dinitrochlorobenzene (D.N.C.B.)/red-blood-cell conjugate inhibited migration of leucocytes which came from D.N.C.B. sensitised patients. This effect provided the basis for a rapid, sensitive, and quantitative in-vitro measure of D.N.C.B. sensitivity. Frequent serial measurement of cell-mediated immunity was possible with the test, provided D.N.C.B. sensitivity was maintained by occasional skin patch tests.

Cell Migration Inhibition↗
PubMed1976

Bilateral nephrectomy prior to renal transplantation.

Bilateral nephrectomy was performed in 53 patients on regular haemodialysis. The indications were pyelonephritis in 30, polycystic kidneys in 6, glomerulnephritis in 7, uncontrollable hypertension in 9 and horseshoe kidney in 1. In 87 per cent of cases the operation was carried out as a separate procedure prior to transplantation. The mortality was 9 per cent and the postoperative complications included hypotension, clotting of arteriovenous shunts, pneumonia and subphrenic abscess. As a result of our experience we have revised our indications for bilateral nephrectomy which now are pyelonephritis only when associated with persistent bacteriuria or ureteric reflux, polycystic kidneys and uncontrollable hypertension.

Adolescent↗
PubMed1976

The Sparks Mandril for vessel access in haemodialysis.

The Sparks Mandril, placed as a forearm loop, provides excellent access for haemodialysis. The long-term patency rate however, is less than for other access devices and hence the mandril's place at present is in patients with access problems.

Arteriovenous Shunt, Surgical↗
PubMed1975

Ultrasound in the diagnosis of fluid collections following renal transplantation.

Ultrasound examinations of the pelvis and kidney have been carried out following 68 renal transplants. In 16 patients moderate sized or large perirenal or pelvic fluid collections were demonstrated. The composition of the fluid was lymph in seven cases, pus in four, blood in three and urine in two. Ten of these 16 patients had clinical features compatible with a pelvic fulid collection while six had no such localising features. We have found ultrasound to be extremely valuable in the diagnosis and precise localisation of pelvic fulid collections following transplantation, often at a stage before pressure effects and symptoms have appeared. It also provides a rapid and reliable means of excluding a pelvic or perirenal abscess in the pyrexial patient.

Abscess↗