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Biomedical subjects

D N Baron

Publications and source records attributed to D N Baron.

At least 55 records · Page 3Linked to original sources
PubMed1979

Medical careers in pathology, 1977.

A survey has been made, mainly covering the second half of 1977, of career grade posts and senior training posts in pathology in the United Kingdom. The survey included all disciplines of pathology and all types of employment--National Health Service, medical school, and many others. The survey also examined the number of applicants for advertised posts and the number of posts left vacant. There were variations between disciplines and between regions; microbiology and Northern Ireland had most failures in filling posts. Overall about 3% of career grade posts, and 15% of training grade posts, were left unfilled.

Career Choice↗
PubMed1977

Leucocyte intracellular pH in patients with the metabolic acidosis of renal failure.

1. Human leucocytes were isolated from venous blood and resuspended in the subjects plasma. 2. Intracellular pH measurements were made in vitro by the dimethyloxazolidinedione technique in 13 healthy subjects and in 11 subjects with renal failure and metabolic acidosis. 3. The intracellular pH of the healthy subjects was found to be 7-07 (SD 0-04), significantly lower than that of the patients, which was 7-11 (SD 0-03). For all estimations plasma PCO2 was maintained at approximately 5-5 kPa. The methodological and possible metabolic reasons for this difference in intracellular pH are discussed.

Acidosis↗
PubMed1976

The intracellular pH of human leucocytes in response to acid-base changes in vitro.

1. Viable human leucocytes were isolated from venous blood and suspended in artificial media. Intracellular pH measurements were made by the dimethyloxazolidinedione technique in conditions simulating "respiratory" or "metabolic" acid-base disturbances. 2. Normal intracellular pH was 7-11 +/- 0-02 (mean +/- 2 SD) at an extracellular PCO2 of 5-8 kPa and a bicarbonate concentration of 25 mmol/l. 3. "Respiratory" and "metabolic" acidosis caused little change in pHi although increases in PCO2 led to relatively greater falls in pHi than did reduction in external bicarbonate concentration. 4. "Respiratory" and "metabolic" alkalosis caused similar and relatively greater increases in the pHi when compared with the response to an external acidosis.

Acid-Base Equilibrium↗
PubMed1975

Casual blood-ethanol estimations in patients with chronic liver disease.

Patients attending a clinic for diseases of the liver were tested for blood-ethanol by a gas chromatographic technique sensitive to about 5 mg/dl (1 mmol/1). Of 172 patients (51 men, 121 women) 36% gave a history of heavy drinking (greater than 80 g ethanol/day; equivalent to 8 fl oz of whisky or 1 litre of wine) and 13% had ethanol in the bloodstream at values of 8-400 mg/dl. 42 patients (24%) had the liver-biopsy changes of alcoholic liver disease, and 17 of these had ethanol in the blood at one time or another. Nearly half (22/49) of all patients admitting heavy drinking also had detectable blood-ethanol. In all cases but 1 where blood-ethanol was found, a drinking history was admitted on first attendance, and alcoholic liver disease was nearly always found on subsequent biopsy. Blood-ethanol and admission of drinking were most constantly found in association with alcoholic steatosis and hepatitis. Both features were less commonly present in cases of alcoholic cirrhosis. Only 1 patient of 22 with "cryptogenic" cirrhosis on biopsy was found to have both ethanol in the blood and an alcoholic history, although 5 had an alcoholic history alone. The value of serial blood-ethanol estimations in the treatment of alcoholics and the detection of relapses is demonstrated. The findings confirm the relatively low frequency of alcoholism as a contributor to cirrhosis in the United Kingdom. Alcohol does not seem a major cause of cryptogenic cirrhosis. Casual blood-ethanol estimation is a useful and objective adjunct to techniques of investigating diseases of the liver.

Alcohol Drinking↗
PubMed1975

Training and organization for pathology in Britain. The role of chemical pathologists.

In Britain, the term "clinical pathology" indicates the discipline of pathology applied to patients, whereas "chemical pathology" refers to pathology in its chemical and biochemical aspects, both as a basic science and for patient care. The initial training of a chemical pathologist is usually in general pathology, in metabolic medicine, or in research. This training continues solely in chemical pathology, and the specialist qualification, namely Membership of the Royal College of Pathologists, is taken at about 32 years of age. Training is similar in the other disciplines of pathology, and a pathologist usually achieves a senior permanent appointment by the age of 34 years. By national policy, pathology laboratories, each with departments of chemical pathology, hematology, histopathology, and microbiology, are centered in about 250 District General Hospitals. The chemical pathology section ideally includes both a medical consultant and an equivalent non-medical scientist. These ideals are unlikely to be reached because of pathologists usually include laboratory supervision, clinical liaison, teaching, and research. Many chemical pathologists also have specific clinical consultant activities, such as overseeing a Metabolic Unit.

Chemistry, Clinical↗
PubMed1975

SI units.

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Chemistry, Clinical↗